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Showing 1 to 4 of 4 for “"Extended cooks kinetic method"”.
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The variation of the gas phase acidity of a cysteine residue in oligopeptides
… Δ<sub>acid</sub>S) were determined by using the extended Cooks kinetic method. A triple-quadruple mass spectrometer interfaced with an electrospray ionization source was employed for the study. The gas phase acidities of the N-terminal cysteine peptides (CysAla<sub>1,2</sub>NH<sub>2</sub> and …
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Determination of the proton affinities of gas phase peptides by mass spectrometry and computational chemistry
… peptides using mass spectrometry by applying the extended Cooks' kinetic method. Favorable conformations and theoretical proton affinities were probed using computational chemistry. The proton affinities determined for Na-acetyl-(L)-lysine, Ac-AK, Ac-KA, and Ac-KAA are 236.8 ± 1.9 kcal …
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Synthesis and mass spectrometry studies of oligopeptides
… and AA<sup>D</sup>AC, were measured by the extended Cooks kinetic method. Gas-phase acidities of CAA<sup>D</sup>A and AA<sup>D</sup>AC were measured to be about 318 kcal/mol and 322 kcal/mol, respectively. These values are different from the gas-phase acidities of the all L-amino acid …
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Thermochemical differences in lysine and lysine-homolog containing oligopeptides: Determination of basicity and gas-phase structure through mass spectrometry, infrared spectroscopy, and computational chemistry
<p>The data presented in this thesis is a comprehensive study on the nature of peptide structure and how subtle and systematic changes in sequence and sidechain affect the basicity, ion stability, and conformation of a peptide. The peptides characterized were acetylated polyalanine di-, tri-, and …