Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Expression microarray"”.
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Probabilistic Finite Mixture Clustering of Genetic Expression Microarray Data
Exploratory cluster analysis of large data sets often implements k-means or hierarchical methods. These routines typically exhibit limitations which reduces the reliability of the results. Both assign observations to the one component for which its Euclidean distance from the center is smallest. …
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Gene expression microarray analysis of small, purified cell subsets
Gene expression microarray technology is potentially capable of examining all of the cellular processes at the mRNA level at a given moment. One major challenge in its applicability is that most biological samples are cell mixtures and the cell type of interest is often a minor cell subset. Using …
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New approaches to open problems in gene expression microarray data
… Among the most important innovations is the microarray tecnology. It allows to quantify the expression for thousands of genes simultaneously by measurin the hybridization from a tissue of interest to probes on a small glass or plastic slide. The characteristics of these data include a fair …
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Detecting Changes in Alternative mRNA Processing From Microarray Expression Data
… a billion dollars' worth of conventional gene expression microarray data archived over the past 20 years using a program we created called SplicerAV. Application of SplicerAV to publicly available microarray data has granted new insights into previously existing studies of oncogene …
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Molecular Pathogenesis of MALT lymphoma
… cell lymphomas were analysed by Affymetrix gene expression microarray platform. Unsupervised clustering showed that cases of MALT lymphoma were clustered as a single branch. However, within the MALT lymphoma group, translocation-positive cases were intermingled with translocation-negative cases. …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… uterus from mouse to human. Using miRNA and gene expression microarray analyses of uterine tissues, we identified a conserved family of miRNAs, the miR-200 family, that is highly induced at term in both mice and humans, as well as two coordinately downregulated targets, zinc finger E-box binding …
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A Pairwise Feature Selection Method For Gene Data Using Information Gain
… classification has limitations when using gene expression microarray data. For example, the robustness of top scoring pairs does not extend to some datasets involving small data size and the gene set with best discrimination power may not be involve a combination of genes. Hence, it is necessary …
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Lung disease diagnosis from gene expression profiles
… a broad range of lung diseases. We used gene expression microarray data from five different lung diseases—lung adenocarcinoma, lung squamous cell carcinoma, large cell lung carcinoma, chronic obstructive pulmonary disease, and asthma—as well as a non-diseased phenotype, to train a …
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Extending the Graphical Representation of four KEGG Pathways for a Better Understanding of Prostate Cancer Using Machine Learning of Graphical models
… discussed. The work is based on Affymetrix gene expression microarray profiles and penalised Gaussian linear models. Penalisation in linear models includes choosing the most important parents and estimating the associated coefficients simultaneously using L1-regression. The sparse dataset that is …
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Evidence for enhanced oxidative stress in smokers with severe asthma
… by analysing urinary 8-iso-PGF2a and the mRNA expression of the main pro-oxidant (NOX2; NOSs) and anti-oxidant (SODs; CAT; GPX1) enzymes in the airways, in relation to clinical outcomes. Methods Urine and induced sputum (IS) were obtained from severe asthma patients. A bronchoscopy to obtain …
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Evaluation and Optimization of the Translational Potential of Array-Based Molecular Diagnostics
… and prognostic platforms developed using expression microarray technology is evident. However, the majority of array-based diagnostics have yet to make their way into the clinical laboratory. Current approaches tend to focus on development of multi-gene classifiers of disease subtypes, but …
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Galectin-3 Enhances The Malignant Melanoma Phenotype By Regulating Autotaxin
… patient specimens and cell lines, the over expression of galectin-3 is associated with disease progression and metastatic potential. Herein, we have sought out to determine whether galectin-3 affects the malignant melanoma phenotype by regulating downstream target genes. To that end, …
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Investigations into the effects of berry flavonoids on nutrient transport processes in Caco-2 enterocytes
… elucidated. To address this we carried out gene expression microarray analysis on intestinal Caco-2 cells treated with a flavonoid-rich berry extract (0.125 % w/v for 16 h). This microarray analysis identified alterations in numerous specific nutrient pathways, three of which were selected for …
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Microarray-based differential gene expression of listeria monocytogenes cultures grown as biofilms and planktonic cells
… biofilm cells. A complete genome global gene expression microarray of a L. monocytogenes culture grown as biofilm and planktonic cells provides critical information to better understand the pathogenicity (causes many deaths) of L. monocytogenes, possible drug targets, and advancements in …
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Zebrafish cardiovascular cDNA microarrays : expression profiling and gene discovery in embryos exposed to 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin
… in processes of toxicity. We constructed microarrays using cDNA libraries derived from zebrafish embryonic and adult heart tissue. Embryonic heart arrays were used for protocol development. The resulting workflow was employed in the production of adult heart microarrays containing ~2800 …
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The Analysis of the MCF7 Cancer Model System and the Effects of 5-AZA-2'-Deoxycytidine Treatment on the Chromantin State Using a Novel Microarray-Based Technology for High Resolution Global Chromatin State Measurement
A microarray method to measure the global chromatin state of the human genome was developed in order to provide a novel view of gene regulation. The 'chromatin array' employs traditional methods of chromatin isolation, microarray technology, and advanced data analysis, and was applied to a cancer …
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Identification of Host and Parasite Factors Mediating the Pathogenesis of Severe and Cerebral Malaria
… disease due to Plasmodium falciparum. In vivo, expression microarray analysis showed that, in malaria target organs, differential responses were related to immune response – primarily interferon and complement pathways – and apoptosis. Histopathological examination of the brain confirmed an …
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Nfat1 Contributes to Melanoma Tumor Growth and Metastasis By Regulating Il-8 and Mmp-3
… in melanoma progression we stably silenced NFAT1 expression in the highly metastatic cell line, A375SM, and subjected the cells to gene expression microarray analysis. We identified and validated two downstream targets of NFAT1, i.e; IL-8 and MMP-3 to be downregulated following silencing NFAT1. …
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Role of the IKKβ/NF-κB pathway in alcoholism
… Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, transcriptome meta-analysis in rodents, and drinking models in mice support the role of neuroimmune signaling in alcohol abuse disorder. Nuclear factor kappa-B (NF-κB) is a …
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Unraveling the Structure and Assessing the Quality of Protein Interaction Networks with Power Graph Analysis
… that compressibility is correlated with co-expression, co-localization and shared function, v) showing that complete and accurate networks of complex systems in other domains exhibit similar levels of compressibility than current high quality interactomes. Third, we apply power graph …
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