Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"Exposed Uninfected"”.
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The Gut Mucosal Microbiome of HIV- exposed Uninfected Infants in Africa
… Due to the success of the PMTCT program, HIVexposed-uninfected (HEU) infants represent a growing population in South Africa. However, these infants have been found to have increased morbidity and mortality rates compared to their HIV Unexposed Uninfected (HUU) peers, as well as altered immune …
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Exploring the gut microbiome: metaproteome analysis of HIV-exposed uninfected infants
… a new generation of HIV infected and unexposed infants (HEU) with unknown health implications. These infants have been observed to be more vulnerable to disease and have weaker immune responses. The gut microbiome plays a pivotal role in human health by aiding in metabolism, nutrient …
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Cellular immune ontogeny and birth transcriptome in HIV-exposed uninfected infants
… number of children born to these mothers are exposed to HIV and antiretrovirals (ARVs) in utero yet remain uninfected. These individuals, known as children who are HIV-exposed and uninfected (cHEU), succumb to higher rates of disease morbidity compared to children who are HIV-unexposed (cHU) …
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Early childhood diarrhea and growth among HIV-exposed, uninfected infants in Kenya
… number of HIV-infected women giving birth to uninfected children. These HIV-exposed, uninfected (HEU) children, are an understudied and uniquely vulnerable population who experience higher rates of death and disability than their unexposed counterparts. These HEU children may be an important …
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Correlates of tuberculosis and non-tuberculosis morbidity and immunity in sub-Saharan African HIV-exposed, uninfected infants
… is a growing population of infants who are HIV-exposed but uninfected (iHEU), particularly in sub-Saharan Africa. These infants experience an increased risk of morbidity compared to infants who are HIV-unexposed and uninfected (iHUU), predominantly due to infectious diseases. Although the …
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Protection from HCV infection – Identification of mechanisms of resistance to HCV infection in exposed uninfected injection drug users.
… of people who inject drugs (PWIDs) remain uninfected despite HCV exposure from a long history of sharing needles and other paraphernalia. These cases are termed exposed but uninfected (EU) and test negative for both HCV antibodies and RNA and exhibit a phenotype of resistance to HCV …
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A description of HIV-exposed uninfected infants in the IeDEA Southern Africa Cohort and an examination of growth outcomes
… infants born to HIV-infected mothers who remain uninfected. The characteristics of these HIV-exposed uninfected infants are not well known, including growth and other health outcomes. The International Epidemiologic Databases to Evaluate AIDS Southern Africa (IeDEA-SA) research strategy 2011-2016 …
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CD4 and CD8 T-cell responses to acellular pertussis and rotavirus vaccination in breast-fed HIV exposed, uninfected infants
… As a result there is an increasing number of HIV exposed, uninfected infants (HEU). HEU infants have a higher rate of infectious disease related mortality and morbidity compared to unexposed infants, the underling causes of these differences are still not understood. In this dissertation, …
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The association of maternal HIV status during pregnancy on longitudinal neuro-immune regulation, and neurodevelopment in HIV-exposed uninfected children
… therapy (ART), more children are now being born uninfected with HIV while still being exposed to the virus in utero. Exposure to HIV in utero may still negatively affect the developing brain of these children. However, the biological mechanisms involved in the neurodevelopmental outcomes in …
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Postnatal Clubs: Implementation Of A Differentiated And Integrated Model Of Care For Mothers Living With Hiv And Their HIV-Exposed Uninfected Babies
Background Despite the reduction in the HIV mother-to-child transmission (MTCT) rate in South Africa, there are ongoing concerns in the breastfeeding period, linked to poor retention in care. To improve this retention, Post Natal Clubs (PNC) were created as an integrated, differentiated model of …
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A comparative analysis of the medicine use and exposures in infants who are HIV exposed uninfected and HIV unexposed uninfected in the first year in Cape Town, South Africa
… monitoring of medications in infants who are HIV-exposed uninfected (HEU), a growing population, remains poorly studied. This study aimed to describe and compare medication consumption patterns, including immunization coverage, between infants who are HEU and HIV-unexposed uninfected (HUU) during …
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Evaluation Of An Infant Feeding Support Strategy Among Hiv-Exposed Infants In Urban Haiti
… essential to improve health outcomes among HIV-exposed children. However, there are few evidence-based models for effective integration of nutrition support within clinical Prevention-of-Mother-to-Child-Transmission (PMTCT) services. To address this gap, we aimed: 1) to describe the problem of …
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The effect of HIV-exposure on immune responses to expanded programme on immunization vaccines and antigens
… immunity via vaccines a challenge. HIV-exposed infants are HIV uninfected and born to HIV-infected mothers and have increased morbidity and mortality of unknown aetiology. We hypothesise that T cells of HIV-exposed uninfected (HEU) infants have impaired proliferative ability and cytokine …
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DTI-based tractographic analysis of white matter alterations in HIV infected children
… children who intiatied early cART compared to uninfected controls. To explore possible relationships between these alterations, we used tractography to identify HIV-related abnormalities within structural connections located in functional resting state networks. Within HIV+ children (n=61), we …
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An investigation into the role of HIV exposure status in infectious disease mortality in children in Western Cape
… Findings: 38.71% (36/93) of cases were HIV exposed versus 22.58% (21/93) of controls (p=0.017). 32.36% (30/93) of cases were HIV exposed uninfected (HEU) versus 18.28% (17/93) of controls (p=0.06). Being HEU was a risk factor for mortality after adjusting for age, sex, feeding practice, and …
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Comparison of Magnetic Resonance Spectroscopy (MRS) data in children with and without HIV at 11-12 years
… Antiretroviral Therapy (CHER) trial, and HIV-exposed-uninfected (HEU) children, to HIV-unexposed (HU) children. Pearson's correlation analysis, factor analysis and logistic regression were then used to study alterations in metabolic patterns between HIV+ and HIV-uninfected (HIV-) children. …
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Molecular Mechanisms of Protection from Hepatitis C Infection
… remain negative for HCV infection are termed exposed uninfected (EU). Understanding the factors that prevent HCV infection in this cohort could give valuable insight into the mechanisms of natural resistance to HCV infection. The EU cohort was previously shown to have characteristics …
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Growth and determinants at two years of age in a South African birth cohort
… data from 897 children (51% male; 22% HIV-exposed, uninfected) were included. 69 (8%) were underweight, 20 (2%) were wasted and stunting occurred in 167 (19%) children; 116 children were overweight (13%), and 42 were (5%) obese. Overall, 351 (39%) had some form of growth impairment. Higher …
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The impact of maternal HIV infection on uninfected neonate brain structure
… resulting in an increasing population of HIV-exposed uninfected (HEU) children. However, the long-term effects of HIV and antiretroviral therapy (ART) exposure on the developing brain is not well understood. While HEU children perform better than their counterparts living with HIV, they …
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The influence of HIV and ART exposure on neonate brain volumes
… achievement is an increasing population of HIV-exposed-uninfected (HEU) infants and children. Despite improved outcomes compared to their peers living with HIV, HEU infants and children are at risk of neurodevelopmental delays in relation to HIV–unexposed–uninfected (HUU) children. As a result, …
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