Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Exportin-1"”.
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Understanding the adhesome network in primary and metastatic cutaneous squamous cell carcinoma
… From the network analysis, we found that exportin-1, a mediator of protein export from the nucleus to the cytoplasm, is an important hub during cancer progression. Interestingly, one of the interactors of exportin-1 is the actin-regulator Mena. We found that Mena has a nuclear function in …
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Expression Profiling of Transgenic Arabidopsis Over- and Underexpressing SR45, a Plant-Specific Serine /Arginine -Rich Factor
… of important transport factors (nucleoporin 155, exportin 1) as well as several stress-related transcripts that may represent secondary downstream targets. As a result of these secondary effects, it is likely that SR45-silenced plants are more susceptible to stress.
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Nuclear accumulation of G-actin in cellular senescence: Reduced expressions of exportin 6 and Ran small G protein
… actin is exclusively kept in the cytoplasm by exportin 1 (CRM1)-driven nuclear export. However, CRM1 has been reported to be not directly involved in actin export from vertebrate or Drosophila nuclei. On the other hand, exportin 6 (exp6) has been found as a novel family member from higher …
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Nuclear export signals (NESs) in Arabidopsis thaliana : development and experimental validation of a prediction tool
… proteins from the nucleus involves the receptor Exportin 1 and the presence of a nuclear export signal (NES) in the cargo protein. Given the big amount of sequence data available nowadays the possibility to use a computational tool to predict the proteins potentially containing an NES would help …
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Structural and functional characterization of proteins involved in the biogenesis of spliceosomal U snRNPs
… transportierenden Protein Snurportin 1, dessen Exportin (Exportin 1) und dem kleinen molekularen Schalter RanGTP besteht. Darüberhinaus sollte der Bindungsmodus der Poly(A)-spezifischen Ribonuklease an das 5 -mRNA-cap strukturell untersucht und beschrieben werden. Im Folgenden werden die …
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Role of Sub-Cellular Localization and Cellular Factors In Regulation of HIV-1 Tat Protein Stability
… Tat stability. siRNA mediated knock down of exportin-1 (Xpo1), which is the most common nuclear export pathway in cells, resulted in suppression of Tat degradation. Similarly, use of Leptomycin B (LMB), an inhibitor of Xpo1 mediated nuclear export rescued Tat from degradation. The data …
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LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS OF POST-TRANSLATIONAL MODIFICATIONS TO HMGB1 AND ITS REGULATED SECRETION IN LUNG CANCER
… was dose-dependent and was regulated by nuclear exportin 1 (XPO1) also known as chromosomal maintenance 1 (CRM1) rather than acetylation or oxidation. Malignant mesothelioma (MM) cell lines were found to constitutively secrete unacetylated HMGB1, and the cysteine oxidation profiles in HMGB1 from …
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Structural and functional analysis of exportin-cargo recognition
… welche Import-Rezeptoren ( Importine ) und Exportine umfasst. Importin 13 und Msn5p sind Ausnahmen, da sie sowohl Import als auch Export vermitteln. In dieser Arbeit haben wir gezeigt, dass Exportin 4, zusätzlich zu seiner etablierten Rolle als Export-Rezeptor, Transkriptionsfaktoren der …
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Nuclear import of histone fold motif containing heterodimers by importin 13
… detektiert. Da im Zuge der Untersuchungen Exportin 1 als potentieller Exportfaktor für p12/CHRAC-17 ausgeschlossen werden konnte, sind demzufolge andere nukleäre Exportrezeptoren für den zellzyklusabhängigen Export des histone fold Dimers verantwortlich.
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Analysis of SMAUG1 protein motifs and interacting partners - linking regulation of phase separation to human disease
… that promotes rapid export to the cytoplasm via exportin-1. Crucially, investigation of SMAUG1’s RNA targets in and out of condensates revealed a potential nuclear role for SMAUG1 in splicing through binding of intronic and exonic transcript regions. These findings expand SMAUG1’s functionality …
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Investigating the role of nuclear transport proteins secreted by cancer cells
… Kpnb1 revealed that Kpnb1 is bound to Exportin 1 (CRM1) in the secretome of cancerous and non-cancerous cells. It also showed that Kpnb1 secreted from CaSki, WHCO5, Kyse30 and hTERT RPE-1 is bound to a Kpnb1 adaptor protein, Karyopherin subunit alpha 2 (Kpna2). IP-MS of Kpnb1's binding …
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The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal
The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of various cells irrespective of ligand stimulation, but neither the specific amino acid motif nor the responsible nuclear localization signal (NLS) has not been previously reported. Here, we report that two …