Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 168 for “"Experimental models"”.
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Experimental Models of Brain Hemorrhage Using Clostridial Collagenase
… goal of this study is to establish novel animal models to buildup foundations for translational research of intracerebral hemorrhage. We, for the first time, established four animal models, including cerebellum hemorrhage, pontine hemorrhage, neonatal matrix hemorrhage and maternal postpartum …
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Experimental Models of Mycobacterial Replication and Killing in Macrophages
… mice and Fas receptor-defective mice were experimentally infected with mycobacteria. The loss of either intact Fas pathway or perforin gene did not render mice more susceptible to mycobacterial infection, confirming the findings in vitro. Further studies in vitro of the killing of …
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Benchmark Studies For Structural Health Monitoring Using Analytical And Experimental Models
… real structures can be achieved by integrating experimental, analytical and information technologies on real life, operating structures. Real-life investigations must be backed up by laboratory benchmark studies. In addition, laboratory benchmark studies are critical for validating theory, …
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Experimental models with specific approaches to augment human fetal liver cell engraftment
Experimental models with specific approaches to augment human fetal liver cell engraftment Pradeep Patil Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg Background: Liver disease is a common cause of morbidity and mortality worldwide. …
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
A major yet unsolved quest in treating traumatic brain injury (TBI) is the understanding of the secondary cellular injury that contributes to cell death. Whether zinc ions are toxic or protective in TBI is controversial. As an essential human micronutrient, zinc is needed for the structure and …
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Mechanisms behind the lipid-lowering effects of ACTH - Studies in different experimental models
… medications. When exploring possible animal models for more detailed mechanistic studies, we found that species differences in lipid transport made the rat an unsuitable model for further investigations. The effects of ACTH on diet-induced hyperlipidemia in the rabbit, however, were similar …
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Nutritional factors influencing tissue omega-3 metabolism and endocannabinoids levels in experimental models and humans
… from its precursor alpha linolenic (ALA), in experimental models and humans. We found that different dietary ALA/CLA ratios affected n-3 PUFA and EC profile with a graded decrease of ALA and EPA and corresponding increase of DHA, while the EC arachidonoylethanolamine (AEA) decreased parallel …
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DECODING CELLULAR AND TEMPORAL VARIABILITY IN HUMAN CORTICAL DEVELOPMENT. INTEGRATING SINGLE-CELL TRANSCRIPTOMICS ACROSS DEVELOPMENTAL STAGES AND EXPERIMENTAL MODELS.
… of gene function and iPSC-derived experimental models within human neurodevelopment, providing new insights into the dynamics of cellular processes and the basis of brain disorders. We use NeuRoDev to investigate cell physiological processes, neuronal and glial cell maturation, and …
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Effects of carnosine in experimental models of neuroinflammation: focus on human microglia [Effetti della carnosina in modelli sperimentali di neuroinfiammazione: focus sulla microglia umana]
La microglia, le cellule immunitarie del cervello, sono essenziali per lo sviluppo del cervello, la plasticità sinaptica e la neurogenesi, essendo responsabili del mantenimento dell'equilibrio eliminando proteine mal ripiegate e cellule morte. La perdita dello stato omeostatico della microglia è …
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Effect of build angle and print layer thickness on clinical accuracy of 3D-Printed orthodontic models
… build angle impact the accuracy of orthodontic models produced using a digital light processing (DLP) 3D printer. Orthodontic models were generated from a digital master model derived from an ideal maxillary typodont scan. The study tested six different configurations: 100 µm-0°, 100 µm-70°, 100 …
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Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models
… virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and premalignant abnormalities include disturbances in intracellular signaling and ongoing injury with oxidative stress, inflammation, and lipotoxicity. The major signal transduction pathways …
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Ενδομυελική εφαρμογή δύο ήλων Ender's εις κατάγματα κνήμης
… IN 57 PATIENTS WITH 59 FRACTURES. WE CREATED TEN EXPERIMENTAL MODELS AND TESTED THE METHOD IN NAT.TECHN. UNIVERSITY, ATHENS. THE AVERAGE HEALING TIME WAS 3,13 MONTHS WITH EXCELLENT RESULTS IN 48 FRACTURES. VERY GOOD RESULTS IN 6, WITH GOOD IN 4 AND WITH POOR IN 1. THE STUDY CONSISTS OF 4 PARTS. …
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Developing novel prophylactic approaches against SARS-CoV-2 infection
… remain elusive, partly due to low ACE2 levels in experimental models. To address this challenge, I use biliary epithelial cell (cholangiocyte), one of the cell types with the highest ACE2 levels, to dissect the molecular mechanisms controlling ACE2 expression. I identify the farnesoid X receptor …
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Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias
… are difficult to study in man. The current experimental models are arrhythmias induced by electrical stimulation, coronary artery ligation or by subsequent reperfusion. An electrophysiological model will be useful for exploring the cellular mechanism of arrhythmias and for studying the …
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Pericytes in Early Vascular Development
… cells are recruited and interact in several experimental models. Thus, to thoroughly analyze the morphology of these vessels, we developed a rigorous methodology using a MATLAB program to determine the colocalization and coverage of pericytes associated with vessels in large image sets. After …
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Rivals in the sky : the developmental relationship between the airship and the airplane.
… War. Airplanes and seaplanes quickly moved from experimental models to commercial and military dominance. While the two systems of flight started at about the same time, the airplane evolved into the most prolific method of aerial travel in North America, Europe, South America, Australia, and …
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Interactions between influenza A virus and Streptococcus pneumoniae in nasal colonization and middle ear infection
… to the incidence of otitis media in children and experimental models have identified numerous mechanisms by which viral infection predisposes to increased pneumococcal infection. Unclear, however, are the roles of specific pneumococcal factors in this coinfection process. This study was undertaken …
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The application of impact dampers to continuous systems
… finite numbers of degrees of freedom.</p> <p>Experimental models were tested in the laboratory and finite element computer programs were developed to calculate response. Results from calculations agree favorably with experimental tests. Further, results from the first few natural modes also …
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Spatial dynamics of microbial populations driven by social interactions and horizontal gene transfer
… we use synthetic microbial consortia as our experimental models, to explore the factors contributing to the microbial populations’ spatial dynamics, owing to their great controllability and reduced system complexity compared to native existing ecosystems. Upon a systematic investigation on …
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