Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"Experimental autoimmune encephalomyelitis"”.
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… animal model of multiple sclerosis (MS), called experimental allergic encephalomyelitis (EAE). MS is an autoimmune disease characterized by infiltration of myelin reactive immune cells into the central nervous system (CNS) that is more prevalent in genetically susceptible women compared to men. …
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Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
… TH1 differentiation and reduce the severity of experimental autoimmune encephalomyelitis (EAE), presumably by affecting Notch signaling. To understand the mechanisms through which γSI alter autoimmune T cell responses, we utilized an adoptive transfer model of EAE. We found that γSI treatment in …
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Targeting gene therapy to neuroinfalmmatory lesions in experimental autoimmune encephalomyelitis
… des Rückenmarks. In Mäusen mit experimenteller autoimmuner Enzephalomyelitis (EAE), einem Modellsystem für Multiple Sklerose (MS), führte die intravenöse Verabreichung der GFP-positiven Stammzellen zu deren spezifischen Migration zu Entzündungsläsionen im Rückenmark. Diese Migration korrelierte …
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Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis
… complex (MHC), imposes susceptibility for autoimmune disease is not fully understood. A small fraction of TCR α or β chains are “public”, and are shared by most individuals.High-throughput sequencing of the mouse TCRβ repertoire during myelin oligodendrocyte glycoprotein (MOG)-induced …
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The Effects of Immunomodulatory Agents On the Development of Experimental Autoimmune Encephalomyelitis
<p>Multiple Sclerosis (MS) is a neurodegenerative autoimmune disease that affects about 400,000 people in the US and close to 2 million people worldwide. Although the direct cause of this disease remains unknown, it has been demonstrated that CD4+ T-cell subsets Th1 and Th17, play a significant …
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The pathological role of acrolein in experimental autoimmune encephalomyelitis and multiple sclerosis
<p>Multiple sclerosis (MS) is an autoimmune demyelinating neuropathy that affects nearly 2.5 million people worldwide. Despite substantial efforts, few treatments are currently available largely due to limited knowledge of pathogenic mechanisms underlying the disease. The immune-inflammatory nature …
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The intersection of pain, disease severity, and circadian disruption in experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is an autoimmune disease causing neuroinflammation and demyelination to the central nervous system. The overall goal of this thesis was to explore an emerging area of research in the MS field: circadian rhythms, the 24-hour biological rhythms governing a significant number …
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Effects of Puberty and Obesity on Central Nervous System Autoimmunity in Experimental Autoimmune Encephalomyelitis
… 2) and adolescent obesity (Chapter 3) increase autoimmune susceptibility in the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). First, EAE development was compared between age-matched SJL/J mice that differed only by pubertal status. It was observed that puberty in females, …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… investigated a very different aspect of the autoimmune response to MOG, the consequences of immunological cross-reactivity with BTN, a major component of the milk fat globule membrane. The demonstration of cross-reactive T cell responses between MOG and a dietary antigen opens a new …
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Upper-respiratory infection triggers experimental autoimmune encephalomyelitis onset in autoimmune prone t-cell receptor transgenic mice
Multiple Sclerosis (MS) is an autoimmune-mediated demyelinating and neurodegenerative disease of the central nervous system. Most MS patients experience a disease course characterized by periods of symptom exacerbation (relapses) followed by periods of partial recovery (remission). Relapse …
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Investigating Potential Quantitative Trait Loci for Susceptibility to Experimental Autoimmune Encephalomyelitis in the BXD Family of Mice
Multiple Sclerosis is an autoimmune inflammatory condition that causes disability, axonal damage in the central nervous system, and eventual paralysis. One of the main risk factors for developing MS is genetics, with recent studies identifying multiple risk alleles associated the major …
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Influenza A virus modulates the severity of relapsing-experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Immunomodulatory effects of the filarial nematode product, ES-62, and phosphorylcholine-based small molecule analogues S3 and S5 in experimental autoimmune encephalomyelitis
Background: Multiple sclerosis (MS) is an autoimmune inflammatory disease of which the pathophysiology includes pro-inflammatory responses of CD4+ T cells and macrophages and their associated cytokine cells with episodes of demyelination. The filarial nematode excretory secretory product ES-62 has …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
The ultimate goal in the treatment of autoimmune diseases is to reestablish tolerance to self antigens. One strategy to induce tolerance is to express the target autoantigen by DNA vaccination. In this work, the potential of vaccination with a DNA construct encoding the myelin oligodendrocyte …
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The bi-directional relationship between gut microbiota and autoimmunity
… a bi-directional relationship. Here, we utilize experimental autoimmune encephalomyelitis, a model for multiple sclerosis, to explore the bi-directional relationship that disease and microbiota share. We demonstrate that disease severity, as well as time point post disease induction, shapes the …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… such cells and have been proven to suppress autoimmune encephalomyelitis, the murine model of multiple sclerosis. We here demonstrate the ability of humanized chimeric receptors to suppress experimental autoimmune encephalomyelitis (EAE) in a humanized mouse model by redirecting T lymphocytes …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
In this project two novel murine autoimmune models were to be established in an attempt to further investigate the nervous system disorders of Multiple Sclerosis and Guillain Barré Syndrome. Previous experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN) models …
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THE INNATE CYTOKINE IL-18 INHIBITS CNS AUTOIMMUNITY THROUGH PREFERENTIAL ACTIVATION OF PROTECTIVE CD8 T-CELLS
… with certain autoinflammatory, but not autoimmune, diseases. We tested how excess IL-18 affected susceptibility to experimental autoimmune encephalomyelitis (EAE), a model of CNS autoimmunity driven by IL-18 responsive, myelin-autoreactive CD4T-cells (CD4Tauto). Prior data suggested that …
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