Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 109 for “"Exosomes"”.
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Identification and Utility of Dna In Exosomes
… especially in the early stages of disease. Exosomes on the other hand, are phospholipid nanovesicles that reflect the molecular contents of their cell of origin and are abundantly present in bodily fluids. Due to this, exosomes have attracted considerable interest as a source for theranostic …
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Identification and Molecular Analysis of Dna In Exosomes
<p>Exosomes are heterogeneous nanoparticles 50-150nm in diameter. Exosomes contain many functional cargo components, such as protein, DNA, and RNA. While protein and RNA exosome content has been extensively studied, very little work has been done to characterize exosomal DNA. Here, we demonstrate …
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
… that cancer cells secrete vesicles called tumor exosomes (TEX) which are loaded with bioactive molecules which strongly influences the tumor microenvironment. Both protein and mRNA of the IAP Survivin, cIAP1, cIAP2 and XIAP are released into the extracellular space by not only the pancreatic …
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The Tumor-Suppressive Role Of Secreted Maspin Via The Exosomes
… maspin has been reported as cargo of the exosomes, which highlights one of the secretion mechanisms of maspin. Maspin secretion as an exosomal molecule was verified by electron microscopy, atomic force microscopy, light scattering dynamic analysis and immunoblot analysis.</p> <p>The data …
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Proteomic Profiling of Serum Derived Exosomes from Prostate Cancer Patients
… clinical impact. We hereby examined the role of exosomes in PCa and a qualitative profile of its proteomic composition. The higher levels of circulating exosomes in sera of PCa patients is directly prostate-derived and could be stress-induced as the non-cancer prostate stroma and the immune …
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Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Selektiver Transfer von Exosomen von Oligodendrozyten zu Mikroglia durch Makropinozytose Oligodendrozyten sind die Myelin-bildenden Zellen des zentralen Nervensystems. Dieser Zelltyp bildet während der aktiven Phase der Myelinisierung große Mengen an Zellmembran aus. Zusätzlich werden …
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Exosomes act as molecular vehicles contributing to cellular cholesterol efflux
Exosomen sind Vesikel mit einer Größe von 50-100 nm, welche den intraluminalen Vesikeln der multivesikulären Endosomen (MVE) entsprechen und bei der Fusion von MVE mit der Plasmamembran in die extrazelluläre Umgebung sekretiert werden. Die Sekretion von Exosomen konnte für eine Reihe von …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
Exosomes/extracellular vesicles (EVs) are cell-derived mixed-populations of vesicles released by almost all cells into the intercellular microenvironment, ending up in the circulation. Exosomes contain proteins, RNAs and lipid molecules reflecting the status of the parental cell at the time of …
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Cd47+ Exosomes Facilitate Effective Targeting of Oncogenic Kras In Pancreatic Cancer
… delivery system. Therefore, we probed whether exosomes could function as an efficient carrier of RNAi molecules. Exosomes are nano-sized extracellular vesicles (40-150nm) with a membrane lipid bilayer that are released by all cells of the body and efficiently enter other cells. Therefore …
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Exosome-Mediated Protection Against Oxidative Stress: A Connection Between NRF2 And Exosomes
… target genes encode for proteins loaded into exosomes [1]. Exosomes are extracellular microvesicles that are secreted by cells in response to a variety of stimuli, including many stressors. Exosomes serve as a transport mechanism for proteins, RNA, DNA, and other molecules. Therefore, we …
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Curcumin: A Multi-dimensional Approach to Pancreatic Cancer Targeting Cell Death and Exosomes
… intercellular vesicular signaling through exosomes, resulting in tumor growth and progression. However, recent studies have shown that exosomes can also be used as a delivery mechanism for drugs with poor bioavailability, thus providing a therapeutic advantage for these compounds. …
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Investigation of Cancer Stem Cells (CSCs)-derived exosomes and their influence on the tumor microenvironment
Exosomes are membrane nanovesicles of endocytic origin that can be released to the extracellular environment by many different cells, included the tumor cells. Exosomes have been suggested to have a number of different functions and are believed to take part in the communication between cells. The …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
… Recently, extracellular vesicles, especially exosomes, have been highlighted for their therapeutic benefits in numerous chronic diseases such as cancer. Exosomes display multifunctional properties, including inhibition of cancer cell proliferation and initiation of apoptosis. Hence, this study …
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The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma
… Recently, extracellular vesicles, especially exosomes, have been highlighted for their therapeutic benefits in numerous chronic diseases such as cancer. Exosomes display multifunctional properties, including inhibition of cancer cell proliferation and initiation of apoptosis. Hence, this study …
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LncRNA and circRNA expression profiles in tissues and serum exosomes of colorectal cancer patients and cell lines
… to normal adjacent tissues (NATs), and in serum exosomes of 20 CRC patients compared to 20 healthy individuals. We identified 8 ncRNAs (CCAT1, CCAT2, CDR1AS, HOTAIR, MALAT1, TUG1, UCA1 and ZEB2AS1) differentially expressed (DE) in tissues and 3 ncRNAs (circ16, TUG1 and UCA1) DE in serum exosomes. …
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Development of a multi-stage purification process for serum-derived exosomes and evaluation of their regenerative capacity
Exosomes are secreted membrane vesicles (30-100 nm) found in tissue culture media and various body fluids that have potential as therapeutics and disease biomarkers. Current literature has reported regenerative benefits for blood-derived exosomes but the majority of these studies purified exosomes …
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Identification of exosomal proteins in primary human bronchial tracheal epithelial cell HBTE and the H358, THP1 and MCF7 cell lines
… New sources of biomarkers are needed to improve. Exosomes are nano sized extracellular vesicles released by almost all cells have gained much interest as a cancer biomarker source due to their ability to transfer genetic materials, stability and ease of availability. Aims: The aim of this study is …
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The effect of stressed cell-derived exosomes on metastatic activity of ovarian and breast cancer cell lines in vitro
… vesicles. Of these secreted vesicles, exosomes have been studied extensively over the past decade. Exosomes are between 30–100 nm in diameter and contain protein and nucleic acids. They have only very recently become appreciated as communication mediators that transport signals between …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… the mechanism through which CBSC-derived exosomes altered wound healing and reduced scar formation through in vitro experimentation and in an in vivo post-I/R study in mice. The effects of CBSCs and CBSC-derived exosomes on cardiac fibroblasts was determined. The aim was to broaden our …
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