Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"Exosome"”.
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Molecular mechanisms of exosome secretion
Exosomes are small (30-150 nm) extracellular vesicles (EVs) that obtain their membrane through the inward invagination of the endosomes, which are known as multivesicular endosomes (MVEs). Exosomes are secreted to the extracellular milieu when MVEs dock and fuse with the plasma membrane. However, …
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Genetic Analysis of Rna Exosome Complex Cofactors
<p>The RNA exosome complex is known to process and/or degrade many classes of RNA, including mRNA, rRNA, tRNA and snRNA, through its 3’-to-5’ exoribonuclease catalytic activity. The RNA exosome complex comprises a 9-unit core (exo-9), with six proteins making up a PH-Ring barrel and three proteins …
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Development of exosome-based anti-cancer therapeutics
Hepatocellular carcinoma (HCC) exosomes are found to be responsible for cancer progression, metastasis, and angiogenesis via cellular communications. However, studying cancer derived exosomes in vitro is limited, due to the way cell lines are grown in medium supplemented with foetal bovine serum …
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Exosome Prevention of Post Operative Atrial Fibrillation
Almost half of patients recovering from open chest surgery experience atrial fibrillation (AF) that results principally from inflammation in the pericardial space surrounding the heart. Given that post-operative AF is associated with increased mortality, effective measures to prevent AF after …
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Mechanisms of Multivesicular Body Biogenesis and Exosome Release
Exosomen sind kleine Vesikel mit einem Durchmesser von ca. 50-100 nm, die von vielen Zellarten sezerniert werden und verschiedene interzelluläre Signalprozesse koordinieren. Nach der Fusion von multivesikulären Endosomen (MVE) mit der Plasmamembran werden die intraluminalen Vesikel (ILV) als …
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Exosome- and Microrna-based Therapeutic Approach for Tendinopathy
… to paracrine actions, including some mediated by exosomes – extracellular vesicles secreted by cells that play a role in cell communication. MicroRNA (miRNA), small non-coding RNA carried by exosomes, are likely responsible for many exosome effects. Exosomes and miRNA therapies show promise in …
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Investigating Spatiotemporal Kinetics, Dynamics, and Mechanism of Exosome Release
<p>Exosomes are small lipid-based vesicles that can carry biomolecules from one cell to another. While exosomes are crucial to maintain homeostasis in healthy cells, they are exploited by unhealthy cells to aid disease progression. Exosomes likely facilitate disease progression via the transfer of …
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The Role of The Arched Helicases In Exosome-Mediated Function
… cell. A major ribonuclease complex, called the exosome, is involved in both of these processes. The exosome is composed of ten essential proteins with only one catalytically active subunit, called Rrp44. While the same ten essential subunits make up both the nuclear and cytoplasmic exosome, …
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Designer DNA Condensates: From Multiphase Architectures to Synthetic Exosome Release
… of this thesis focuses on integrating synthetic exosomes within these engineered DNA phase-separated condensates. I demonstrate the capability to programmatically localise synthetic exosomes either inside or outside the DNA condensates. Critically, I achieve their controlled release in response …
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The potential of exosome-based gene therapy to eradicate glioblastoma cells
… by their safety and toxicity profiles. Exosomes, cell-produced nanosized vesicles, have emerged as a new potential carrier for gene therapies in cancer treatment due to their natural material transport properties, biocompatibility, and specificity in transporting cargo to the target …
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Feto-Maternal Exosome Characterization, Trafficking and Function During Pregnancy and Parturition
… feto-maternal signaling via exosomes. Oxidative stress in utero, most likely due to increased metabolic activity of the fetus, induces cellular senescence of the fetal membranes. We have reproduced this model in vitro to show human amnion epithelial cells can produce exosomes …
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Identifying Subunit Organization and Function of The Nuclear Rna Exosome Machinery
… ORGANIZATION AND FUNCTION OF THE NUCLEAR RNA EXOSOME MACHINERY </strong></p> <p><strong>Jillian Strother Losh, A.S., B.S. </strong></p> <p>The eukaryotic RNA exosome processes and degrades many classes of RNA. It is present in the nucleus and the cytoplasm, highly evolutionarily conserved, and …
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DIABETES IMPAIRS THERAPEUTIC EFFECT OF ENDOTHELIAL PROGENITOR CELL EXOSOME-MEDIATED MYOCARDIAL REPAIR
… models. Lately, emerging evidence supports that exosomes (Exo), a family of extracellular vesicles, mediate stem cell therapy by carrying cell-specific biological cargo and by inducing signaling via transferring of bioactive molecules to target cells. Despite promising results of stem cells/Exo …
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Effect of cmvIL-10 on Exosome Production by Human Breast Cancer Cells
… women in North America, usually from metastasis. Exosomes are 30-100nm vesicles produced by most cells which carry protein and RNA to cells in their microenvironment. The aim of this study is to investigate the impact of HCMV-infection of a secreted viral cytokine, cmvIL-10, on exosome production …
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Exosome-Mediated Protection Against Oxidative Stress: A Connection Between NRF2 And Exosomes
… target genes encode for proteins loaded into exosomes [1]. Exosomes are extracellular microvesicles that are secreted by cells in response to a variety of stimuli, including many stressors. Exosomes serve as a transport mechanism for proteins, RNA, DNA, and other molecules. Therefore, we …
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Characterization of The Rna Binding and Rna Degrading Subunits of The Eukaryotic Exosome
<p>The exosome is an essential complex of ten proteins involved in the processing and degradation of many RNAs in the cell. These include various stable RNAs, mRNAs, and aberrant transcripts both in the nucleus and in the cytoplasm.</p> <p>In this work I characterize the three members of the …
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Functional Consequences of Rna Exosome Complex Alteration By Conformational Changes and Cofactor Binding
<p>The RNA exosome is an essential 3’-5 ribonuclease that processes or degrades a variety of RNA species in eukaryotes. It is composed of nine structural cores and one catalytic subunit, Rrp44. Structural studies captured two different conformations of Rrp44, Rrp44<sup>ch</sup> (channel) and …
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Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases
<p>Functions of RNA exosome and tRNA splicing ligase in Mendelian and Infectious diseases</p> <p>Khondakar Sayef Ahammed, M.S.</p> <p>Advisory Professor: Ambro van Hoof, Ph.D.</p> <p><strong> </strong></p> <p>RNA maturation and degradation reactions are important for health and survival of all …
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Cell-free DNA and tumor exosome cargo as diagnostic and prognostic marker for prostate cancer
… characterize plasma and urinary cfDNA and tumour exosome cargo as diagnostic biomarker for PCa in South African populations with the goal of discovery of reliable, non-invasive, and novel biomarkers of PCa. We performed miRNA sequencing of exosomal RNA extracted from high and low Gleason's score …
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The Domains of The Catalytic Subunit of The Eukaryotic Rna Degrading Exosome, Rrp44P, Have Distinct Functions
The exosome is a 3’ to 5’ exoribonuclease complex that consists of ten essential subunits. In the cytoplasm, the exosome degrades mRNA in a general mRNA turnover pathway and in several mRNA surveillance pathways. In the nucleus, the exosome processes RNA precursors to form small, stable, mature RNA …
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