Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Exoribonucleases"”.
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Unifying the features that determine substrate preferences of nanoRNases
… function. Specific subsets of endo- and exoribonucleases catalyze the reactions that ultimately replenish the pool of mono-ribonucleotides. While exoribonucleases largely share overlapping substrates and functions, nanoRNases are unique in that they alone degrade short RNA fragments in a …
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Design, Construction, and Screening of an shRNA Library Targeting Human Circular RNAs
… circRNAs have no ends and are not sensitive to exoribonucleases, endowing circRNAs with a longer half-life. This enhanced stability has prompted the study of circRNAs as cancer biomarkers. While expression studies are becoming widely used to profile circRNAs in multiple cancers, there are no …
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Analysing the role of SAL1/PAP retrograde signalling within the circadian system of Arabidopsis thaliana
… stress and inhibits the activity of 5’→3’ exoribonucleases (XRNs). This study shows that genetically inducing the SAL1-PAP-XRN pathway in plants lacking SAL1 function induces a long circadian period in a blue light-dependent manner. Application of exogenous PAP or osmotic stress lengthens …
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Analyzing the functions of human polynucleotide phosphorylase (hPNPaseold-35)
… processing to generate mature transcripts. 3’-5’ exoribonucleases are essential mediators of RNA decay pathways, and one such evolutionarily conserved enzyme is polynucleotide phosphorylase (PNPase). The human homologue of this fascinating enzymatic protein (hPNPaseold-35) was cloned a decade ago …
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Investigating the Role of DIS3L2 in Perlman Syndrome and Wilms Tumor
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.