Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Exocrine Pancreas"”.
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The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
The exocrine pancreas comprises about 98% of the total pancreatic tissue. Its main function is the synthesis and secretion of digestive enzymes in order to facilitate nutrient absorption upon feeding. This function is mainly carried by acinar cells that require strict regulation of protein …
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The action of magnesium upon stimulus-secretion coupling in the exocrine pancreas
… the regulation of magnesium homeostasis in the exocrine pancreas under agonist stimulation (b) that secretagogueevoked cellular processes in the exocrine pancreas are sensitive to physiological changes in Mg2+ and (c) the intracellular roles of Mg2+ in the secretagogue-evoked exocytotic …
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Biomimetic platforms for modeling in vitro the functional unit of the exocrine pancreas
… pancreatic cancer, is the most frequent type of exocrine pancreas tumors and one of the leading causes of cancer-related death worldwide with a five-year survival rate around 10%. The main reason that leads to consider PDAC a notably aggressive disease concerns the rapid cancer’s evolution …
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Stimulus-secretion coupling in the exocrine pancreas of the rat: Interactions between secretagogues
… juice secretion (CCK8 & Secretin) in the rat pancreas. 2. Modifications in extracellular Mg 2 affected ACh-evoked 45Ca2 influx, efflux and intracellular free C a2+ mobilisation. Elevated extracellular Mg2+ (10 mM) depressed whereas, zero extracellular Mg2+ (0 mM) augmented these parameters in …
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The effects of histamine on the gallbladder and exocrine pancreas of the guinea-pig
… and contractile actions of histamine on the exocrine pancreas and gallbladder of the guinea-pig respectively. Application of histamine to the isolated gallbladder strip elicited contraction Of the tissue. This net effect of histamine was subsequently found to be a result of stimulation of two …
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RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
… transcription factor, which is essential for pancreas development and function. Mice lacking both p48 alleles lack an exocrine pancreas and have a greatly reduced endocrine pancreas. The active form of P48 is the heterotrimeric complex, PTF1. This complex binds and regulates the transcription …
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Investigating the role of the basic helix-loop-helix transcription factor MIST1 in pancreatic diseases
<p>Acinar cells of the exocrine pancreas are dedicated to synthesize, package and secrete immense quantities of pro-digestive enzymes to maintain proper metabolic homeostasis for the organism. Dysregulation of enzyme secretion in acinar cells can give rise to exocrine diseases including acute …
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Early liver formation in zebrafish: a molecular and morphological approach
… tract and its accessory organs - liver, pancreas, and the inner lining of the swim bladder - are derived from the endodermal germ layer. In zebrafish the digestive system starts out as a rod at the embryonic midline, which subsequently becomes patterned and outgrowth of its associated …
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Evaluation of the induction of rat hepatic and pancreatic glutathione S-transferases by treatment with the cruciferous nitrile, cyanohydroxybutene
… per os, CHB is selectively toxic to the rat exocrine pancreas. At this and non-toxic doses, CHB causes the sustained elevation of GSH in the liver and pancreas. The elevation, which follows a brief depletion phase, is associated with the induction of the hepatic GSH synthesizing enzyme, …
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Oncofetal Proteins Drive Aggressive Disease in Basal Pancreatic Cancer
… (PDAC) is a deadly cancer arising from the exocrine pancreas. Unlike most other solid tumors, incidence and mortality from PDAC continues to rise in the United States. PDAC is typically diagnosed after it has metastasized to other organs, and the only treatment option for advanced disease is …
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Understanding the Role of Hypusine Biosynthesis in Endocrine-Exocrine Crosstalk
Traditionally, the exocrine and endocrine cellular compartments of the pancreas have been considered distinct functional systems. However, recent studies suggest a more intricate relationship between the exocrine and endocrine, which may impact pancreatic growth and health. Additionally, …
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The Role of Microtubules in Secretion
… to the cell membrane in a variety of both exocrine and endocrine cells. A range of roles, from provision of the motive force to preventing presecretory movement, have been attributed to these organelles. An in vitro model system to investigate the interaction between isolated exocrine …
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Acute Pancreatitis. Studies on smoking and protease activation.
… special attention and the effect of nicotine on exocrine pancreas was studied in a rat model. Results and conclusions: Cathepsin B activated trypsinogen but not proelastase or procarboxypeptidase B. Hence, if cathepsin B is to play a role in the activation of digestive enzymes in acute …
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Novel biomarker identification in pancreatic cancer using Raman spectroscopy
… of healthy and cancerous tissue in the exocrine pancreas. SPARC has been shown to play a role and be expressed in the development of pancreatic cancer and has recently been identified as a potential biomarker for the disease. Raman spectroscopy is an emerging technology, showing promise …
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The Effect of Insulin on the Nitrogen Metabolism of Teleost Fishes
… closely associated with the ducts of the diffuse exocrine pancreas and thus are present throughout the pleuroperitoneal cavity: The islets are discrete rounded richly vascularized bodies occurring in greater numbers around the cystic duct common bile duct and the gall bladder. Two distinct cell …
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Influence of magnesium on salivary gland secretion: physiological and pathophysiological studies
… of epithelial secretory cells including the exocrine pancreas, lachrymal and the parietal cells. Since the salivary glands acinar cells have a similar structure and function as the exocrine pancreas, the stomach and the lachrymal gland, it was decided to investigate specifically the effect of …
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Advanced Microfluidic Platforms for Studying the Stromal Compartment of Pancreatic Cancer Tumor Microenvironments
… adenocarcinoma (PDAC) is a deadly disease of the exocrine pancreas, with treatment resistance attributed to the aggressive biology of the tumor microenvironment (TME). Interactions between activated pancreatic stellate cells (PSCs) and pancreatic cancer cells (PCCs) give rise to dense fibrotic …
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