Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Executioner"”.
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A planner/optimizer/executioner for content mediated queries
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
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Capabilities aware planner/optimizer/executioner for COntext INterchange Project
Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.
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Judge, jury, and executioner: organizational factors that affect police use of lethal force
There currently exists an empirical gap in our knowledge of organizational factors as they relate to police use of lethal force. As a result of waning interest in macrolevel policing studies over the last three decades, the majority of our understanding of lethal force is derived from studies that …
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Transient receptor potential melastatin member 4 is the executioner protein for anticancer drug-induced necrotic cell death
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Investigating Apoptosis Pathway In Chronic Lymphocytic Leukemia: Stromal Influence and Therapeutic Activation
… this study involved therapeutic manipulation of executioner caspases in restoring apoptotic pathway that is frequently blocked by upstream anti-apoptotic Bcl-2 family members. A novel therapeutic approach that can potentially bypass the functional pro-survival proteins and directly activate …
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Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
… resist execution of apoptotic cell death by the executioner caspase (caspase-3). Paradoxically, the zymogen of the executioner caspase, procaspase-3, rather than being downregulated in cancer, has been found to be overexpressed in many cancers. In Chapter 1, I will describe the list of cancers …
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Islet Dysfunction In Diabetes
… endoplasmic reticulum [ER] - mitochondria axis, executioner caspases and their target substrates; specifically nuclear lamins. </p> <p>Results obtained from our studies in pure beta cells [INS-1 832/13], primary rodent and human islets strongly suggest that glucotoxicity induced pancreatic beta …
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Karel Huss a pověrčivost
… and legacy of its author, Karel Huss, the last executioner of the city of Cheb, they have not sufficiently captured Huss's personal traits and subjectivity in perceiving superstitions, that gave rise to prejudices, which Huss grappled with throughout his life. The interpretation is based on a …
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The discovery and characterization of anticancer procaspase activating compounds
… extrinsic pathways converge on the activation of executioner cysteine aspartate proteases caspases-3 and -7. However, cancer cells are able to escape apoptosis through mutations which render the key apoptotic proteins inactive or aberrantly expressed. Paradoxically, procaspases are generally …
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Information integration using contextual knowledge and ontology merging
… integrated capabilities-aware planner/optimizer/executioner. The second challenge, data interpretation, deals with the existence of heterogeneous contexts, whereby each source of information and potential receiver of that information may operate with a different context, leading to large-scale …
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Investigating procaspase-3 as a potential therapeutic target in canine osteosarcoma
… cascade. The central role of capsase-3 as an executioner of apoptosis makes it an ideal drug target for circumventing such upstream disruptions and restoring effective apoptosis in cancer cells. This work investigates the use of PAC-1, a newly developed procaspase-3 activating compound, in the …
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Take heed what ye hear : Shakespeare's "Measure for measure" and the Bible.
… particularly its embodiment in Abhorson the executioner. And finally, Chapter Eight concludes the dissertation with a reading of the Duke as figuring Christ.
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"Desmantelamiento e integracion de las dicotomias en ""Cien anos de soledad"""
… their lives (love/hate; liberal/conservative; executioner/victim) are but empty linguistic manifestations of a same lack and a same solitude. This interpretation is consistent with the very formal configuration of the text: the combination of realism and myth characteristic of ""magical …
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Une approche afin de produire les différentes conformations de caspase-7 tout en contrôlant l'induction de l'apoptose
… (caspases-3, -6 and -7). During apoptosis, executioner caspases are cleaved by initiator caspases either by the extrinsic (death receptors) or by the intrinsic (mitochondrial) pathway of caspase activation. Caspase-7 is an obligate dimer in the cell and cleavage of the interdomain connector …
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Nanosecond Pulsed Electric Fields Induce a Mitochondria-Independent Apoptosis in B16F10 Melanoma Cells <i>In Vitro</i>
… in caspases -8 and interestingly -9 as well as executioner caspases -3, -6 and -7.</p> <p>NsPEFs activate signal transduction mechanisms that induce apoptosis through a mitochondria independent pathway that mimics an apparent membrane-dependent extrinsic type I apoptotic mechanism(s). Uniquely, …
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NEW INSIGHTS INTO THE REGULATION OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION DURING APOPTOSIS
… strongly suggest that Fas-mediated activation of executioner caspases and induction of apoptosis does not depend on apoptosome-mediated caspase-9 activation in prototypical type II cells. In the third aim, mitochondrial apoptotic events were examined after prolonged treatment with etoposide ( 6 …
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… These findings place GSDMB as a central executioner of intracellular bacterial killing and reveals a mechanism employed by pathogens to counteract this host defense system.
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… in macrophage that cleaved GSDMD, the executioner of cell pyroptosis, leading to the insertion of N-terminal effector domain into the cell membrane, driving both pore formation and IL-1β secretion without causing significant cell death. In this study, I interrogated the requirements and …
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Development of PAC-1 as a privileged agent for combination chemotherapy
… Building upon the success of dual targeting of executioner caspases for enhanced apoptotic effect, PAC-1 was investigated as a method to broadly enhance diverse pro-apoptotic signals. Excitingly, increased anticancer activity was observed broadly in models of increasing complexity and clinical …
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Mechanisms of Controlled Proteolysis during Drosophila Spermatogenesis: Coordinate Action of Apoptotic Caspases and the Ubiquitin-Proteasome System
… regulation is the activation of its primary executioner: the caspase. This family of proteolytic enzymes has been shown to be tightly controlled, as many different proteins govern their transcription, stability, activation, and activity. Consequently, caspase regulation is extremely complex, …
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