Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 462 for “"Excitatory"”.
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Molecular Mechanisms Controlling Excitatory Synaptic Transmission
… receptors on another. In the case of excitatory synapses, the predominant neurotransmitter, L-glutamate, binds to postsynaptic AMPA receptors (AMPARs). Crucially, synaptic strength is plastic, and control of this strength is essential for fundamental brain functions such as the …
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Regulation of Endogenous Excitatory Neurotransmitters by Isoprostanes
… (IsoPs) regulate exogenously applied excitatory amino acid neurotransmitter glutamate in bovine retina, in vitro. However, the regulation of retinal endogenous glutamateby IsoPs is unknown. The objective of the present study was to investigate the effect of 8-isoprostaglandin E2 …
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Neurologin Function in Excitatory and Inhibitory Synapses
Neuroligins (NLs) are postsynaptic cell adhesion molecules which by binding to presynaptic neurexins (NRXs) are thought to mediate synapse formation and function. Both NLs and NRXs are discussed in the genetic correlation to Autism. Over-expression of NLs could induce the formation of synaptic …
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Synaptic Excitatory to Inhibitory imbalance in Alzheimer’s Disease
… through synaptic abnormalities that disturb the excitatory/inhibitory balance (E/I ratio) in circuits vulnerable to Alzheimer’s disease pathology. We measured electrophysiological, anatomical, transcriptional, and cellular E/I ratios in human brain. Our findings establish a strong correlational …
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Visualizing inhibitory and excitatory synapse dynamics In vivo
… know that even in the mature brain inhibitory or excitatory connections can be made and broken, modifying the information flow within a circuit by enabling or removing specific information channels. However, the properties of inhibitory and excitatory synapse dynamics are not well understood. To …
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MeCP2 and the Epigenetic Regulation of Excitatory Synaptic Transmission
… in deficits in both spontaneous and evoked excitatory synaptic transmission. Using pharmacological manipulations, we were able to attribute these deficits to the loss of transcriptional repression by MeCP2. By utilizing a conditional knockout approach, we found that these effects were not …
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Cannabinoid regulation of excitatory synaptic transmission at hippocampal synapses
… and site of cannabinoid-mediated actions on excitatory synaptic transmission (Bajo et al., 2009). Therefore, the aim of this study was to investigate the effects of cannabinoids on excitatory synaptic transmission at different hippocampal CA1 synapses.<br/><br/>In this study, standard …
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AMPA receptor diversity and dynamics during excitatory synaptic transmission
… of AMPARs therefore determines the fidelity of excitatory synaptic transmission and enables synaptic plasticity. Distinct functional properties are conferred on the AMPAR tetramer by the choice of core subunit (GluA1-4), as well as their association with various auxiliary subunits. Using results …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS that can mechanistically contribute to either neuronal signaling or neuronal pathology. Consequently, its concentration in the CNS must be carefully regulated, a critical need that is met by the excitatory amino acid …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS that can mechanistically contribute to either neuronal signaling or neuronal pathology. Consequently, its concentration in the CNS must be carefully regulated, a critical need that is met by the excitatory amino acid …
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The synthesis and pharmacology of novel excitatory amino acid mimetics
… and aspartic acids are considered to be potent excitatory amino acid neurotransmitters of vertebrates. Receptors for these amino acids may be sub-divided into three types: (i) Quisqualate/glutamate, (ii) N-methyl-D-aspartate (NMDA) and (iii) Kainate type. The aim of this project has been to …
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Excitatory synaptic transmissions in striatal neurons after transient global ischemia
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Age-dependent regulation of hippocampal excitatory synaptic transmission by leptin
… demonstrate that leptin can regulate hippocampal excitatory synaptic transmission in an age-dependent manner at Schaffer collateral (SC)-CA1 synapses (Moult and Harvey, 2011). In addition, recent evidence indicates that leptin can also regulate synaptic transmission at the anatomically distinct …
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Effect of Background Synaptic Activity on Excitatory-Postsynaptic Potential-Spike Coupling
<p>Neurons receive large amount of synaptic inputs <em>in vivo</em>, which may impact the coupling between EPSPs and spikes. We mimicked the<em> in vivo</em> synaptic activity of the cell with the dynamic clamp system. We recorded from pyramidal cells in neocortical slices<em> in vitro</em> to …
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The synthesis and pharmacology of some novel excitatory amino acid analogues
… L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These receptors have been named after the most potent …
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Estrogenic modulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses
… these synapses, estrogen can rapidly potentiate excitatory synaptic transmission (Oberlander and Woolley., 2017). The actions of estrogen at the anatomically distinct Temporoammonic (TA)-CA1 synapse is not as well established, however initial studies indicate that estrogen can robustly enhance …
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Strength and dendritic organization of thalamocortical synapses onto excitatory layer 4 neurons
… differences between these inputs onto excitatory L4 neurons in vivo. We developed a high-throughput light microscopy method, validated by electron microscopy, to completely map the locations of synapses across an entire dendritic tree. This demonstrated that TC synapses are slightly …
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