Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Excitation-Inhibition"”.
-
Imaging Chloride Homeostasis in Neurons
… and they are often co-modulated during excitation-inhibition activity. The study of their homeostasis requires simultaneous measurements in vivo in multiple neurons. Combining random mutagenesis screening, protein engineering and two-photon-imaging this thesis work led to the discovery …
-
The Emergence of Network Hyperexcitability and Functional Impairment in a Mouse Model of Alzheimer’s Disease
… mechanistic driver. Finally, to further explore excitation-inhibition balance in vitro, pharmacological intervention with a novel GABAΑ-R α1-selective nanobody, acting as a positive allosteric modulator, was shown to decrease activity in WT networks but paradoxically exacerbate burst-driven …
-
Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
… decreases hyperexcitability and normalizes the excitation/inhibition imbalance. The exact mechanism by which tau produces hyperexcitability remains to be determined, but recent work suggests tau may mediate glutamatergic signaling. Glutamate is the primary excitatory neurotransmitter in the …
-
Models of binaural hearing for sound lateralisation and localisation
… pattern-matching (PM) model, assumes that the excitation-inhibition cell activity pattern suggested by Breebaart et al. [J. Acoust. S. Am., 110(2):1074-1088, 2001] provides the internal representation of the sound localisation cues. Given the uniqueness of EI-patterns, the pattern-matching …
-
Inhibitory mechanisms for visual learning in the human brain
… respond to fine differences. Although GABAergic inhibition is known to suppress redundant neuronal populations and tune neuronal representations, its role in visual learning remains largely unexplored. Here, I propose that GABAergic inhibition plays an important role in visual plasticity through …
-
The Neural Underpinnings of Obsessive-Compulsive Disorder: From Adolescence to Adulthood
… and habitual systems, driven by disrupted excitation-inhibition (E/I) balance within corticostriatal circuits. This thesis builds directly on previous work in adult OCD, particularly the findings of Biria et al. (2023), which demonstrated altered glutamate and GABA concentrations in …
-
Synaptic dysfunction, tau spreading, and cognitive resilience through the lens of tau oligomers in Alzheimer’s disease and related dementias
… exert region-specific effects on the synaptic excitation/inhibition (sE/I) ratio, with oligomeric and fibrillar tau associated with a pro-inhibitory shift in the PART hippocampus. Chapter 4 builds on this observation by showing that tauO preferentially target presynaptic and GABAergic …
-
Changes in the Morphology of Hypoglossal Motor Neurons in the Brainstem of Developing Rats
… changes in neurotransmitters, receptors, excitation-inhibition balance, and breathing. However, age-dependent morphological changes of XII MNs during the first three weeks post-birth and especially during this sensitive period, have not been thoroughly studied. In this study, we …
-
Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
… signals, and disruption to the balance of excitation and inhibition (E/I) within CT circuitry leads to absence seizures, sleep disorders, and attention deficits. E/I balance may be restored by independently modulating excitatory CT input to the ventral posteromedial (VPM) thalamus and …
-
Dynamical Systems Analysis of Neural Circuits with Applications to Physiological Processes
… state transitions driven by changes in excitation–inhibition balance, independent of specific model details. The dynamical systems mechanisms characterised here (SNICeroclinic and SNIC²) provide a framework for understanding how perturbations to neuronal circuits induce qualitative …
-
The Role of Gamma Oscillations and Cortical Inhibition In The Development of Working Memory In Adolescence
… gamma-aminobutyric acid (GABA)-mediated cortical inhibition underlies these changes. I hypothesized that cortical gamma-band rhythms would become faster during adolescence in a manner that supports improved working memory capacity, and that the kinetics of cortical inhibition would also become …
-
NEURAL PRECURSOR/STEM CELL-BASED THERAPY: A NOVEL THERAPEUTIC APPROACH FOR THE TREATMENT OF RETT SYNDROME
… and synaptic plasticity together with an excitation/inhibition unbalance. Basic and preclinical studies on RTT have largely benefitted from the use of mouse models mutated in Mecp2. Among these, the most studied is the full knock-out mouse (Mecp2 KO), that recapitulates many RTT features. …