Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Excitation/Inhibition Balance"”.
-
The Emergence of Network Hyperexcitability and Functional Impairment in a Mouse Model of Alzheimer’s Disease
… mechanistic driver. Finally, to further explore excitation-inhibition balance in vitro, pharmacological intervention with a novel GABAΑ-R α1-selective nanobody, acting as a positive allosteric modulator, was shown to decrease activity in WT networks but paradoxically exacerbate burst-driven …
-
Inhibitory mechanisms for visual learning in the human brain
… respond to fine differences. Although GABAergic inhibition is known to suppress redundant neuronal populations and tune neuronal representations, its role in visual learning remains largely unexplored. Here, I propose that GABAergic inhibition plays an important role in visual plasticity through …
-
Changes in the Morphology of Hypoglossal Motor Neurons in the Brainstem of Developing Rats
… changes in neurotransmitters, receptors, excitation-inhibition balance, and breathing. However, age-dependent morphological changes of XII MNs during the first three weeks post-birth and especially during this sensitive period, have not been thoroughly studied. In this study, we …
-
Targeting NMDA Receptors to Tune Corticothalamic Circuit Function
… ascending sensory signals, and disruption to the balance of excitation and inhibition (E/I) within CT circuitry leads to absence seizures, sleep disorders, and attention deficits. E/I balance may be restored by independently modulating excitatory CT input to the ventral posteromedial (VPM) …
-
Dynamical Systems Analysis of Neural Circuits with Applications to Physiological Processes
… input and intrinsic excitatory–inhibitory balance control the emergence of oscillatory activity in the circuit and shape the MePD output that acts downstream of the GnRH pulse generator. In contrast to earlier assumptions of constant MePD output, the model establishes the plausibility of …
-
The Role of Gamma Oscillations and Cortical Inhibition In The Development of Working Memory In Adolescence
… gamma-aminobutyric acid (GABA)-mediated cortical inhibition underlies these changes. I hypothesized that cortical gamma-band rhythms would become faster during adolescence in a manner that supports improved working memory capacity, and that the kinetics of cortical inhibition would also become …
-
The Neural Underpinnings of Obsessive-Compulsive Disorder: From Adolescence to Adulthood
… and habitual systems, driven by disrupted excitation-inhibition (E/I) balance within corticostriatal circuits. This thesis builds directly on previous work in adult OCD, particularly the findings of Biria et al. (2023), which demonstrated altered glutamate and GABA concentrations in …