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Showing 1 to 20 of 117 for “"Excipients"”.
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Role of Mechanical Stress, Excipients and Coprocessing On Tablet Mechanical Properties
The general objective of this work was to understand the role of compression speed and powder co-processing on tablet mechanical properties. In the first chapter, the effect of compression speed on compressibility, tabletability, and compactibility profiles of various materials was explored. The …
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Protection Mechanisms of Excipients on Lactate Dehydrogenase during Freeze-Thawing and Lyophilization
… the protective effects and mechanisms of excipients on a labile model protein, lactate dehydrogenase (LDH), during freeze-thawing and lyophilization. Cryoprotectants are excipients that protect labile molecules during freezing. Some investigators believe that preferential exclusion is the …
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Dissolution kinetics of model api in molten polymer excipients during batch processing
… thermal degradation of the polymer (and/or other excipients) and API are major concerns in the pharmaceutical HME process: researchers aim to dissolve the total loading of the API into the excipient within the short residence time with minimal API degradation. Therefore, the kinetics of the …
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The development of novel excipients for the stabilization of proteins against aggregation
… been successful, though the effects of common excipients are generally universal. The current approach toward stabilizing protein drugs against aggregation is by trial-and-error testing of different combinations of cosolutes (e.g. salts, sugars, surfactants, amino acids, etc.) using empirically …
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Protein stability: Impact of formulation excipients and manufacturing processes in protein-based pharmaceuticals
… In the formulation development, additional excipients were added to prevent moisture uptake due to the hygroscopic properties of the amino acids and to provide lyo- and cryo- protection for the protein molecule during freeze drying. Without further purification, BSA solutions prepared by …
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EVALUATION OF PHARMACEUTICAL AND COSMETIC USE OF EXCIPIENTS OBTAINED FROM CITRUS PROCESSING WASTE PRODUCTS
… formulation of SLNs and NLCs prepared with other excipients. Secondly, the peculiar composition of BLCs led to a characteristic lipid-shell structure which was able to accommodate large amounts of drug, avoiding drug leakage phenomena over time. Finally, the data also proved that BLCs can be used …
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Use of Aloe vera and Aloe marlothii materials as excipients in beads produced by extrusion–spheronization
… and Aloe marlothii leaf materials can be used as excipients in the production of beads prepared by extrusion spheronisation. A 2³ full factorial design was employed for optimisation and to explore the effects of the concentration of MCC, polyvinylpyrrolidone and aloe materials on the sphericity …
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Development of cocrystals of water insoluble active substances with inactive excipients by using hot melt extrusion
The major aim of the research reported herein was to develop and optimise hot melt extrusion (HME) as a robust technique for the cocrystallisation of poorly water soluble drugs and their coformers. Two pairs of cocrystals of a poorly water soluble drug, carbamazepine, with saccharin and …
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Development of a Kinetic Model to Investigate the Effect of Compositional Variation and a Processing Condition on the Solid-State Degradation of Gabapentin
… that physicochemical properties of the excipients and compaction pressure will accelerate the solid-state degradation of gabapentin, increasing the kinetic rate constant for lactam formation. To test the hypotheses, binary mixtures and compacts of gabapentin with different excipients …
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Insight into Nucleation Kinetics of Flufenamic Acid Cocrystal Formulation in Solution: Investigating the Role of Polymeric Excipients through Combined Experimental and Computational Approaches
… with a particular focus on the role of polymeric excipients. The impact of selected polymers, polyvinyl pyrrolidone (PVP), polyvinylpyrrolidone-vinyl acetate copolymer (PVP-VA), polyethylene glycol (PEG), and soluplus (SOL), on the nucleation and growth of cocrystals of FFA with theophylline …
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Evaluation of predictive computational modelling in biologic formulation development
… predictive computational model to screen for excipients that would decrease protein aggregation in solution and thus increase its stability and enable clinical effectiveness. Protein drug formulation currently relies heavily on empirical evidence from wet-lab experiments and personal …
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Further exploring the pharmaceutical applications of novel microwave-induced in situ amorphization
… indomethacin (IND, the model drug), dielectric excipients and polymeric carriers were prepared, microwaved and characterized to study the amorphization efficiency and the physical stability. The ability of dielectric excipients in facilitating microwave-induced in situ amorphization was assessed …
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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets
… drying were used to prepare the co-processed excipients with CA, plasticizer and inert excipient. The physical, flow and compaction properties of the co-processed excipients were evaluated. All the co-processed excipients prepared in this study all showed good flow characteristic. The spray …
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Solubility Enhancement via Melt Extrusion: Drug-polymer Solubility, Physicochemical Characterization and Quality by Design
… it is important to select appropriate excipients that will maintain the drug in its amorphous form for an extended period of time. Selection of appropriate excipients is critical during the development of stable amorphous solid dispersions. The solubility parameter concept has been …
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ACID-BASE REACTIONS IN DIFFERENT SOLID-STATE FORMS
… reactions might occur between APIs and ionizable excipients, which would induce deleterious form conversions or chemical degradation of the APIs during storage or manufacturing. Therefore, understanding the fundamentals of acid-base reactions is critical to design a robust formulation and to avoid …
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Study of SERS for the detection of drugs of abuse
… using Raman to identify what drugs and excipients might be present in oral fluid samples obtained from users. Overall, it is possible to identify the presence of phenethylamines and excipients in the seized tablets but not categorically distinguish between the phenethylamine …
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Preparation of novel modified-release dosage forms of diclofenac sodium and ibuprofen.
… the principle release-retarding agents. Various excipients - lactose, Encompress®, cellulose acetate phthalate (CAP), Veegum F® and Avicel PH101® - were added in different proportions to further modify drug release. The diclofenac sodium mini-matrices (4.5 mm in diameter) were produced by the …
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