Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Exchange protein activated by cAMP (Epac)"”.
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The Role of Interleukin-6 in the Regulation of Glucose Sensing in Hypothalamic GT1-7 Neurons
… in mounting the CRR. Detection of hypoglycaemia by specialised glucose-sensing neurons of the hypothalamus is critical for initiating the associated CRR. It is believed that defective CRRs are mediated by brain adaptations leading to impaired central glucose sensing, although the mechanisms by …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
The recent discovery of a new family of cAMP sensor proteins, exchange protein activated by cAMP (EPAC), ushered in a new era in cAMP signaling. EPAC is composed of two main isoforms, EPAC1 and EPAC2, whose roles in mediating cAMP effects in various cellular contexts remains relatively unclear, and …
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Host response of lung cells to virulent Bacillus anthracis
… macrophage (MØ) as the primary cell utilized by spores as a safe site for germination and transport to host lymphatics. This study was the first to report that, unlike their murine counterparts, human alveolar MØs mediate the killing of the majority of internalized virulent B. anthracis …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
… role in brain disease through binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 inhibits or stimulates ICAM-1 expression depending on the cell type and experimental conditions. …