Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Exchange protein activated by cAMP"”.
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The Role of Interleukin-6 in the Regulation of Glucose Sensing in Hypothalamic GT1-7 Neurons
… in mounting the CRR. Detection of hypoglycaemia by specialised glucose-sensing neurons of the hypothalamus is critical for initiating the associated CRR. It is believed that defective CRRs are mediated by brain adaptations leading to impaired central glucose sensing, although the mechanisms by …
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Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
… in response to the frictional force exerted by the flowing blood, fluid shear stress (FSS). The hemodynamics dictating this force determine, to a large extent, the likelihood that a given region of a blood vessel will develop atherosclerotic plaque. In linear arterial segments, VECs are …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
The recent discovery of a new family of cAMP sensor proteins, exchange protein activated by cAMP (EPAC), ushered in a new era in cAMP signaling. EPAC is composed of two main isoforms, EPAC1 and EPAC2, whose roles in mediating cAMP effects in various cellular contexts remains relatively unclear, and …
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Host response of lung cells to virulent Bacillus anthracis
… macrophage (MØ) as the primary cell utilized by spores as a safe site for germination and transport to host lymphatics. This study was the first to report that, unlike their murine counterparts, human alveolar MØs mediate the killing of the majority of internalized virulent B. anthracis …
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The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
… IL-6 to activate the oncogenic signalling protein STAT3, thus inhibition of STAT3 activation is a popular avenue of research to augment prostate cancer therapies. In this study, the endogenous anti-inflammatory molecule cAMP was investigated as a mechanism by which to inhibit IL-6-induced …
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Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines: IL-6 and leptin in endothelial cells
… of the prototypical second messenger cyclic-AMP (cAMP), notably with regard to endothelial function. Many studies have shown that cAMP can limit vascular permeability by enhancing barrier function and reducing pro-inflammatory effects of cytokines. Although the protective effects of cAMP elevation …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
… role in brain disease through binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 inhibits or stimulates ICAM-1 expression depending on the cell type and experimental conditions. …
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A Role For Epac1 and Epac2 In Nociceptor Hyperexcitability and Chronic Pain After Spinal Cord Injury
… options remain limited or non-existent. The cAMP sensor EPAC has previously been shown to play a key role in chronic inflammatory and neuropathic pain, though the contribution from each of its two main isoforms, EPAC1 and EPAC2, is unclear. Here I test the hypothesis that both EPAC1 and EPAC2 …