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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 61 for “"Exchange Factor"”.

  1. Characterization of a mammalian exchange factor, ralGDS

    Giddings, Barton William, 1963-Massachusetts Institute of Technology1994

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.

    mit Repository record

  2. The Arf GTPase exchange factor Sec7p interaction network:

    Gloor, YvonneTechnische Universität Dresden

    … screens before focusing on the role of Arf exchange factors. We report two new physical interactors of the late Golgi Arf-GEF Sec7p: the lipid kinase Pik1p and the cyclic nucleotide phosphodiesterase Cpd1p. In addition, our studies on the function of Sec7p revealed additional feature of this …

    qucosa-diss

  3. Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast

    Abrams, Jennifer Lynn2014

    … interact with up to three distinct nucleotide exchange factors (NEFs) homologous to human counterparts; Sse1/Sse2/HSP110, Fes1/HspBP1, and Snl1/Bag1. In an effort to understand the differential functional contributions of the cytosolic NEFs to protein homeostasis (“proteostasis”), I carried out …

    uthsc Repository record

  4. The Role of BiP Nucleotide Exchange Factor Sil1 in Immunoglobulin Biosynthesis

    Sanford, Tyler2016

    … genres of cochaperones, HSP40s, and nucleotide exchange factors (NEFs). HSP40s function in stimulating the hydrolysis of ATP, which causes a conformational change that induces tight binding of BiP to substrate, whereas, NEFs stimulate the escape of ADP that allows BiP to release substrate so …

    tenn-hsc Repository record

  5. Zyxin signaling: Protease-activated receptor-1 and Rho guanine nucleotide exchange factor p114.

    Jingyan. Han (7998782)2009

    … receptor-1 and Rho guanine nucleotide exchange factor p114.

    uic

  6. The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission

    Bungers, Simon2012

    … Austausch Faktor (englisch: guanly-nucleotide exchange factor, GEF) und wird in hohem Maße im Hippocampus exprimiert. Viele andere GEFs und auch GTPase aktivierende Proteine (GAPs), die Ras Proteine regulieren, wurden schon auf ihre neuronale Funktion hin untersucht. Im Gegensatz dazu wurde die …

    goettingen Repository record

  7. Invesitagating the role of the guanine nucleotide exchange factor P-Rex1 in cell invasion

    Lawn, Samuel OliverUniversity of Glasgow2008

    … cytoskeleton. P-Rex1, a Rac guanine nucleotide exchange factor (GEF), was previously identified in this lab in a transcriptional screen for mediators of cell invasion. A number of GEFs have been shown to regulate the invasive phenotype of tumours and cancer cell lines, leading to the hypothesis …

    glasgow Repository record

  8. The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42

    Wallenfang, Adam James2010

    … facilitated by the action of GTPase activating factors (GAPs) and Guanine Nucleotide Exchange Factors (GEFs). GAPs accelerate the intrinsic catalytic activity of the GTPase to physiologically relevant levels and lead to the rapid inactivation of a GTPase. GEFs conformationally eject bound GDP …

    utswmed Repository record

  9. Identification and characterization of genetic interactors of the Rho Guanine-nucleotide exchange factor Pebble in <em>Drosophila</em>

    Draga, Margarethe MariaUniversity of Dundee2010

    … C-terminal tail might regulate or enhance the exchange activity of Pbl for Rac. The localization and function of Pbl depends on the PH domain and the C-terminal tail of Pbl. Both domains have distinct roles during Pbl function in mesoderm cell migration.

    dundee Repository record

  10. Identification and molecular analysis of the role of guanine nucleotide exchange factor RIC-8 in mouse development and neural function

    Tõnissoo, Tambet2011

    tartu

  11. Étude du rôle de l'expression de RAB Guanine nucleotide Exchange Factor-1 (RABGEF1) au sein des cellules épithéliales intestinales dans la régulation de l'homéostasie et de l'inflammation intestinales

    El Abbas, SophieULiège - Université de Liège2019

    liege Repository record

  12. Characterization of Tuba, a novel Ena/VASP ligand, and function of Ena/VASP proteins in mouse development

    Kwiatkowski, Adam Vincent, 1974-Massachusetts Institute of Technology2005

    … in vivo. Tuba is a unique guanine nucleotide exchange factor (GEF) for Cdc42 that binds dynamin and a number of actin regulatory proteins in addition to Ena/VASP proteins. A knockout of EVL was made to determine the requirement for EVL in mouse development. Genetic analysis of EnaNASP function …

    mit Repository record

  13. The Src- and Abl- Dependent Regulation of Net1A In Breast Cancer

    Sprenger, Ashabari, <p><strong>0000-0002-1090-2118</strong></p>2022

    … gene 1 (Net1) is a RhoA guanine nucleotide exchange factor that promotes cancer cell motility and metastasis. Two isoforms of Net1 exist, Net1 and Net1A, both of which are which sequestered in the nucleus in quiescent cells to prevent aberrant RhoA activation. Many cell motility stimuli …

    uthsc Repository record

  14. An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11

    Timoney, Jennifer AnneUniversity College Cork2016

    … an effector for Rab11a and a Guanine nucleotide Exchange Factor (GEF) for Rab8a. Rabin8 participates in a conserved Rab activation cascade which is critical in the formation of primary cilia. Data presented in this thesis has shown that GRAB interacts with Rab3a, Rab8a, Rab11a and Rab11b in a …

    cork Repository record

  15. Signalling and function of the small Rho GTPase RhoJ in endothelial cells

    Leszczynska, KatarzynaUniversity of Birmingham2011

    … recycling. Vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF-2) and thrombin activated RhoJ in ECs. PAK-interacting exchange factor β (βPIX) and G protein-coupled receptor kinase-interacting target 1 (GIT1), which promote FA disassembly, were identified as …

    birmingham Repository record

  16. Targeting the Rho1 GTPase signalling pathway in <i>Aspergillus fumigatus</i>

    Wei, WenfanUniversity of Dundee2017

    … the upstream activation GEF (Guanine nucleotide exchange factor) proteins. Therefore, in this research I have identified a lead molecule that could be used to develop inhibitors against <i>Af</i>Rho1 and <i>Hs</i>RhoA by inhibiting the corresponding GEF proteins mediated nucleotide …

    dundee Repository record

  17. Biochemical and Structural Analysis of the Nucleoporin Nup214 and its Involvement in mRNA Export

    Napetschnig, Johanna

    … Finally, I speculate that Nup214 is the ATP-exchange factor for Ddx19, and propose the Ddx19 ATPase cycle as the terminal step in mRNA export.</p>

    rockefeller Repository record

  18. An Investigation into the Role of Arf6 in MCH-mediated Rearrangements in 3T3-L1 Preadipocytes

    Smich, Bohdan2020

    … that MCHR1 activates ARNO, a guanine nucleotide exchange factor that is required in the subsequent activation of ADP-ribosylation factor 6 (Arf6). These events in succession may result in destabilized actin in murine 3T3-L1 pre-adipocytes. A pharmaceutical inhibitor of Arf6, NAV-2729, as well as …

    brockport Repository record

  19. The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling

    Stevens, C.N.UCL (University College London)2009

    … to the IFNAR; the 95kDa guanosine nucleotide exchange factor, Vav, and the 76kDa adaptor protein Slp76. This proceeds in a similar manner to that observed at the TCR. Furthermore, the absence of either protein impairs IFNAR-induced ERK MAPK signalling. The similarities between TCR and IFNAR …

    ucl Repository record

  20. Mechanisms of Gradient Tracking During Yeast Mating

    Johnson, Jayme M.2012

    … between receptor-activated G&beta; and the exchange factor for the polarity regulator Cdc42. We found that artificially stabilizing patch wandering impaired accurate gradient tracking.</p><p>We suggest that ongoing polarized vesicle traffic causes patch wandering, which is locally reduced by …

    duke Repository record

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