Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 153 for “"Exacerbation"”.
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Exacerbation and glucocorticoid toxicity profile in patients receiving mepolizumab for severe eosinophilic asthma
… been shown to lead to a 50% reduction in exacerbation rate, when compared with placebo, and facilitates the weaning of maintenance oral corticosteroids (OCS) in patients with severe eosinophilic asthma. <br/><br/>This works seeks to address two questions that arise from treatment with this …
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Adapting An Evidence-Based Pediatric Acute Asthma Exacerbation Severity Assessment Tool For Pediatric Primary Care
… from evidence-based pediatric acute asthma exacerbation assessment tools, asthma scores, and the acute asthma prediction rule validated and utilized in the emergency department and to adapt these criteria for pediatric primary care.</p> <p>Method: Three stages of the project included: (1) …
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Does Exercise Prevent Exacerbation of Anxiety-Related Vulnerability Factors Following An Analogue Stressor: A Randomized Controlled Trial
The most common mental disorders are anxiety-related disorders (Andlin-Sobocki & Wittchen, 2005). The diathesis-stress model of psychopathology explains that stressors interact with vulnerability factors to influence the development of anxiety-related disorders (Monroe & Simmons, 1991); therefore, …
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Characterisation of exacerbations in non-CF Bronchiectasis to establish endpoints in measuring treatment efficacy
… productive of mucopurulent sputum and frequent exacerbations. We have aimed to validate clinical, biochemical and microbiological endpoints to aid planning of future interventional studies. We recruited fifty-eight subjects with bronchiectasis at the Lung Defence unit (Papworth Hospital, …
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FUNCTIONAL CHARACTERISATION, DISEASE BURDEN AND PREDICTORS OF MORTALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: PRELIMINARY RESULTS FROM THE ITALIAN COPD REGISTRY
… Patients with COPD are at increased risk of exacerbations, hospitalizations and mortality, but although over the years numerous severity classification systems have been proposed, they often revealed to be poorly associated with clinical outcomes. The degree of disease burden, the role of …
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Cytokines and aeroallergens in the pathogenesis of summer-pasture associated obstructive pulmonary disease: effects on endothelin production, neutrophil activation and chemotaxis
… disease of horses, is characterized by clinical exacerbation associated with exposure to pasture environment during the summer. Aeroallergens are believed to trigger exacerbation of SPAOPD, cytokines are likely associated with the anamnestic response to aeroallergens, and endothelin (ET)-1 is a …
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Ambient particulate matter as a trigger for acute exacerbations of asthma
… matter have been associated with acute exacerbations of asthma. The mechanism(s) by which non-allergic stimuli such as particulate pollutants trigger exacerbations of allergic asthma are unknown, but may involve injury to airway epithelial cells (AEC) via oxidative stress. Objective: To …
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Association of cardiovascular and musculoskeletal biomarkers with clinical outcomes in chronic obstructive pulmonary disease.
… weakness and plasma biomarkers for acute exacerbation of COPD, hospital admission and mortality, as there is currently no individual biomarker able to reliably identify or predict these common clinical outcomes. The aim of this research was to identify and evaluate the predictive value of …
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The Effects of Pregnancy on Systemic Lupus Erythematosus
… Controversy exists about the occurrence of exacerbations during pregnancy and the effect these exacerbations will have on the basic disease process. The purpose of this study was to investigate the effect pregnancy would have in precipitating exacerbation of disease activity. The …
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IMPACT OF SARS-COV-2 RESPIRATORY INFECTION ON CLINICAL OUTCOMES AND NEED FOR NON-INVASIVE VENTILATORY SUPPORT IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A SINGLE-CENTER, PROSPECTIVE, OBSERVATIONAL STUDY
… bacterial infections are the main cause of COPD exacerbations, accounting for 25% and 26% of cases respectively. To date no conclusive data are available on the risk of COPD exacerbations triggered by SARS-CoV-2. The present study was primarily aimed to identify the risk of acute respiratory …
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Assessing the role of temperature and air pollution in exacerbating childhood asthma in Cape Town, South Africa
… evidence on the role of air pollution in asthma exacerbation but limited research on the role of climate change and how the interaction between climate change and air pollution is affecting childhood asthma, specifically in low and middle-income countries (LMICs). Temperature changes can be used …
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Effort-Independent Asthma Severity Classification
… recordings from subjects with asthmatic exacerbation may be distinguished from their normal/baseline recordings with an AUROC of 0.92 (0.84 -- 1.00). Additionally, using data from an acute pediatric setting we show that recordings from subjects with severe asthmatic exacerbation may be …
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The Risk of Serious Respiratory-Related Events Following Immunization with the Quadrivalent Human Papillomavirus (qHPV) Vaccine: The Ontario Grade 8 HPV Vaccine Cohort Study
… increases the risk of incident asthma, asthma exacerbation, and anaphylaxis. Methods: A population-based retrospective cohort of grade 8 girls eligible for Ontario’s HPV immunization program between 2007 and 2011 was identified using the province’s administrative health and immunization …
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A quality improvement cycle for acute bronchospasm in primary health care: Mitchell's Plain Community Health Centre, Cape Town
… Community Health Care casualty were for an acute exacerbation of asthma and 7.8% of total deaths were from acute asthma. There was generally poor adherence to the national guidelines with respect to the management of an acute asthma exacerbation. Aim and Objectives: This study aimed to assess and …
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Risk, Vulnerability, and Hazards: The Industrial Canal and the Lower Ninth Ward
… to examine the implications of addressing the exacerbation of exposure to natural hazards within the traditional environmental justice framework. The Industrial Canal and Lower Ninth Ward were selected as the subjects of this case study because the canal has existed on the perimeter of the …
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Determining the impact of Heligmosomoides polygyrus infection on the development of colitis
… as measured by histology and flow cytometry. Exacerbation of DSS colitis is dependent on the dose of H.polygyrus but is independent of the phase of H.polygyrus infection, with both acute and chronic infections resulting in the same phenotype. Helminth exacerbated DSS colitis is characterised …
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The effect of smoking on the severity of mechanisms of acute exacerbations of COPD
… a prevalence of 10% in men and 8.5% in women. Exacerbations of COPD account for approximately 10% of all acute medical admissions. Projected prevalence figures suggest that by 2020 COPD will be the third leading cause of mortality worldwide thus imposing a significant burden on healthcare …
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