Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Ewing Sarcoma"”.
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Identification of EWS-FLI1 Regions Necessary for Ewing Sarcoma Proliferation
Ewing sarcoma is pediatric bone malignancy defined by a translocation between EWS and ETS family transcription factor. EWS-FLI1 (EF) is the most common translocation and codes for a novel transcription factor that combines the N-terminus of EWS, which contains LC domain comprised of tyrosine rich …
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The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation
… including neuroectodermal and bone tumours. Ewing sarcoma (ES) / primitive neuroectodermal tumour (PNET) shows varying degrees of neuroectodermal differentiation and is the second commonest bone malignancy in childhood. A recent study on ES cell lines using RT-PCR analysis and biological …
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Identifying CDK8/19 as a Novel Regulator of EWS-FLI1 Function in Ewing Sarcoma
Ewing sarcoma, a pediatric bone cancer, is characterized by the translocation of the Low Complexity (LC) domain from an RNA binding protein (EWSR1, FUS, or TAF15) with the DNA binding domain of an ETS transcription factor. The translocation EWS-FLI1 accounts for 90% of Ewing sarcoma tumors and a …
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Genomic Characterization of Adolescent and Young Adult Cancers: Investigation of Ewing Sarcoma Susceptibility and Chornobyl Thyroid Tumors
… features in two different AYA cancer types: Ewing Sarcoma (EwS) and papillary thyroid carcinoma (PTC). In the EwS study, we describe the interplay between a somatic driver, EWSR1- FLI1, and a highly polymorphic GGAA microsatellite in the 6p25.1 EwS GWAS susceptibility locus, employing third …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
… ganglioneuroblastoma, ganglioneuromas), Ewing s sarcoma/pPNET (EWS/pPNET), embryonal and alveolar rhabdomyosarcomas, lymphoblastic lymphoma and Wilms tumor, to assess the potential utility of these markers in the differential diagnosis of these tumors; iii) Ewing Sarcoma derived by …
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Improving cancer therapy strategies via cellular stress and immune modulation
… response (UPR). Preclinical studies in osteosarcoma (OS), chondrosarcoma (CS), and Ewing sarcoma (ES) demonstrated potent ErSO mediated cytotoxicity and anti-metastatic activity, significantly extending survival even in late stage, chemoresistant models. Mechanistic analyses revealed that …
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A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
… the role of frequent chromosome 8 (chr8) gain in Ewing sarcoma, a pediatric bone and soft tissue tumor that is mainly driven by the EWS-FLI1 fusion oncogene. Here, we specifically investigate the molecular mechanism of one chr8 gain-driver gene, RAD21, in mitigating EWS-FLI1-induced replication …
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Identification Of Neuroblastoma And Its Prognostic Markers Using Raman Spectroscopy
… tumors, including non-Hodgkin lymphoma, rhabdomyosarcoma, and Ewing sarcoma. One method of judging neuroblastoma aggressiveness uses tumor histology factors, including mitosis-karyorrhexis index, Schwannian stromal development, degree of differentiation, and patient age. Tumor aggressiveness can …
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Development of a High-Throughput 3D Tumor Model for Bone Sarcomas
… of a high-throughput 3D tumor model of bone sarcoma based on tissue-engineered polymeric scaffolds in combination with a flow perfusion bioreactor. First, we investigated the effects of flow perfusion on a 3D culture of Ewing sarcoma (ES) cells. We found that increasing levels of flow-derived …
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… cause of death for patients with pediatric osteosarcoma (OS). OS has a high degree of heterogeneity and genomic instability, making understanding the pathogenesis and drivers of metastasis of this disease challenging. In an effort to explain tumoral heterogeneity, the tumor initiating cell model …