Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Evolutionary Trace"”.
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Identification of A Conserved Cluster In The Rh Domain of Grk Critical For Activation By Gpcrs
… deterministic of protein function employing evolutionary trace (ET) methodology and crystal structures of GRK6. Focusing on a conserved cluster centered on helices 3, 9, and 10 in the RH domain, key residues of GRK5 and 6 were targeted for mutagenesis and functional assays. We found that a …
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Relating the structure of the HSV-1 UL25 DNA packaging protein to its function
… identified on the surface of the protein using evolutionary trace analysis (Lichtartge and Sowa, 2002). To examine the function of the protein in relation to its structure, site-directed mutations were engineered into the UL25 gene in a protein expression plasmid. A series of mutant proteins was …