Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"Evolutionary Conservation"”.
-
Evolutionary conservation and characterization of the metazoan amino acid response
… regulates key tissue protective signals. Using evolutionary conservation of this pathway in model organisms, I have identified GCN1 as the branch point that links the signal generation components of the AAR pathway to downstream therapeutic effects. I then used transcriptomic and protein …
-
Evolutionary conservation and characterization of the metazoan amino acid response
… regulates key tissue protective signals. Using evolutionary conservation of this pathway in model organisms, I have identified GCN1 as the branch point that links the signal generation components of the AAR pathway to downstream therapeutic effects. I then used transcriptomic and protein …
-
Evolutionary conservation of host responses to arbuscular mycorrhizal symbiosis in liverworts
… bridge this knowledge gap by investigating the evolutionary conservation of AMS molecular pathways in the liverwort Marchantia paleacea, with a combination of phylogenetic, comparative transcriptomic and reverse genetic approaches. The dynamic response of M. paleacea to colonization by the AM …
-
Evolutionary conservation of unistrand piRNA clusters and characterisation of the piRNA precursor export machinery in Drosophila
The PIWI-interacting RNA (piRNA) pathway prevents endogenous genomic parasites, transposable elements, from damaging the genetic material of animal gonadal cells. Specific regions in the genome, called piRNA clusters, are thought to define each species’ piRNA repertoire and therefore its capacity …
-
Patterns of Evolutionary Conservation and Divergence in the Short-Term Hyposalinity Stress Response of a Euryhaline Diatom, Skeletonema marinoi
… followed by adaptation and diversification over evolutionary time scales. To understand to what extent the diatom hypoosmotic stress response consists of conserved and variable elements, we used RNA sequencing during an 8 hour time series to characterize the short-term stress response to …
-
The Isolation and Partial Purification of DNA Polymerase-Beta from Soybean
… structure of polymerase-beta shows significant evolutionary conservation in both plant and animal species and given strong functional correlations among species, polymerase-beta performs a vital role in plants in the repair of newly synthesized DNA just as it does in animal systems.
-
Expression of Usherin in Human Tissues: Implications for Diagnostics and Pathology
… with the usherin distribution in the mouse. Conservation of usherin is also present at the nucleotide and amino acid level when comparing the mouse and human gene and protein sequences. Evolutionary conservation of usherin expression at the molecular level and in tissues unaffected in USH2A …
-
Generation of A L. Hesperus embryonic cDNA library for the isolation of genes involved in early pattern formation
… to regulate embryogenesis. Because of the high evolutionary conservation of Hox and Pax proteins, I hypothesize that arachnids also use this system to organize their body pattern. To enable studies of the Westem black widow spider, Latrodectus hesperus, an embryonic eDNA library and a fixation …
-
ModuleFinder : a computational model for the identification of Cis regulatory modules
… (2) heterotypic site clustering; and (3) evolutionary conservation across multiple genomes. Importantly, ModuleFinder obtains all parameters needed to appropriately weight the relative contributions of these sequence features directly from the input sequences and TFBS motifs, and does not …
-
LEVERAGING EVOLUTION TO UNDERSTAND GENETIC LOAD IN CASSAVA (MANIHOT ESCULENTA)
… other publicly available genome data, I analyzed evolutionary conservation across 53 species. By looking at selection signatures in cassava through evolutionary conservation, I discovered genes responsible for effective sexual reproduction to have an abundance of functional mutation in cassava …
-
Spatial Expression Patterns of theSnmp Gene Family In Drosophila Melanogaster
… and Lepidoptera (Nicholls and Vogt, 2008). This evolutionary conservation provides intriguing, if indirect, evidence for their important biological function. Studies in D. melanogaster have shown that SNMP1 expresses in olfactory neurons of trichoid (pheromone) sensilla and is required to induce …
-
Computational and experimental analysis of plant microRNAs
… to the monocot Oryza sativa (rice), implying evolutionary conservation based on function at the nucleotide level. The majority of predicted miRNA targets encode for transcription factors and other proteins with known or inferred roles in developmental patterning, implying that the miRNAs …
-
The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
… findings resolve longstanding questions into the evolutionary conservation of Ugdh function and provide new mechanistic insights into the initiation of left-right asymmetry.
-
Integrated Machine Learning and Bioinformatics Approaches for Prediction of Cancer-Driving Gene Mutations
… data. By analyzing pathogenicity prediction and conservation scores, we have shown that evolutionary conservation scores play a pivotal role in the classification of cancer drivers and were the most informative features in the driver mutation classification. Through extensive comparative analysis …
-
A computational framework for the identification, cataloging, and classification of evolutionary conserved genomic DNA
… proteins. Subsets of these ecores also exhibit conservation that extends across several species. These genomic regions have managed to survive millions of years of evolution despite the fact that they do not appear to directly encode for proteins. The survival of these regions compels us to …
-
Inhibition of horseradish peroxidase activity by specific antibody
… horseradish isoenzymes. These results support an evolutionary conservation of acidic isoenzymes and suggest that each isoenzyme group catalyzes specialized plant functions.
-
Understanding the role of dMob4 in postembryonic Neural Stem Cell mitotic reactivation
… pathways to promote NB reactivation. Given the evolutionary conservation of the molecules investigated, my findings may also be relevant to mammalian NSCs and other stem cells.
-
Somatic Stem Cell Populations and Studies on the Functional Role and Regulation of ABCG2
… To assess the regulation of Abcg2 I examined evolutionary conservation between the upstream regions of mouse and human Abcg2. Conserved regions were identified up to 11kb upstream of the mouse gene. In these regions, putative binding sites were discovered for transcription factors that are …
-
Evolutionary and conservation genetics of the Seychelles warbler (Acrocephalus sechellensis)
In this thesis, I investigated how evolutionary forces and conservation action interact to shape neutral and adaptive genetic variation within and among populations. To accomplish this, I studied an island species, the Seychelles warbler (Acrocephalus sechellensis), with microsatellite markers and …
-
The Role of GDF-3 in Patterning the Early Embryo
… tissue in frog embryos, thus highlighting the evolutionary conservation of mechanisms for neural formation. In mammalian embryonic stem cells, we found that GDF-3 opposes BMPs to regulate the balance of stemness and differentiation. These findings reveal the importance of negative, inhibitory …
Page 1 of 3