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Showing 1 to 11 of 11 for “"Evolution of proteins"”.
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Exploring the function and evolution of proteins using domain families
Proteins are frequently composed of multiple domains which fold independently. These are often evolutionarily distinct units which can be adapted and reused in other proteins. The classification of protein domains into evolutionary families facilitates the study of their evolution and function. In …
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CRISPR-based approach enables targeted random nucleotide diversification in mammalian cells
In vivo directed evolution opens the possibility to introduce genetic variation through targeted nucleotide diversification, leading to the discovery of new protein phenotypes that had been difficult to generate via rational mutagenesis. Tools for in vivo directed evolution have been mainly …
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Learning hierarchical motif embeddings for protein engineering
… an integrated machine learning framework for the evolutionary analysis, search and design of proteins, based on a hierarchical decomposition of proteins into a set of functional motif embeddings. We introduce, CoMET - Convolutional Motif Embeddings Tool, a machine learning framework that allows …
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Investigation Into Protein Folding and Misfolding
<p>Proteins are the fundamental building blocks of all living organisms. They are critical in the proper function of virtually all cellular processes and without them biological life would be impossible. Since their discovery, understanding the transition of DNA to functional protein has been …
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Analysis of Synaptotagmin-SNARE Complex Interactions by One-Dimensional NMR Spectroscopy
The mechanism of calcium-triggered neurotransmitter release is mediated by numerous proteins at the neuronal synapse. The SNARE proteins form a complex that mediates fusion between the synaptic vesicle and plasma membrane. The protein synaptotagmin-1 is the major sensor for the calcium …
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Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
With the advent of sophisticated genetic, biophysical and in silico technology an enormous amount of information is being generated regarding the structural, biochemical and physiological aspects of proteins. Tertiary protein structural domains are assumed to be features of proteins whose …
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The chemistry and evolution of enzyme function: isomerases as a case study
The study of the evolution of proteins has been traditionally undertaken from a sequence and structural point of view. However any attempt to understand how protein function changes during evolution benefits from consistent definitions of function and robust approaches to quantitatively compare …
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Molecular evolution of beta (â) keratins in three bird species and divergence time estimates for the avian â-keratin subfamilies
<p>The origin and evolution of feathers has fascinated the general public and researchers for many years. Interest in the evolution of feathers is frequently fueled by discoveries of feathered dinosaurs, such as the recently discovered Anchiornis huxleyi, which displays pennaceous feathers on all …
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MOLECULAR CHARACTERIZATION OF PROTEINS IN FOOD MATRICES: HOW THEIR STRUCTURE EVOLVE FROM RAW MATERIALS TO FINISHED PRODUCTS
Proteins have a fundamental importance for their peculiar chemical characteristic, implication in metabolism and structure for all living organisms. In food systems, proteins provide both nutritional and non-nutritional functionalities and, with other macromolecules, contribute in define the …
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Engineering genetic isolation in Escherichia coli and developing synthetic genomics tools to efficiently assemble megabase-scale genomes
… reaction (PCR) enable the specific amplification of chosen DNA sequence and synthetic genes are critical for the design and directed evolution of proteins. The synthesis of entire genomes empowers researchers to manipulate fundamental properties of organisms. Most notably the synthesis of the …
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DNA catalysts as phosphatases and as phosphoserine lyases
Proteins and RNA are the only known biopolymers that have catalytic roles in nature, whereas DNA is primarily considered to store and transfer genetic information. However, artificial single-stranded DNA has been identified by in vitro selection to catalyze several chemical reactions and several of …