Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Evolution of antibiotic resistance"”.
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Cooperative behaviors in the evolution of antibiotic resistance
Through a combination of experiments and modeling, I explored how inactivation of antibiotics by antibiotic-resistant bacteria affects the evolution of antibiotic resistance in two simple microbial communities. First, I examined the interaction between a resistant strain and a sensitive strain of …
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The role of cooperation and dispersal in the evolution of antibiotic resistance
Understanding mechanisms of evolution under in real biological systems is a fundamental problem. Natural selection is one of the mechanisms that drive evolution. Due to the natural selection, phenotypes with higher fitness than the rest of the population increase in frequency and eventually …
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Investigating the role of nonantibiotic chemical contaminants in the evolution of antibiotic resistance
Antibiotic resistance, the ability of bacteria to resist the effects of antibiotic drugs, has now become a global threat to public health. Every year around 700,000 people die due to the antibiotic-resistant bacterial infections, and this number is even predicted to reach as many as 10 million by …
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Collateral sensitivity and the evolution of drug resistance in Escherichia coli
… designing new therapies that could reduce rates of evolution of antibiotic resistance in pathogens. To explore this idea, I tested the key assumption that collateral sensitivity should reduce the frequency of mutation to resistance. Ceftazidime resistant strains showed susceptibility to …
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Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
The continuing evolution of antibiotic resistance strains of Neisseria gonorrhoeae coupled with the paucity of new antimicrobial agents makes the treatment of gonococcal infections challenging. A major cause of resistance is the expression of a multidrug efflux pump termed MtrCDE, which exports a …
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A Study of Antibiotic Resistance Plasmids in Fresh Produce and In Wastewater Environments Using Functional Approaches, Comparative Genomics and Abundance Analysis
Studies have shown that a major reservoir of clinically relevant antibiotic resistance genes (ARGs) is found in non-pathogenic environmental bacteria. Ciprofloxacin, meropenem and erythromycin are important clinical antibiotics due to their broad applications in the treatment of Gram-positive and …
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Antibiotic Tolerance and Heteroresistance: Associated Fitness Costs and Potential in Evading Antibiotic Killing
… it is frequently an asymptomatic colonizer of the human nasopharynx, S. pneumoniae is a major cause of morbidity and mortality in the immune compromised population, young children, and the elderly. Up until the 1970s, S. pneumoniae was susceptible to almost all antibiotics. Since then, this …
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An Economic Analysis of Evolving Health Hazards
Health hazards (e.g., West Nile virus and antibiotic resistance) by their nature are detrimental to the health of mankind and are a vexing problem for society. Health authorities awareness of the rising health care costs associated with these health hazards highlights the need to undertake research …
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Requirements and strategies for winning the battle against antibiotic resistance by antisense technology
… and conditions for efficiency and specificity of antisense molecules. For specific therapy, an antibacterial RNA must be able to distinguish between its designed targets and its off-targets. This distinction is reflected in the binding energy calculations. The major component of efficiency and …