Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Evolution, Molecular"”.
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Proton-coupled electron transfer in molecular and material catalysis
… and photo-excited reactions occurring in molecular, material, and biological systems. In this thesis, the role of PCET in hydrogen evolution molecular electrocatalysts, and iron-doped nickel-oxyhydroxide thin films used for oxygen evolution reaction, are explored by means of quantum …
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Molecular Systematics & Evolution of the CTENOSAURA HEMILOPHA Complex (SQUAMATA: IGUANIDAE)
<p>Molecular variation within <em>Ctenosaura hemilopha</em> and among other <em>Ctenosaura</em> species are used to identify species boundaries, assess suitable systematic characters, identify evolutionary patterns within <em>C. hemilopha</em> mitochondrial DNA sequences and reconstruct species and …
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Development of a thermometric sensor for fructosyl valine and fructose using molecularly imprinted polymers as a recognition element
… by nature to produce biomimetic materials with molecular recognition properties by design rather than evolution. Molecular imprinting is one way to prepare such materials. Such smart materials with new functionalities are at the forefront of the development of a relevant number of ongoing and …
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Hierarchy of Interactions in Protein Evolution
… (SCA) - one approach for studying the co-evolution of amino acid positions in homologous sequences - provides a model for this pattern that is distinct from spatial proximity in tertiary structure, positional conservation, or even other forms of co-evolution. Here, we use an extension of …
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Evolution of Pharyngeal Feeding Behaviors in Free-Living Soil Nematodes
The file named "ChiangJian-Tzyh.pdf" is the primary dissertation file. All other files ("*.mpg") are supplemental files and may be viewed individually.
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A Global Experimental Analysis of Protein Function: A Case Study in the PDZ Domain
… within a protein that displays significant co-evolution, termed protein sectors. Limited mutagenesis studies have shown sectors to be networks of higher-order interaction crucial for protein function; however, a theory of such global scope requires validation with a global experiment. Here, we …
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Multi-Scale Structure and Dynamics of Visual Signaling in Drosophila Photoreceptor Cells
… have many distinct features, particularly due to evolution. In this work, I used Drosophila phototransduction, a well-studied sensory system renowned for its high performance, to search for evolutionary design principles. I focused on three levels of structure in the system: compartmentalization …
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Low-Density Lipoprotein Receptors in Signaling Modulation and Development
… control the cellular proliferation at several molecular steps, and allow for proper organ formation by moderating and integrating cellular signaling pathways. / The use of knockin mutant mice has, for the first time, implicated the extracellular domains of LRP1b and LRP4 in signaling modulation …
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Toward Structural and Functional Predictions from Biological Sequences
… In the primary sequence level, I analyzed the evolutionary information encoded in protein families and predicted the function (and active sites) of the proteins. To aid my sequence analysis, I developed a set of computational methodologies and deployed them as public web-servers. In the protein …
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Distinct Functional Phases in Proteins: A Test by Large-Scale Protein Design
Note: The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access only.
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Molecular Underpinnings of Human Brain Evolution and Cognition at Cellular Resolution
… publication as a chapter in the book titled "The evolutionary roots of human brain diseases". This chapter is an edited version of the author's own original writing with additional edits by the author's thesis supervisor and from feedback from the editors of the book. The citation to the book is …
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Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
… This interaction creates significant host-driven evolutionary pressure, as many viruses have evolved mechanisms to evade IFIT1 antiviral function. However, less is known about the virus-driven pressures that have shaped the antiviral activity of mammalian IFIT1 genes. Here, I used evolutionary …
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In vitro evolution of ribozymes for self-synthesis
[Restricted]
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The Evolution of the Viral RNA Sensor OAS1 in Old World Monkeys and Cetartiodactyls
… of OAS1 variation indicates sites of accelerated evolution at the host-virus interface and at sites of possible viral antagonism, both signifying a history of virus-driven evolution. Finally, I have analyzed the cetartiodactyl OAS1 gene family which includes two, and in some lineages, three copies …
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Elucidating Mechanisms of Biofluorescence and Bioluminescence in Marine Organisms
… will look at separate proteins to uncover their molecular interactions that lead to light generation. We combine transcriptomics, phylogenetics, and biochemical assays to unravel these mysteries. We have studied fluorescent fatty acid binding proteins to discover which residues are important for …
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Interrelationships Among Monorchiid Trematodes with Special Emphasis on Some Northwestern Atlantic Genera
… with other oceans, recent morphological or molecular taxonomic work conducted on monorchiid species from the northwestern Atlantic Ocean has been sparse (Manter, 1931; Overstreet, 1969; Andres et al., 2018; Wee et al., 2018, 2019, 2020). Therefore, the present work investigated the …
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