Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Eukaryotic Initiation Factor-4E"”.
-
The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… of the mRNA cap-binding phosphoprotein, eukaryotic initiation factor 4E (eIF4E) is considered to be both rate and process limiting. We describe for the first time, the biological role of eIF4E (new biology) in metastatic osteosarcoma. We employed a comparative approach to study the …
-
Role of Ribavirin, an Anti-Viral Agent, In Eukaryotic Initiation Factor 4e (Eif4e) Subcellular Localization and Function
Expression of eukaryotic initiation factor 4E (eIF4E) is necessary for active cellular growth and catalysis of the rate-limiting step in cap-dependent protein synthesis3-5. Studies in the past decade have shown that eIF4E contributes to malignancy by selectively facilitating the translation of a …
-
Point mutational examination of eukaryotic initiation factor 4E (eIF4E), inclusion bodies analysis, and Barley Yellow Dwarf Virus (BYDV) exonuclease resistant RNA structure mapping and prediction
<p>Eukaryotic initiation factor 4E (eIF4E) binds the 5’m7GTP cap structure of mRNA in order to facilitate effective translation. Recessive eIF4E alleles harboring naturally occurring point mutations have been associated with resistance to viral infection, particularly in members of the genus …
-
Role of 4E-BP2 in neuronal translation
… synaptic plasticity, learning and memory. 4E-BP2 (Eif4ebp2, Eukaryotic Initiation Factor 4E-Binding Protein 2) is the predominantly expressed 4E-BP in the mammalian brain and represses cap-dependent translation initiation, by binding to eIF4E (Eif4e, eukaryotic Initiation Factor 4E). As a …
-
The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… <p>Prostate cancer cells overexpress eIF4E (eukaryotic initiation factor 4E) the rate-limiting protein that mediates cap-dependent translation by way of mTOR signaling. Immortalized Chinese hamster ovary (CHO) control cells (pMV7) and CHO cells with forced eIF4E-overexpression (rb4E) were …
-
Biochemical purification and functional characterization of the She RNP complex from S. cerevisiae
… In addition to the She proteins, accessory factors such as Loc1p or Khd1p have been suggested to function in ASH1 mRNA localization though they have not been identified in the genetic screen. Thus, in order to allow a detailed characterization of the ASH1-She RNP ('ribo-nucleoprotein') …
-
Mechanisms of selective translational control under short-term high light stress
… to drive the capacity of the translational initiation process. As all three mutations lead to a decrease of polysome-associated transcripts, chloroplast signals presumably set the first, yet possibly unspecific early layer in the journey to a tailored translatome upon high light stress. More …