Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Ethinylestradiol"”.
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Entwicklung, Optimierung und Validierung eines Immunoassays zur sensitiven Detektion des endokrinen Disruptors 17alpha-Ethinylestradiol
… beschäftigt sich mit der Analytik von 17alpha-Ethinylestradiol (EE2) in der aquatischen Umwelt. Der Schwerpunkt der Untersuchungen lag dabei in der Entwicklung und Optimierung von Enyzm-Immunoassays (ELISAs) zur direkten Bestimmung des Analyten im Konzentrationsbereich von 1 - 10 Nanogramm pro …
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Examining swim bladder inflation failure as a toxicological endpoint in Japanese medaka (Oryzias latipes)
… embryonic exposure to the pharmaceuticals 17α-ethinylestradiol, levonorgestrel, and diclofenac, impaired swim bladder inflation of Japanese medaka (Oryzias latipes). After exposure to individual compounds, mixture exposures to no-observed-effect concentrations of these compounds were conducted. …
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Regulation des renalen Natrium-abhängigen Gallensäuren-Transporters (ASBT) durch Sexualhormone und Glukokortikoide
… uptake. In contrast treatment of male rats with ethinylestradiol at a dose of 50 µg/kg body weight lead to a highly significant inhibition of 61.6 +/- 13.4% of the taurocholate accumulation ratio (p< 0.001). Neither surgical ovariectomy nor chemical castration with the GnRH- analog busereline (24 …
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Elimination organischer Spurenstoffe aus kommunalem Abwasser
… hormone 17b-estradiol and synthetic steroid 17a-ethinylestradiol were appointed as model compounds. The criteria of choice were different biological degradation and volatilisation rates, as well as different affinity to sewage sludge. The behaviour of the model trace pollutants during the …
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Multimethode zur Bestimmung von endokrin wirksamen Substanzen in Wasser
… entnommenen Konzentrationen an Estradiol, Ethinylestradiol, Nonylphenol, Phthalaten, Bisphenol A und DDT in den Oberflächengewässern sind jedoch stellenweise in der Lage, endokrine Effekte in Fischen und anderen aquatischen Organismen zu bewirken. Zusätzlich wurden Literaturdaten von …
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Entwicklung und Anwendung chemisch-analytischer Verfahren zur Bestimmung endokrin wirksamer Substanzen
… Estrone, 17beta-Estradiol, Estriol and 17alpha-Ethinylestradiol was selected. These substances possess a high environmental relevance. They will either manufacture in large quantities industrially or by biochemical degradation during the waste water treatment process or they are eliminated by …
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Kombinierte Freiland- und Laboruntersuchungen zur Wirkung endokriner Schadstoffe auf Fische
… bekannter hormonaktiver Referenzchemikalien (Ethinylestradiol, EE2; Methyltestosteron, MT) etabliert wurde. Abschließend wurde das Fischtestsystem hinsichtlich seiner Empfindlichkeit bei Freilandversuchen untersucht. Nach der Optimierung der In vitro-Biotests im Bereich der Umweltüberwachung, …
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Ökotoxikologische Untersuchungen zur Wirksamkeit endokrin aktiver Substanzen auf Fische
… nach Belastung mit Nonylphenol (NP)bzw. 17a-Ethinylestradiol (EE2) mit ei-nem alters- und dosisabhängigen Anstieg des PVG. Eine Exposition juveniler Karpfen und adulte männliche Regenbogenforellen ergab für NP- und EE2-haltige Klärabwässer einen deutlich schwächeren Anstieg des PVG als nach …
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The impact of restricted ration and chemical stressors on Rainbow trout (Oncorhynchus mykiss) and American flagfish (Jordanella floridae)
… concentrations of ibuprofen, naproxen, and 17 α- ethinylestradiol (EE2) alone and in mixture on both reproduction and subsequent sensitivity to offspring. Both a short-term reproduction test, and multi-generational study were used to assess a variety of endpoints. The partial life-cycle study …
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Differentielle Regulation organischer Anionentransporter der Oatp-Familie bei Ethinylöstradiol-induzierter Cholestase der Ratte
… were analyzed after 0.5, 1,3 and 5 days of ethinylestradiol treatment (5mg/kg) in rats. Regulation in mRNA and Protein levels were determined by northern and westernblotting. Binding activities of Oatp2 and Ntcp transactivators were assessed by electrophoretic mobility shift assays. As …
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Chemical mixtures and interactions with detoxification mechanisms and biomarker responses in fish
… receptor (AhR), and the synthetic estrogen 17α-ethinylestradiol, which activates the estrogen receptor (ER). The antagonistic mixture effect is caused by an inhibiting AhR-ER cross-talk. A cross-talk between the AhR and the pregnane-X-receptor (PXR) was also suggested in livers of the …
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Efficiency of soil aquifer treatment in the removal of wastewater contaminants and endocrine disruptors. A study on the removal of triclocarban and estrogens and the effect of chemical oxygen demand and hydraulic loading rates on the reduction of organics and nutrients in the unsaturated and saturated zones of the aquifer.
… (TCC), estrone (E1), 17¿-estradiol (E2) and 17¿- ethinylestradiol (EE2). SAT was simulated in the laboratory using a series of soil columns under saturated and unsaturated conditions. Investigation of the removal of Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD), Dissolved Organic …
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Elucidating Factors that Impact the Removal of Organic Microconstituents by Ammonia Oxidizing and Heterotrophic Bacteria
… microconstituents, carbamazepine (CBZ), 17alpha-ethinylestradiol (EE2), iopromide (IOP), and trimethoprim (TMP), during biological suspended culture treatment. Specifically, the role that various ecological members of biological treatment systems play in biotransforming these compounds was …
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The Influence of Estrogen Signaling on Male Reproduction in Medaka (Oryzias latipes)
… effects of a general estrogen receptor agonist, ethinylestradiol (EE2), and those of a G-protein estrogen receptor (GPER) specific agonist, G-1. This was assessed through breeding experiments, histological assessment of testicular morphology and microarray assessment of testicular gene expression …
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Fate and Transport of Endocrine Disrupting Compounds during Wastewater Treatment: The Role of Colloidal and Particulate Material
… for pyrene, 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) by fluorescence quenching. The MLSS-derived colloidal organic carbon (COC) sorption coefficient (Kcoc) for pyrene ranged from (< 1 to 80) L/kgcoc, indicating a similar affinity for pyrene compared to natural organic matter. …
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Assessing Brook Stickleback (Culaea inconstans) as a bioindicator for endocrine disrupting compounds in aquatic environments
… were then exposed to two model compounds, 17α-ethinylestradiol (EE2) and 17α-methyltestosterone (MT), at 1, 10 and 100 ng/L for 21 days (sampled at 7 and 21 days) via static-renewal to determine the responsiveness of these transcripts to exogenous hormones. The effect of hormone exposure on …
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New horizons of aliphatic C—H amination and hydroxylation reactions with manganese catalysis
… 2º benzylic/remote 2º C—H hydroxylations on an ethinylestradiol derivative where other oxidant only oxidize the doubly activated tertiary benzylic site. Mn(CF3-PDP) was also demonstrated to potentially serve as a general approach to rapidly access and identify drug metabolites (piragliatin) from …
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Development and Scale-up Production of a Novel Fibrous Catalyst and Application for Removal of Endocrine Disrupting Compounds
… was also very efficient in the removal of 17β-ethinylestradiol (EE2) using the same mesh to liquor ratio and [H2O2] as for E2, however the optimal pH for EE2 was pH 3. Under these conditions the removal was over 90% in 50 minutes. The removal of estrogenic compounds, pharmaceuticals, …
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Cytostatics in the aquatic environment : analysis, occurrence, and possibilities for removal
… hydrophobic substances, bisphenol A and 17-alpha-ethinylestradiol, produced with the identical experimental conditions and matrix. A dose of 30 mg.L-1 of Norit SAE Super that resulted in removal of the two hydrophobic control compounds below 1% was found to remove 30 and 65% of 5-fluorouracil and …
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