Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Ethanol Exposure"”.
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Neuroprotectant Properties of Neurosteroids During Neonatal Ethanol Exposure
<p>Neonatal ethanol exposure significantly affected development of medial prefrontal cortex pyramidal neurons by decreasing apical dendritic length and intersections. Neurosteroid treatment affected neuronal measurements in a sex-dependent manner, with neurosteroids having minimal to no effect on …
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Alterations In The Mouse Striatum Following Acute And Repeated Ethanol Exposure
… as a risk factor due to its involvement in ethanol consumption and addiction evidenced in a vast number of studies using both human and animal models. The goal of this study was primarily to understand how low endogenous BDNF levels could lead a person to be more susceptible to alcohol …
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Chronic prenatal ethanol exposure produces neurobehavioural and metabolic dysfunction in guinea pig offspring
Maternal ethanol consumption during pregnancy can produce teratogenic outcomes in offspring, which are collectively termed Fetal Alcohol Spectrum Disorder (FASD). Central nervous system (CNS) dysfunction is a debilitating and permanent manifestation of FASD. Recent studies indicate that chronic …
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Role of Rostromedial Tegmental Nucleus Afferents in Symptoms of Withdrawal from Chronic Ethanol Exposure
… emerged early after the cessation of ethanol exposure and persisted into protracted withdrawal. cFos expression, a marker of recent neuronal activity, was significantly increased in both the RMTg and RMTg-projecting lateral habenula (LHb) neurons during acute withdrawal. In vivo …
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THE EFFECTS OF SOCIAL STRESS AND PRIOR ETHANOL EXPOSURE ON DOPAMINE IN THE RAT BRAIN
… at a disproportionate rate. Stress and ethanol are two factors that can influence neurobiology and neurotransmitter signaling independently and have interacting effects. Their actions on the mesolimbic and nigrostriatal dopaminergic pathways of the central nervous system have been the …
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The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour
… and behavioural deficits observed after exposure to alcohol in utero, is a major public health issue specifically in South Africa. South Africa is thought to have the highest prevalence of FASD in the world. FASD presents as a variety of learning and memory deficits as well as …
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The effects of chronic intermittent ethanol exposure on fear conditioning in rats: an investigation of the comorbidity of PTSD and AUD
… we tested the effect of chronic intermittent ethanol (CIE), a model of alcohol dependence, on fear conditioning, a model of fear learning that engages circuits that are dysregulated in PTSD, in male Long Evans rats. We further expanded this research by looking at the effects of this exposure …
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Effects of Genetics and Sex on Hippocampal Gene Expression and Adolescent Behaviors Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mice
… our lab identified differential vulnerability to ethanol-induced call death in the hippocampus using fourteen BXD strains and the two parental strains. The goal of the present study was to examine the effect of genetics and sex on differential gene expression changes and behavioral responses in …
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Ethanol exposure during synaptogenesis in a mouse model of fetal alcohol spectrum disorders: acute and long-term effects on gene expression and behaviour
… phenotypes include alcohol dosage, timing of exposure, and pattern of maternal alcohol consumption; however, the biological processes that are vulnerable to ethanol at any given neurodevelopmental stage are unclear, as is how their disruption results in the emergence of specific pathological …
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The effects of chronic intermittent ethanol exposure on withdrawal related behaviors, dopamine terminal function and kappa opioid system sensitivity in the nucleus accumbens core
… and abstinence is often followed by relapse to ethanol drinking occurs in response to the withdrawal symptoms of the drug. However, the neurobiological underpinnings of this disorder are not well understood. Previous work has shown that chronic ethanol exposure and withdrawal downregulates …
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Chronic intermittent ethanol treatment yields persistent increases in anxiety and receptor subunit changes in adolescent and adult rats.
… are involved in the behavioral effects of ethanol; however, the age-dependent molecular mechanisms associated with the effects of chronic ethanol have yet to be fully elucidated. Adolescence is marked by unique sensitivity to certain effects of ethanol, including distinct consumption …
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
… genetic and environmental factors. Prenatal ethanol exposure results in the highest number of preventable birth defects in the United States. Prenatal ethanol exposure interacts with another well-established teratogen: prenatal hyperthermia. Additionally, each of these teratogens interacts …
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Quantitative Proteomic Methodology Use and Development to Characterize Ethanol Modulation of Microglial Function
… Microglial activation due to chronic ethanol exposure has been implicated in neuroinflammation. We use mass spectrometric metabolic labeling techniques to explore and quantify the microglial proteome in immortalized cell lines and in vivo enriched microglia. Our proteomic profiling and …
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Alterations in the Hippocampal Epigenome as a Result of Alcohol Exposure During the Perinatal Period of Development in Rats
… and, while many of the teratogenic effects of ethanol have been described, a mechanism through which alcohol causes these effects remains to be found. This study tested the hypothesis that developmental ethanol exposure alters the hippocampal epigenome in juvenile rats in a sex-specific manner. …
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Potential roles for Elf3 in fetal alcohol spectrum disorder and development
… disorder is a disease caused by prenatal alcohol exposure. It is characterized by craniofacial abnormalities, growth retardation, central nervous system defects, learning disabilities and a variety of other minor defects. Even though it affects 2-5% of individuals born every year, very little is …
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Schmidtea mediterranea planaris as a novel animal model for investigating the dynamics of nervous system development in fetal alcohol spectrum disorder
… disease that is caused by excess in utero exposure to ethanol. The importance of timing and dosage of ethanol has been elucidated by previous investigations conducted with humans, rodents, and other model organisms, but challenges associated with determining functional deficiencies have …
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Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
<p>Ethanol is a common factor in traumatic injury, including burn injury. Previous studies from our laboratory indicate that ethanol increases both pulmonary and gastrointestinal inflammation as well as susceptibility to infection in burn-injured mice; however, the mechanisms of these responses are …
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The effect of acute alcohol exposure on hepatic oxidative stress and function: prevention by micronutrients
… In the present investigation the effect of acute ethanol administration on hepatic oxidative damage and apoptosis was examined using both an in vivo and in vitro approach; the effect of micronutrient supplementation prior and during ethanol exposure was also studied. The following studies were …
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Biochemical changes in animal models of fetal alcohol spectrum disorder
… (Roozen, 2016). FASD is caused by maternal ethanol intake during pregnancy. However, recommendations of the amounts of alcohol safe to drink during pregnancy are not established. Further, we lack a comprehensive understanding of the biochemical pathways modified in prenatal ethanol exposure. …
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