Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"EthR"”.
-
Fragment-based approaches to targeting EthR from mycobacterium tuberculosis
… the enzyme EthA, which is in turn regulated by EthR. The disruption of the action of EthR could lead to novel therapeutics which could enhance the efficacy of ethionamide, and raise it to a first-line treatment. The work reported in this thesis examines the elaboration of three chemical …
-
Investigation of mass spectrometry approaches for aiding fragment-based drug discovery
… native MS was used to study the structure of the EthR-DNA complex, a tuberculosis target, and to screen fragments against a protein-DNA interaction for the first time. In Chapter 4, native MS and IM-MS were used to study the structure and interactions of the antibacterial target CoaB and its …
-
Review of Damage Control Laparotomy (DCL) outcomes in a Major Urban Trauma Center
… were retrieved from the prospectively recorded eTHR data base. Data retrieved were basic demographics, mechanism of injury, perioperative vitals and biochemical parameters. Injury severity was described by the Revised Trauma Score (RTS), Penetrating Abdominal Trauma Index (PATI), Injury Severity …