Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Estrogenic Activity"”.
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Estrogenic Activity of the Polybrominated Diphenyl Ether Flame Retardant Mixture DE-71
… mixture DE-71 and its in vivo metabolites for estrogenic activity. MCF-7 breast cancer cells culture, ERE-luciferase gene expression, 3H-β-estradiol displacement from recombinant ERα, and ovariectomized (OVX) mice served as bioassays. Although DE-71 did not bind ERα, it was able to increase …
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Factors affecting estrogen excretion in dairy heifers
… The objective of the first study was to quantify estrogenic activity in feces and urine during the estrous cycle. Ten non-pregnant Holstein heifers were fed the same diet for 28 d. Plasma, feces, and urine samples were collected daily. Plasma 17-β estradiol (17-β E2) was quantified with RIA and …
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The Development of Novel Non -Steroidal Subtype Selective Ligands for the Estrogen Receptor
… basic side-chains in the hope to impart anti-estrogenic activity to this class of ligands. The basic side-chain furan analogs were also ER-alpha binding selective ligands (2--47 fold selectivity) and transcriptional assays have shown one particular member of this series (Chapter 5, 17b) to be …
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Fate and Transport of Endocrine Disrupting Compounds during Wastewater Treatment: The Role of Colloidal and Particulate Material
The presence of biologically-active estrogenic endocrine disrupting compounds (EDCs) in treated effluents from biological wastewater treatment facilities has prompted wide-spread interest in the behavior of these contaminants during the activated sludge process. The yeast-estrogen screen (YES) was …
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A study on endocrine disrupters in the environment through the microarray technology
… is becoming increasingly relevant. The estrogenic activity of various compounds, described as xenoestrogens, is the major part of this debate. Humans beings are exposed to these substances from different environmental contaminations ranging from conscious intake of estrogenic substances, …
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Passive in-situ estrogenic potency sampling with DGT-YES
… assay, was deployed to quantify the total estrogenic potency of the compounds adsorbed to the DGT matrix. The unique dimension of this research was to extend the application of DGTs to estrogen sampling and to combine the DGT and YES technique to provide in situ quantification of the …
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The mechanism of T cell dysfunction induced by Diethylstilbestrol
… (DES), asynthetic estrogen, is known to have estrogenic activity and induce thymic alterations.We investigated the mechanism by which DES is able to alter T cells and thus theimmune system. First, we studied the effect of DES on mature T cells by using the T cellleukemia cell line, Jurkat. We …
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Electrophilic Affinity Labels and Fluorescent Conjugates for the Estrogen Receptor (Norhexestrol, Aziridine, Hexestrol, Fluorescein, Alkylator)
… norhexestrol aziridine derivatives retained the estrogenic activity of the parent hexestrol ligand as determined in human breast cancer cell growth experiments (MCF-7 cell line). Norhexestrol aziridine 34 ((6R*,7S*)-1-(N-aziridinyl)-6,7-bis(4-hydroxyphenyl)-5-nonanone) had the most potential as …
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Evaluation of the relationships between watershed-scale land use and contaminants in aquatic environments and the use of freshwater snails as indicators of impairment
… concentrations of dissolved nutrients and estrogenic compounds, measured as estrogenic activity, were directly related to watershed densities of AFOs. Population sex ratios of L. carinata varied across study sites, from balanced to female-biased, but were not related to concentrations of …
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Interactive Effects of Bazedoxifene acetate and Conjugated Equine Estrogens on the Breast and Reproductive Tract of Postmenopausal Monkeys
… maturation, and keratinization, while having no estrogenic activity when given alone. A comparable pattern was seen in the endocervical glands, but BZA only partially antagonized CEE effects on epithelial cell height. Interestingly, BZA with and without CEE resulted in lower ER alpha …
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Activation of proestrogens from hops by human intestinal bacteria: conversion of isoxanthohumol into the potent phytoestrogen 8-prenylnaringenin
… among individuals. As variability in biological activity was also noted for other phytoestrogens and related with variable intestinal bacterial metabolism, the goal of this work was to investigate whether intestinal bacteria also determine the final activity of hop phytoestrogens by combining …
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Mineral Surface Catalyzed Polymerization Of Estrogen And Microbial Deactivation By Fe3+-Saturated Montmorillonite: A Potentially Low Cost Material For Water Decontamination
… decontamination. 17β-Estradiol (βE2) has highest estrogenic activity among estrogens and is selected as representative compound. Rapid βE2 transformation in the presence of Fe3+ - saturated montmorillonite in aqueous system was observed and βE2 oligomers were the major βE2 transformation products. …
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Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth
… of estrogen metabolism toward formation of less estrogenic metabolites. Supplementation with the glucosinolate breakdown product indole-3-carbinol (I3C) has been shown to increase formation of 2-hydroxyestrogens, estrogen metabolites with weak estrogenic activity. However, the observed reduction …
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The effects of licorice root components on cognition
… pure compound found in licorice root with known estrogenic activity. LRE and LRP are both complex mixtures containing ISL as well as other components. Working memory was assessed in the DSA study. Middle-aged female rats were ovariectomized (OVX) and exposed to ISL (0, 6, 12, or 24 mg) once per …
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Science Based Authentication of Dietary Supplements: Studies on the Chemical Constituents, Analytical Method and Biological Activities of Scutellaria Spp and Pfaffia Paniculata
… cytotoxicity, antioxidant, anti-inflammatory, estrogenic activity and activations on peroxisome proliferator-activated receptor-alpha and -gamma (PARP and PPARγ). Neither skullcap extracts nor pure compounds tested shocytotoxicity against a panel of mammalian normal and solid tumor cell lines …
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Characterizing the fate and transport of chemicals of emerging concern (CECs) from swine manure during waste to energy processes
… and water quality. Natural occurrence of estrogenic hormones of swine manure from three different swine barns were investigated using a serial extraction method. Daily production of total hormones per pig were as follows: farrowing (1,333 ± 19 µg/day-hd) > gestation (789 ± 15 µg/day-hd) > …
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Investigating mechanisms of ovotoxicity of Perfluorooctanoic acid and Zearalenone exposure and the influence of altered metabolic status on ovarian function
… herein was ZEN, a non-steroidal mycotoxin with estrogenic activity that causes adverse effects on the female reproductive system, including altered folliculogenesis, decreased fertility, anovulation, vulvovaginitis, and altered follicle-stimulating hormone, progesterone, and 17-estradiol. Swine …
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Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… yet lack hormone-dependent transcriptional activity, highlighting the fact that steroid nuclear receptors can interact with chromatin in a transcriptionally inactive state (i.e., the majority of sNR chromatin interacting events identified in ChIP studies are not linked directly to …