Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Estrogen-independent"”.
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Micrornas That Affect Breast Cancer Growth, Metastasis And Estrogen-Independent Growth
… inhibits cell proliferation and anchorage-independent growth as well as cell invasion. Furthermore, mir-205 was shown to suppress lung metastasis in a mouse model. Finally, western blot combined with the luciferase reporter assays demonstrated that ErbB3 and vascular endothelial growth …
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
… cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and insulin receptor A (IR-A) both members of the tyrosine- kinase receptors family. The activation of Estrogen Receptor …
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The Interaction of Equol and Genistein on Estrogen Dependent Tumors and Bones in Ovariectomized Athymic Nude Mice
… of daidzein, with and without genistein on human estrogen dependent tumor growth and bone development in ovariectomized athymic nude mice. In the first study, the experiments were conducted to evaluate the effect of equol alone on the T47D human breast cancer cells and bone metabolism. At the …
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Overexpression of active AKT3 induces differential binding of coregulator proteins to the estrogen receptor as a possible mechanism of Tamoxifen resistance
<p>Tamoxifen is an effective anti-estrogen for treatment of women with hormonedependent breast cancer but acquired drug resistance limits its therapeutic benefit. We have previously reported that expression of active Akt3 in MCF-7 breast cancer cells results in estrogen-independent tumors that are …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
Estrogen, acting via estrogen receptor α (ERα), stimulates cancer cell proliferation and metastasis. Endocrine therapy targeting E2:ERα activity often leads to development of antiestrogen resistance. Approximately 30% of patients who have metastatic endocrine therapy resistant breast cancer express …
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Vitamin B6 Decreases Proliferation and DNA Synthesis in Human Mammary Carcinoma Cell Lines In Vitro
… is stimulated by the action of the hormone estrogen. Hormonal therapy used to treat these estrogen-dependent breast cancers acts by interfering with the action of estrogen. Current treatments, such as tamoxifen, are not consistently useful due to development of resistance to these drugs. …
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Combinatorial Modulation of Multiple Signaling Pathways to Gain Therapeutic Response in Breast and Prostate Cell Carcinomas
… to an in vivo animal model system using the estrogen dependent breast cell carcinoma line MCF-7 and the estrogen independent breast cell carcinoma line MDA-MB-231. This drug combination was shown to profoundly reduce tumor cell proliferation in vivo and also exhibited the ability to …
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The role of human DEAD-box protein DDX3X in the activation and function of Estrogen Receptor-alpha
… and TBK1. Interestingly, both DDX3 and IKKɛ have independently been shown to act as breast cancer oncogenes. In breast cancer, DDX3 expression was shown to be upregulated and linked with tumourigenesis. IKKɛ was suggested to phosphorylate Estrogen receptor alpha (ERα) at Serine-167 and drive …
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Effects of Frontal Hypothalamic Deafferentation on Seasonal Breeding and Secretion of Luteinizing Hormone, Prolactin and Melatonin in the Ewe
… Moreover, FHD did not alter photoperiod-induced, estrogen independent changes in luteinizing hormone (LH) secretion, but hampered photoperiod-induced, estrogen dependent changes in LH concentrations. This suggests that photoperiod signals, which regulate changes in the sensitivity of the H-H …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
… to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to cellular gene expression patterns. One gene that becomes highly upregulated is SPARC (secreted protein acidic and rich in …
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Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility
… evidence in support of peripheral production of estrogen by adipose tissue. In spite of the lack of estrogen at the host systemic and local (mammary gland) level, ovariectomized DS rats displayed elevated cancer multiplicity and sum tumor weight compared to ovariectomized DR rats, indicating that …
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Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
… used to study the underlying mechanisms of estrogen-mediated transcriptional regulation. Previously shown, estradiol-mediated transcriptional regulation in the mouse uterus is biphasic and can be divided into initial (early) phase and subsequent (late) phase transcriptional events. In this …