Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Estrogen receptor alpha"”.
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Circadian modulation of the estrogen receptor alpha transcription
… circadian disruption and the development of estrogen dependent tumors. The expression of estrogen receptor alpha (ERα) mRNA oscillates in a 24-hour period and, unlike Per2, ERα peaks during the light phase of the day. Because up regulation of ERα relates to tumor development, defining the …
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Characterization of estrogen receptor alpha in mouse osteoblasts
… in coordinating the reproductive function estrogens also affect the physiology of non-reproductive tissues such as bone. As a result they impact on the function of the two cell types operating bone homeostasis, osteoblasts and osteoclasts. Estrogens effects are entirely mediated by two …
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Regulation of estrogen receptor-alpha mediated gene expression and endocrine resistance through estrogen receptor-alpha phosphorylation and micro-RNA in breast cancer
Estrogens are associated with the development and progression of breast cancer in addition to their role in normal reproductive physiology, and estrogen receptors (ER) mediate the actions of estrogen in target tissues by regulating the expression of numerous biologically important target genes. The …
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Estrogen-receptor-alpha-positive breast and ovarian cancer: Therapy and mechanisms
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-03-28 without embargo terms
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DNA Repair, Redox Regulation and Modulation of Estrogen Receptor Alpha Mediated Transcription
Interaction of estrogen receptor alpha (ERalpha) with 17beta-estradiol (E2) facilitates binding of the receptor to estrogen response elements (EREs) in target genes, which in turn leads to recruitment of coregulatory proteins. To better understand how estrogen-responsive genes are regulated, our …
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The Role of Estrogen Receptor Alpha in Epididymal Sperm Structure and Function
Male mice deficient in ERalpha (ERalphaKO mice) are infertile and sperm recovered from the cauda epididymis exhibit reduced motility and fail to fertilize eggs in vitro. These effects on sperm appear to result from defective epididymal function and not a direct effect on spermatogenesis, as …
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Regulation of Estrogen Receptor Alpha Expression in Breast Cancer Cells by Sulforaphane
… cell lines and evaluated the effect of SUL on estrogen receptor alpha (ERalpha) protein and mRNA expression in MCF-7 cells. Our results show that SUL inhibits cell growth and proliferation in several breast cancer cell lines, and that SUL decreases ERalpha protein expression via suppression of …
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Cell Cycle Regulatory Roles of Estrogen Receptor Alpha (Erα) In Breast Cancer Cells
<p>Previous studies have shown that Estrogen Receptor alpha (ERα) is an important indicator for diagnosis, prognosis and treatment of breast cancers. However, the question remains as to the role of ERα in the cell in the presence versus absence of 17-β estradiol In this dissertation the role of ERα …
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Hormonal regulation of bone health: novel understandings of xenoestrogens and estrogen receptor-[alpha]
Estrogen is one of the most influential hormones on bone growth and maintenance throughout the life cycle in both men and women, but there are still unknown roles of estrogen and the estrogen receptors in males. In addition, exposure to xenoestrogens, or environmental compounds that have …
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A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… (E 2) action involves binding to estrogen receptor alpha (ERalpha) in target cells, interaction with estrogen response element (ERE)-containing DNA, recruitment of coregulatory proteins, and modification of estrogen responsive genes. Because DNA-induced conformational changes in …
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HEPATIC ESTROGEN RECEPTOR ALPHA ACTS AS A MOLECULAR TIMER ALIGNING LIVER METABOLISM TO PREGNANCY PROGRESSION
… e gli ormoni sessuali, in particolare gli estrogeni, regolano il metabolismo epatico agendo principalmente attraverso il recettore degli estrogeni α (ERα). ERα regola con precisione il metabolismo del fegato in relazione alle esigenze riproduttive e alla disponibilità di nutrienti. Questa …
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The Effects of Estrogen Receptor -Alpha, Estrogen and Phytoestrogen on Global Myocardial Ischemia -Reperfusion Injury
The effects of estrogen receptor-alpha on myocardial ischemia-reperfusion injury were investigated in male estrogen receptor-alpha knockout (ERKO) and wild-type control mice (Control). The effects of estrogen and phytoestrogen were investigated in 6 control mice (Control). The effects of estrogen …
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Physical activity and muscle function in females: Impact of ovarian hormones, bazedoxifene, and estrogen receptor alpha
… (Chapter 4). Additionally, I determined that estrogen receptor is likely the predominant receptor through which estradiol functions to elicit its effects on skeletal muscle fatigue (Chapter 4). Finally, due to declines in the clinical use of estrogen-based hormone therapy in postmenopausal …
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The role of human DEAD-box protein DDX3X in the activation and function of Estrogen Receptor-alpha
… IKKɛ was suggested to phosphorylate Estrogen receptor alpha (ERα) at Serine-167 and drive expression of ERα-responsive genes in an estrogen- independent manner, leading to cell proliferation and resistance to anti-estrogen treatment. The current study aimed to investigate whether DDX3 …
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Cross-Modulatory Actions of Estrogen Receptor Beta on Estrogen Receptor Alpha Transcriptional Activity in Breast Cancer Cells
Our observations indicate that the ability of ERalpha and ERbeta to serve as determinants of gene expression is greatly influenced by the nature of the ligand, ligand dose, and the ability of ligand-ER complexes to recruit coregulators at ER binding sites of hormone-regulated genes.
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Regulation of Gene Transcription by Estrogen Receptor Alpha: The Role of Cis Elements and Trans -Acting Factors
… of coregulatory proteins to DNA-bound ERalpha plays a critical role in mediating estrogen-responsive gene expression. We previously isolated and identified retinoblastoma-associated proteins 46 (RbAp46) and 48 (RbAp48), which are associated with chromatin remodeling, histone …
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Cross-modulatory Actions of Cell Cycle Machinery on Estrogen Receptor-alpha Level and Transcriptional Activity in Breast Cancer Cells
… of death of women in United States. The anti-estrogen tamoxifen which blocks gene expression through estradiol bound ERα, and hence the growth stimulatory effects of estradiol, has been widely used for decades for treating patients with ERα positive or hormone dependent breast cancer. Despite …
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Human Estrogen Receptor(alpha) Activity on Estrogen Responsive, Integrated Chloramphenicol Acetyltransferase (Cat) Reporter Constructs in Chinese Hamster Ovary (Cho) Cells
The estrogen receptors endogenous to CHO cells did not induce transcription of chromosomal copies of the more complex 2ERETKCAT promoter. In transient transfections hER$\alpha$ regulated transcription of the three 2ERETKCAT cell lines. We found that an ER mutant containing only AF1 elicited a dose …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
… leiomyomas may be mediated by the interaction of estrogen receptor alpha (ERα) and growth factor pathways and that phosphorylation of ERα at serine 118 (ERα-phospho-Ser118) is important in this interaction. In tissue, immunoblotting and immunohistochemistry were used to investigate the expression …
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