Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 88 for “"Estrogen Receptor (ER)"”.
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Potential Antiestrogen-Based Cytotoxic Agents and an Affinity Label for the Estrogen Receptor
… research involved studying the role of the estrogen receptor (ER) mediating the cytotoxicity of various tamoxifen derivatives in human breast cancer cells and examining estrogen structure and function using an affinity labeling compound, tamoxifen aziridine (TA).
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Analysis of Estrogen and Antiestrogen Receptor Complexes
I have used affinity labeling ligands for the estrogen receptor (ER) to examine the structure and relatedness of ER in different target tissues and species. In addition, I have characterized the first efficient and selective affinity labeling estrogen, ketononestrol aziridine (KNA).
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Estrogen Receptor and Progesterone Receptor Synthesis and Degradation in Target Cells
The rates of synthesis and degradation of steroid hormone receptors are crucial factors in maintaining hormone responsiveness in target tissues. It was the intent of this study to determine the turnover of the estrogen receptor (ER) and progesterone receptors (PR) in rat uterine and human breast …
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The synthesis and evaluation of estrogenic probes for in vitro and in vivo studies
Our research group has for over twenty years had a strong interest in developing molecular probes for steroid hormone receptors, and in particular, the estrogen receptor (ER), in order to further elucidate its structure and function, and to aid in the clinical evaluation and treatment of patients …
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Analysis of the roles of ligand and DNA binding in estrogen receptor action
… this work we provide evidence indicating that under standard cell culture conditions unliganded estrogen receptor (ER) is unable to activate transcription. Studies of Chinese Hamster Ovary cells which were grown under serum-free conditions, suggested that commercial base media may contain traces …
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
… of IGF2 are important in the growth and differentiation of normal breast. In breast cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and insulin receptor A (IR-A) both …
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The Phytoestrogen Genistein Induces Thymic and Immune Changes: A Human Health Concern
Use of soy-based infant formulas has aroused concern due to potential estrogenic effects of the soy isoflavones genistein and daidzein. Here we show that subcutaneous genistein injections in ovariectomized adult mice produced dose-responsive decreases in thymic weight of up to 80%. Genistein's …
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Design and Synthesis of Novel Core Scaffolds for the Development of Subtype Selective Estrogen Receptor Ligands
The Estrogen Receptor (ER) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily which plays a crucial role in bone maintenance, cardiovascular function and reproductive processes in both men and women. Although the two subtypes of ER---ERalpha and …
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Light-activated gene expression
… developed. This method uses the Nuclear Hormone Receptor (NHR) family as a model system. This tool provided an opportunity to study the spatial and temporal control of genes by using small synthetic molecules and light. In the late 1990s, we first demonstrated this concept by using as a …
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Role of Estrogenic Biomarkers in the Prediction of Disease Risk/Survival in Postmenopausal Women
The role of estrogens extends far beyond that of sexual development in females. Results from population-based studies indicate that estrogenic factors have a role to play in diseases affecting postmenopausal women. However studies investigating the role of estrogenic biomarkers in association to …
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I. Design and synthesis of estrogen receptor gene switches. II. Design and synthesis of estrogen receptor ligands occupying an auxiliary binding pocket
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic target for breast cancer, hormone replacement therapy, contraception, and osteoporosis. Novel organic cores have been identified and developed as possible estrogen pharmaceuticals. The x-ray …
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Interrelationships among estrogen, insulin-like growth factor-I and cyclic adenosine monophosphate in the regulation of uterine progesterone and estrogen receptors
Studies were undertaken to examine regulation of progesterone receptor gene expression and estrogen receptor bioactivity in uterine cells, and to determine the cellular mechanisms through which various factors mediate regulation of these receptor proteins. Exposure of uterine cells maintained in …
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Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
The estrogen receptor (ER) has become a major focus of biological and clinical investigation in diagnostic and therapeutic drug design for human breast carcinoma. Molecular probes, such as fluorine-18 radiopharmaceuticals, bivalent ligands, and affinity labels, provide information toward a better …
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Estrogen Inducible Proteinase Inhibitor 9 Protects Target Cells From Immune Surveillance and Apoptosis
To test the effect of estrogen receptor (ER) ligands that induce PI-9 on TRAIL-mediated cytotoxicity, we used MCF-7, human breast cancer cells. In MCF-7 cells, induction of PI-9 by 17beta-estradiol (E2) inhibited TRAIL-mediated cytotoxicity. This is the first demonstration that regulation of PI-9 …
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Molecular actions of estrogen agonists and antagonists and their interaction with the human estrogen receptor
Studies were undertaken to examine the interaction of estrogen agonists and antagonists with the human estrogen receptor (ER) and to examine the consequences of this interaction on the DNA binding and transactivating ability of the receptor. The functional role of cysteines in the hormone binding …
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A Novel Phytoestrogen that Acts as an Agonist for Human Estrogen Receptors.
Estrogen is the natural agonist of the estrogen receptor (ER). However, certain plant-derived compounds or phytoestrogens have been identified that mimic estrogens and act as agonists and/or antagonists of ERs, depending on subtype and target tissue. Understanding how phytoestrogens interact with …
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The Effects of Selenium on Estrogen-regulated Gene Expression in LNCaP Prostate Cancer Cells
<p>Prostate cancer is the most frequently diagnosed cancer in American men and the second leading cause of cancer deaths. Supplementation with Se has reduced the incidence of prostate cancer and Se status is inversely correlated with prostate cancer risk. One molecular mechanism by which high Se …
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We …
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Genistein Reduces Production of Proinflammatory Molecules in Human Chondrocytes
Previously, we reported that cartilage is an estrogen receptor (ER) positive tissue and that mRNA levels of ER increase in postmenopausal women with osteoarthritis. Based on our findings and those of other investigators, we hypothesized that local rather than circulating estrogen levels negatively …
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Crosstalk of TTC5 cofactor and the estrogen receptor in breast cancer
The estrogen receptor (ER) is a transcription factor that regulates a wide array of genesand whose activity is a determinant for the prognosis of diseases such as breast cancer.ER, through L-X-X-L-L (L=leucine, X=any amino acid) motifs, interacts with cofactorssuch as TTC5 (tetratricopeptide repeat …
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