Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Estrogen Deficiency"”.
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Cardiovascular Consequences of Estrogen Deficiency: Studies in Premenopausal Women
The influence of estrogen deficiency in physically active women with functional hypothalamic amenorrhea (ExFHA) on cardiovascular regulation is unknown. Three mechanistic studies compared cardiovascular responses to exercise and orthostatic stress in ExFHA women with responses in physically active …
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Bone fracture toughness of estrogen deficient rabbits
… changes with drug treatment, and estrogen deficiency, using fracture toughness, femoral neck fracture and histomorphometric analysis in an ovarectomized rabbit model.;No significant differences were found in fracture toughness, porosity, or femoral neck ultimate strength for any …
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Gingival MSCs Improve Bone Phenotype in Ovariectomy-Induced Osteoporosis via Programmed Cell Death Pathway
Estrogen deficiency-related osteoporosis is a skeletal system disorder that affects women after menopause taking a toll on financial and health institutions. Gingival Mesenchymal Stem cells (GMSCs) are a distinctive population of dental tissue-derived stem cells that possess uniquely high …
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Das ovariektomierte und glukokortikoid-behandelte Schaf als Großtiermodell für die Osteoporoseforschung
… used to quantify changes in ovine bone under estrogen-deficiency and glucocorticoid treatment. With DXA we monitored the progression of the loss of bone mineral density of integral bone at the central and the load-bearing skeleton. Peripheral QCT was employed to determine the different respons …
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The Molecular Mechanisms of Estrogen Receptor α on Two Single Nucleotide Polymorphisms to Regulate WNT Signaling in Osteoblasts
… to bone fracture. Genetic factors, estrogen deficiency, and dysregulation of the WNT signaling pathway contribute to the development of this disease. Genome-wide association studies have predicted that the single nucleotide polymorphisms (SNPs) rs2887571 and rs9921222 associate with …
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In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
… (by osteoblasts). In postmenopausal women, estrogen deficiency evokes increased osteoclastic activity and bone loss. Studies showed that B cells may participate in osteoclastogenesis via expression of osteoclast-related factors, such as receptor activator of NF-kappaB ligand (RANKL), …
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Examination of voluntary wheel running on markers of adipose thermogenesis in intact and ovariectomized female mice
Estrogen plays an important role in adipose tissue (AT) metabolism. Post-menopausal estrogen loss leads to increased abdominal fat and worsened metabolic outcomes. Exercise, known to enhance energy expenditure and promote AT browning, may offer therapeutic potential to mitigate these adverse …
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Effects of exercise and phytoestrogens on white adipose tissue health in estrogen deficient rodents
… and WAT inflammation. Exercise and dietary phytoestrogen interventions can improve metabolic and WAT health in menopausal women and OVX rodents. The studies in this dissertation were designed to investigate the visceral WAT underlying mechanisms to determine how voluntary wheel running (Chapter …
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Estrogen signaling interacts with Sirt1 in adipocyte autophagy
… which was associated with lower expression of estrogen receptor (ER) and more active autophagy in males vs. females. ER knockout normalized this difference. Mechanistically, E2-ER- mTOR-ULK1-autophagy signaling contributed to the gender difference in visceral fat distribution. Secondly, in …
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IDENTIFICATION OF MECHANISMS OF DELAYED PUBERTY ON BONE STRENGTH DEFICITS DURING DEVELOPMENT
… to result from a combination of ER and estrogen deficient environment. Studies replacing estrogen in hypothalamic amenorrhea or IGF-1 in anorexia alone have failed to improve bone mineral density (BMD), but a combination of IGF-1 and estrogen has been successful in improving BMD. This …