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Showing 1 to 20 of 80 for “"Estrogen -- Receptors."”.
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The Involvement of Estrogen Receptors in Astrocyte Survival
<p>Estrogens are a class of hormones that are demonstrated to be neuroprotective. The levels of estrogen in the body decline during menopause which can cause a variety of symptoms. Hormone replacement therapy (HRT) is a treatment option for menopause, however, it has been demonstrated to have …
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Breast Cancer Progression and Phytoestrogen Interactions with Estrogen Receptors
… genetic background is life time exposure to estrogen. Understanding the estrogen receptor (ER) has been a milestone in elucidating breast cancer biology, leading to advances in disease management. Alongside this, evidence from epidemiological studies suggests that dietary consumption of …
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Tamoxifen metabolites can target both aromatase and estrogen receptors
… two thirds of all diagnosed breast cancers are estrogen receptor (ER)-positive and are dependent on estrogen signaling. Drugs for the treatment of ER-positive breast cancer can be divided into three classes: selective estrogen receptor modulators (SERMs), selective estrogen receptor …
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Estrogen Receptors and Estrogen-Regulated Genes in the Male Reproductive Tract
Estrogen receptor-alpha (ERalpha) is essential for male fertility. The bisexual role and importance of estrogen in reproduction was established by the previous studies. However, there is considerable variation, both within and between species, in reports of nuclear steroid receptor localizations in …
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Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
By attaching the fluorophore directly onto the ligand-binding domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and …
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A Novel Phytoestrogen that Acts as an Agonist for Human Estrogen Receptors.
Estrogen is the natural agonist of the estrogen receptor (ER). However, certain plant-derived compounds or phytoestrogens have been identified that mimic estrogens and act as agonists and/or antagonists of ERs, depending on subtype and target tissue. Understanding how phytoestrogens interact with …
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
… cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and insulin receptor A (IR-A) both members of the tyrosine- kinase receptors family. The activation of Estrogen Receptor …
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Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins
Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in …
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Localization of P450 aromatase in sperm and estrogen receptors in the epididymal region of the rooster
… that appear to play a role. The presence of estrogen receptors (ER) in the male reproductive tract suggests that estrogen may be important for epididymal functions. This investigation was undertaken to test the hypothesis that estrogen has a role in the regulation of the male reproductive …
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Regulation of Gene Transcription by Estrogen Receptors Alpha and Beta: DNA Binding, Tethering, and Coregulatory Protein Recruitment
Combining various cis-elements and coregulatory proteins to regulate gene expression may allow for differential expression of the gene under different cell environments and physiological conditions. These studies will advance our understanding of the complex mechanisms by which ERalpha is able to …
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Localization and distribution of estrogen receptors and progesterone receptors in the bovine ovary in relation to the cell dynamics
… van het rund illustreert het belang van oestrogenen en progesteron in de fysiologie van het runderovarium. De topografische en nume-rieke gegevens bekomen uit deze studie kunnen van nut zijn voor verder onderzoek naar de specifieke rol van oestrogenen en progesteron in de regulatie van de …
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The Identification and Characterization of Estrogen Receptors in the Mouse and Human Lens and Their Role in Cataract Development
… women and studies in animal models suggest that estrogen may have a protective role in the lens. However, very little is known regarding the role of estrogen and its receptors in the lens. To begin unraveling the estrogen signaling mechanism in the lens, the following aims were investigated: 1) …
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
The nuclear hormone receptors, ERα and ERβ, are known to regulate the transcriptional response programs of their target cells, including breast cancer cells. However, their comparative abilities to localize at chromatin binding sites across the genome, and the recruitment of major coregulators such …
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Interrelationships among estrogen, insulin-like growth factor-I and cyclic adenosine monophosphate in the regulation of uterine progesterone and estrogen receptors
… of progesterone receptor gene expression and estrogen receptor bioactivity in uterine cells, and to determine the cellular mechanisms through which various factors mediate regulation of these receptor proteins. Exposure of uterine cells maintained in primary culture to estradiol, IGF-I, or to …
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The role of estrogen receptor manipulation on persistent fear memory induced by traumatic stress exposure
… explanation may be cyclic changes in vascular estrogen release, which may be a contributing factor to the higher prevalence of PTSD, though the role of estrogen receptors in modulating traumatic stress effects has been insufficiently explored. By using a well-validated PTSD model (single …
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Étude de la régulation de l'expression de PAX-5 et de ses isoformes dans le cancer du sein: implication des récepteurs d'oestrogène ERα et ERβ 3
… common type of cancer affecting women worldwide. Estrogen receptors ERα and ERβ are ligand-dependent transcriptional factors that mediate oestrogens biological effects, namely those of 17β-estradiol. They are expressed in the most cases of breast cancer and are well characterized for their role in …
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Part One: Iodinated Estrogens - Potential Photoaffinity Labeling and Tumor Localizing Agents for Estrogen Responsive Tissues. Part Two: Synthesis of a Hexestrol Derivative for Potential Use in Affinity Chromatography to Purify Estrogen Receptors
Made available in DSpace on 2014-12-13T20:09:38Z (GMT). No. of bitstreams: 1 7606804.pdf: 4754811 bytes, checksum: 5e28e9583b4f5a10e05d7cff564649b7 (MD5) Previous issue date: 1975
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Human Estrogen Receptor(alpha) Activity on Estrogen Responsive, Integrated Chloramphenicol Acetyltransferase (Cat) Reporter Constructs in Chinese Hamster Ovary (Cho) Cells
The estrogen receptors endogenous to CHO cells did not induce transcription of chromosomal copies of the more complex 2ERETKCAT promoter. In transient transfections hER$\alpha$ regulated transcription of the three 2ERETKCAT cell lines. We found that an ER mutant containing only AF1 elicited a dose …
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Integration of Nuclear- and Extranuclear-Initiated Estrogen Receptor Signaling in Breast Cancer Cells
Estrogenic hormones exert their effects through binding to Estrogen Receptors (ERs), which work in concert with coregulators and extranuclear signaling pathways to control gene expression in normal as well as cancerous states, including breast tumors. In this thesis, we have used multiple …
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Estrogen Receptor Regulation of Xenopus Laevis Vitellogenin Gene Expression
The mechanism by which the Xenopus laevis estrogen receptor mediates the transcriptional response of the vitellogenin gene was investigated. The Xenopus estrogen receptor (XER) cDNA was cloned and sequenced. It could encode a protein of 66 Kd, which is approximately the same size as human and …
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