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Showing 1 to 11 of 11 for “"Escherichia coli Proteins"”.
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Determining Structural Transitions That Occur Upon Gating a Bacterial Mechanosensitive Channel
… library of the transmembrane domains of E. coli MscL was created. I screened the mutants for their ability to react with MTSET before and after shock using whole-cell physiological assays. This in vivo SCAM study gave support for a clockwise rotation of TM1 predicted in another model, and …
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The Functional Characterization of QSEC a Bacterial Adrenergic Receptor and the LuxR Homologue SDIA in EHEC
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a human pathogen responsible for outbreaks of hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). The histidine sensor kinase QseC is an inner membrane adrenergic receptor which responds to the bacterial signal autoinducer-3 (AI-3) and …
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The Characterization of Quorum Sensing E. Coli Regulators E,F, and G (Qse EFG) and Their Role in Pathogenesis
Escherichia coli O157:H7 (EHEC) causes hemorrhagic colitis and life-threatening hemolytic uremic syndrome (HUS) worldwide. EHEC colonizes the large intestine and adheres to intestinal epithelial cells by forming attaching and effacing lesions (AE). These lesions result in the rearrangement of the …
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Regulation of WASP in Actin Signaling: From Angstroms to Microns
… regulation of WASP by an Enterohaemorrhagic E. coli (EHEC) effector EspFU. This study leads to novel mechanisms of WASP regulation and also sheds light on how cells conduct μm-scale assembly by orchestrating nm-scale proteins spatially and temporally. EHEC hijacks the host cytoskeleton during …
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The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42
… syringe, allowing bacteria to inject effector proteins directly into the host cell cytoplasm. These effectors commandeer and manipulate host signaling pathways to support the lifecycle of the particular pathogen. Common targets for these effectors are small GTPases, particularly those …
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Structural and Mechanistic Roles of Novel Chemical Ligands on Quorum Sensing Transcription Regulator SdiA in Enterohemorrhagic Escherichia coli
… (AHLs) [1]. However, some bacteria such as Escherichia coli (E. coli) do not produce AHLs and, therefore, their quorum sensing LuxR-type proteins are thought to be regulated by AHLs from other bacteria [2-4]. These sub-family of LuxR proteins known as LuxR solos can also regulate and detect …
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Characterization of Virulence Mechanisms in Vibrio parahaemolyticus
Pages xvi-xix are misnumbered as pages vi-ix.
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The Functional Characterization of the Quorum Sensing E. Coli Regulators B and C in EHEC
Enterohemorrhagic E. coli (EHEC) is the causative agent of hemorrhagic colitis. During an infection, EHEC can sense and respond to environmental cues, including the cell density of the intestinal normal flora (through the floral-derived AI-3 signal) and the epinephrine/norepinephrine produced …
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Post-Transcriptional Regulation of Virulence Genes by GlmY and GlmZ in Enterohemorrhagic E. Coli
Enterohemorrhagic E. coli O157:H7 (EHEC) is a major cause of foodborne illness and hemolytic uremic syndrome (HUS) throughout the world. One of the major virulence factors in this pathogen is a type III secretion system (T3SS) encoded by the locus of enterocyte effacement (LEE). EHEC uses this …
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Oxygen Sensing by the Aer and Tsr Receptors of Escherichia Coli
<p><em>Escherichia coli</em> senses the oxygen concentration of its environment via the Aer and Tsr receptors, and swims to an oxygen concentration that provides optimal energy generation. Aer and Tsr do not sense oxygen per se but, sense the internal energy state via the electron transport system …
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Structural Dynamics and Signaling Roles of the Aer PAS and F1 Regions
<p>The Aer aerotaxis receptor in <em>Escherichia coli</em> mounts such a rapid response to redox that <em>E. coli </em>changes its swimming behavior within 100 ms after an oxygen pulse. This receptor is a membrane-bound homodimer, and it monitors internal energy (redox) via an FAD cofactor bound to …