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Showing 1 to 20 of 26 for “"Erythropoietin (EPO)"”.

  1. Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes

    North, Morgan HunterVirginia Tech2020

    … Endothelial Growth Factor-A (VEGF-A) and HIF-Erythropoietin (EPO) pathways. RNA sequencing (RNA-Seq) data from our previously published experiments revealed a potentially novel VEGF-A splice variant with excision of the VEGF Receptor-1 (VEGFR-1)/Flt-1 binding domain, rendering this isoform …

    vt Repository record

  2. Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model

    Zhang, Ji2016

    … Extracellular signaling molecule, particularly erythropoietin (EPO), plays a critical role in this process by activating its receptor (EPOR) which is highly expressed in late erythroid progenitor cells. Although the molecular mechanisms of how EPOR signaling functions have not been entirely …

    tenn-hsc Repository record

  3. Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema

    Souvenir, Rhonda Andrea

    … smoother transitions from bench to the bedside. Erythropoietin (EPO), a hematopoietic growth factor that increases oxygen availability during hypoxia/ischemia is associated with cell survival and neuroprotection in: in vivo and in vitro models of hypoxia ischemia. However these studies hold …

    loma-linda Repository record

  4. NOVEL APPROACHES TO MODELING AND TREATMENT OF COGNITIVE DEFICITS IN NEUROPSYCHIATRIC DISEASES

    El-Kordi, Ahmed2012

    … Faktoren. Zweitens, der Effekt von Erythropoietin (EPO) auf die Verbesserung höherer kognitiver Funktionen (Lernen und Gedächtnis, Aufmerksamkeit und exekutiver Funktionen) bei Mäusen. Die Arbeit enthält ein Buchkapitel und drei Original-Erstautorpublikationen. Das Kapitel (El-Kordi …

    goettingen Repository record

  5. Signal Transduction Effects Induced by Erythropoietin in a HNSCC Model System

    Desai, Shreya2017

    … the body lacks mature red blood cells (RBCs). Erythropoietin (EPO) is a systemically circulating hormone in the body that regulates the production of RBCs and is applied to treat anemia. Recently, several studies implicated shortened life expectancy of cancer patients by EPO administration. It …

    vcu Repository record

  6. Studies on the specificities of <i>In Vivo</i> and <i>In Vitro</i> bioassays used in the potency determination of Therapeutic Erythropoietin

    Liefooghe, Emily ClaireThe Open University2006

    Erythropoietin (Epo), a kidney-produced cytokine, promotes the proliferation and differentiation of erythroid progenitors into mature red blood cells.<br></br><br></br>The <i>in vivo</i> biological activity of Epo is dependent on it being adequately glycosylated. Glycosylation is a variable process …

    the-open-u Repository record

  7. Erythropoietin treatment in anaemic patients at the Nephrology Unit of the Steve Biko Academic Hospital - a retrospective, cross-sectional study

    University of Pretoria2020

    … results from a decrease in the production of erythropoietin (EPO) by the failing kidney. CKD progression requires treatment with erythropoiesis-stimulating agents and iron supplementation to ensure sufficient erythrocyte production. Best clinical practice guidelines should be adhered to in …

    pretoria Repository record

  8. Design, synthesis, and biological evaluation of diketopiperazine based ionizable lipids for the in vivo delivery of messenger RNA

    Fenton, Owen S. (Owen Shea)Massachusetts Institute of Technology2016

    … lipids induce high concentrations of human erythropoietin (EPO) protein at therapeutically relevant doses of mRNA. Notably, LNPs derived from our lead compound OF-02 are the most potent mRNA delivery vehicle yet reported in the scientific literature. While the liver is implicated in many …

    mit Repository record

  9. Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer

    Larsson, Anna-MariaCenter for Molecular Pathology, Faculty of Medicine2012

    The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different …

    lund Repository record

  10. Erythropoietin Signaling in Pancreatic Beta Cells in Homeostasis and in Models of Type 1 and Type 2 Diabetes

    Choi, Diana2011

    … and treatment. Evidence has suggested that erythropoietin (EPO) exerts cytoprotective effects on non-erythroid cells. However, the in vivo role of EPO on the pancreatic β cells has not been evaluated to date. We hypothesized that EPO would have direct cytoprotective effects on the pancreatic …

    toronto-retro Repository record

  11. Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation

    Bulut, Gamze Betul2016

    Erythropoietin (Epo) is the primary cytokine that drives red blood cell production and signals through its receptor, the EpoR, on erythroid progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these …

    utswmed Repository record

  12. AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN

    Benderro, Girriso FutaraCase Western Reserve University School of Graduate Studies2013

    … vascular endothelial growth factor (VEGF) and erythropoietin (EPO) were increased during hypoxic exposure and diminished during subsequent re-oxygenation. However, expressions of cyclooxygenase-2 (COX-2) and angiopoietin-2 (Ang-2) were elevated during hypoxia as well as re-oxygenation. …

    ohiolink Repository record

  13. HIF, HAPE, and Hilltop rats: a paradox unfolding

    Engebretsen, Barbara J., author, Tucker, Alan, advisor, Miller, C. W., committee member, Gotshall, Robert, committee member, Cordain, Loren, committee memberColorado State University. Libraries2003

    … to cellular hypoxia, enhancing expression of erythropoietin (EPO), vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (NOS II), a potent generator of nitric oxide. Therefore, it was hypothesized that differences in HIF-1α activity or HIF-1 induced proteins would …

    colostate Repository record

  14. Genetic variants of EPO and EPOR influence cognitive core features of schizophrenia

    Friedrichs, Heidi2012

    Einleitung: Die positive Wirkung von Erythropoietin (Epo), ein hämatopoetischer Wachstumsfaktor, auf die kognitive Leistung ist bereits seit längerem bekannt, jedoch wurde dieser Effekt nahezu ebenso lang durch die Steigerung des Hämoglobinlevels erklärt. Selbst nach der Entdeckung von Epo und …

    goettingen Repository record

  15. The impact of erythropoietin on uraemic cardiomyopathy

    Smith, KatieUniversity of Hull2009

    … LVH), which contribute to heart failure. Erythropoietin (EPO) has evolutionised the treatment of the anaemia associated with CKD. The discovery that the EPO receptor is also expressed on cardiomyocytes highlights a role of EPO beyond haematopoiesis. However, little is known on the cellular …

    hull Repository record

  16. Regulation of human 5-aminolevulinate synthase 2 expression during erythroid differentiation and its role in x-linked sideroblastic anaemia.

    Dell'Oso, Tania2003

    … in controlling transcription of ALAS2 during erythropoietin (Epo) stimulated erythroid differentiation. In order to investigate the regulation of ALAS2 transcription in the context of red blood cell maturation, an erythroid cell line, J2E, that terminally differentiates in response to Epo …

    adelaide Repository record

  17. Identification of Epo-independent red cell progenitors : the E-cad+ progenitors

    Lemke, BrittUniversität Potsdam

    … Den Wachstumsfaktoren stem cell factor (SCF) und Erythropoietin (Epo) fällt dabei eine entscheidende Rolle zu. Unter ihrem synergistischen Einfluß lassen sich Epo-abhängige Zellpopulationen, die sich aus BFU-E und CFU-E Typ Zellen zusammensetzen, ausreichend amplifizieren (Panzenböck et al., …

    potsdam-diss Repository record

  18. Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease

    Sullivan, Timothy A.2016

    … cell death regardless of the underlying cause. Erythropoietin (EPO) exhibits neuroprotective effects in a variety of <em>in vitro</em> and <em>in vivo </em>models of neuronal cell death although its classical function is the regulation of red blood cell production. EPO crosses the blood brain …

    tenn-hsc Repository record

  19. Indirekte und direkte Methoden zur Detektion des Erythropoietindopings

    Schwenke, DirkTechnische Universität Dresden

    Das Problem des Missbrauchs von Erythropoietin (EPO) als Dopingsubstanz zur Steigerung der Ausdauerleistung wurde schlagartig weltweit durch den Skandal zur Tour de France 1998 bekannt. Das Internationale Olympische Komitee (IOC) führte ab 1992 Erythropoietin explizit auf der Liste der verbotenen …

    qucosa-diss

  20. The role of erythropoietin in the pathophysiology of anemia associated with trypanosomiasis

    Suliman, Hagir B.Virginia Tech1996

    … and livestock in sub-Saharan Africa. A blunted erythropoietin (Epo) response has been proposed as one possible mechanism that contributes to the nonresponsive anemia in trypanosome-infected cattle. The overall objective of this study was to examine the pathophysiologic role of Epo in the anemia …

    vt Repository record

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