Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Erythropoiesis"”.
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INVESTIGATING THE ROLE OF SPECIALIZED RIBOSOME DURING ERYTHROPOIESIS
… show that the pool of ribosomes changes during erythropoiesis. Selective ribosome profiling show that certain subsets of mRNAs, including those important in erythropoiesis, are preferentially bound to ribosomes containing these RPs. These mRNAs exhibit weaker translation initiation contexts, …
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Transcriptional divergence and conservation of human and mouse erythropoiesis
… in improving our understanding of mammalian erythropoiesis. Nonetheless, there are several examples of variation between human and mouse erythropoiesis. We performed a comparative global gene expression study using data from morphologically identical stage-matched sorted populations of human …
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Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity
Assays that predict toxicity are an essential part of drug development and there is a demand for efficient models to better predict human responses. The in vivo micronucleus (MN) assay is a robust toxicity test that assesses the genotoxic effect of drugs on adult bone marrow (BM) using the metric …
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The Roles of Krüppel-like Transcription Factors KLF1 and KLF2 in Mouse Embryonic and Human Fetal Erythropoiesis
… to understand their role in all aspects of erythropoiesis before they are used for therapy. The current study focuses on the role of two Krüppel-like transcription factors, KLF1 and KLF2, which have known roles in the processes of primitive and definitive erythropoiesis as well as globin …
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Genetic analyses of the Rb and p53 genes in murine development and tumorigenesis
… in midgestation accompanied by defective erythropoiesis. Rb-l- embryos also exhibit inappropriate cell cycle activity and apoptosis in the central nervous system (CNS), peripheral nervous system (PNS), and ocular lens. Loss of p53 can prevent the apoptosis in the CNS and lens; however, the …
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Determinants of GATA1-mediated gene regulation during erythroid maturation
… Within this branch of development, erythropoiesis is the process through which mature red blood cells arise from progenitor cells. In this context, GATA1 is widely considered to be the master transcription factor for erythropoiesis, controlling the expression of a vast majority of …
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The regulation of human iron metabolism in hypoxia
… at sea level. Altitude exposure enhances erythropoiesis and iron-dependent oxidative and glycolytic enzyme production, for this reason, athletes must maintain a healthy iron balance at altitude. A negative iron balance at altitude may limit such physiological adaptations, potentially …
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The biogenesis of erythropoietin during inflammation
… to result primarily from the suppression of erythropoiesis by inflammatory cytokines. A contributing factor could be the inhibition of erythropoietin synthesis which may also be mediated by cytokines. Erythropoietin is the hormone which regulates erythropoiesis. The aims of this project were …
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Stage-Specific Multiomic Analysis of Human Erythroid Differentiation
… symptom of many diseases. RBC transfusion and erythropoiesis-stimulating agents (ESAs), primarily erythropoietin (Epo) and its analogs, are major treatments for anemia, but often lead to organ damage and/or ESA resistance. Understanding the mechanisms of Epo-dependent erythroid differentiation …
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ATHEROSCLEROSIS AND ENDOTHELIAL DYSFUNCTION IN THALASSEMIA
… we discovered that sTfR, a marker of ineffective erythropoiesis, is greater in TNDT patients and in patients with atherosclerotic plaque, suggesting a possible role of ineffective erythropoiesis in atherosclerosis pathophysiology. Conclusion In conclusion, this is the largest group of beta …
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Modulation of lineage-specific cell differentiation by long non-coding RNAs
… enucleation. To study how lncRNAs regulate erythropoiesis, we focused on EC6, an unpolyadenylated lncRNA needed for silencing neighboring loci encoding NF-kB activators. De-repression of these genes upon EC6 knockdown leads to activation of NF-kB and other immune pathways that antagonize …
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Repression Of Autophagy During Erythroid Development By Gfi1b
<p>Erythropoiesis, the production of red blood cells, is an essential process in mammals. The unique shape and composition of red blood cells requires the removal of cellular organelles and macromolecular structures during the maturation of these cells. This clearance is orchestrated by the …
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The Roles of Krüppel-Like Factor 1 (KLF1) in the Human Fetal Erythroid Compartment.
… factor with roles in embryonic and adult erythropoiesis. KLF1 knockout mouse embryos die due to severe anemia. Dominant human mutations in KLF1 can cause hereditary persistence of fetal hemoglobin. We show that KLF1 positively regulates β-globin and Bcl11A gene expression using KLF1 …
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Analysis of Mouse EKLF/KLF2 E9.5 Double Knockout: Yolk Sac Morphology and Embryonic Erythroid Maturation
… EKLF is involved in primitive and definitive erythropoiesis; KLF2 is implicated in the development of primitive erythroid and endothelial cells of the vasculature. Using light and electron microscopy, the yolk sacs and dorsal aortae from EKLF/KLF2 double knockout (KO) E9.5 (embryonic day 9.5) …
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The roll of integrins in hematopoiesis
… for [alpha]401 but not [alpha]501 integrins in erythropoiesis and provide evidence that erythroid differentiation and expansion are regulated by separate processes.
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Valproic Acid Disrupts Hematopoiesis in Xenopus Laevis Through the Inhibition of Histone Deacetylase 3.
… and is specifically required for primitive erythropoiesis. We also describe here that runx1 is activated by bmp4 in an HDAC-dependent manner. Consistent with this, restoring runx1 expression partially rescues VPA mediated hematopoietic defects. We further identify that the effects of HDAC …
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Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital
… No patient venesected for nonclonal erythropoiesis developed thrombocytosis. JAK2 mutation analysis applied with the WHO diagnostic algorithm efficiently differentiated true clonal myeloproliferation from reactive cytoses. Lifestyle and metabolic factors such as smoking and thrombosis …
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Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
… EPOR signaling in both Friend disease and normal erythropoiesis. Here we showed that EPOR signaling is not essential for Friend virus-mediated erythroblastosis. However, both EPOR and signal transducer and activation of transcription 5 (STAT5), one of its downstream components, are required for …
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