Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Error-corrected sequencing"”.
-
EVALUATION OF THE RISK OF SECONDARY LEUKEMIAS IN CANCER SURVIVORS
… chemotherapy. We used high-sensitivity error-corrected sequencing (limit of sensitivity VAF>0.1%) for CH analysis, in order to detect mutations well below the cutoff of the clinical threshold of CHIP (variant allele frequency (VAF) >2%). In both cohorts, pathogenic germline mutations …
-
Investigating clonal hematopoiesis in rhesus macaque and human
… of hematological malignancies, recent large deep sequencing studies have revealed that clonally-expanded HSPC with specific somatic mutations are also prevalent in individuals without overt hematological abnormalities and become increasingly common with age. The phenomenon is thus termed …
-
The evolutionary dynamics of clonal haematopoiesis and its progression to acute myeloid leukaemia
… haematopoiesis driver mutation. Using blood sequencing data amassed from ~50,000 individuals, combined with insights from evolutionary theory, we developed a framework to quantify the mutation rates and fitness effects of clonal haematopoiesis variants down to single nucleotide resolution. …