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Showing 1 to 13 of 13 for “"Ergothioneine"”.
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Synthesis of Mycobacterial Ergothioneine biosynthetic pathway metabolites
… glutathione and produce mycothiol (MSH) and ergothioneine (ESH) as their principal low molecular mass thiol instead. Ergothioneine has been known for a while as an anti-oxidant; however its role as a protective thiol in Mycobacterium tuberculosis is still undefined. Present knowledge …
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Conditions affecting ergothioneine levels in Mycobacterium smegmatis & the attempted isolation of α-N, N, N-Histidine methyltransferase, the first enzyme in ergothioneine biosynthesis
Ergothioneine and mycothiol are the two major low molecular weight thiols present in mycobacteria. The generation of mycothiol-deficient mutants has demonstrated its role in protecting M tuberculosis against oxidative and nitrosative stress. To date, no ergothioneine-deficient mutants have been …
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The Redox and Systems Biology of Ergothioneine Biosynthesis in Aspergillus fumigatus
Ergothioneine (EGT) is a tri-N-methylated and sulphurised histidine derivative which exhibits antioxidant properties. EGT was first identified in Aspergillus fumigatus, in work pertaining to gliotoxin biosynthesis. Compared to wild-type, EGT levels were elevated in the absence of GliK, a gliotoxin …
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Developing Budding Yeast as a Cell Factory for Production of the Antioxidant Ergothioneine
Ergothioneine (EGT) is a naturally occurring sulphur-containing modified amino acid which has been shown to exhibit anti-oxidant properties. EGT is produced by selected fungi and prokaryotes, however Saccharomyces cerevisiae does not naturally produce EGT. Up to 5 genes are involved in bacterial …
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Synthesis of thiohistidines and its metabolic pathway precursors
Natural thiohistidines such as ergothioneine and ovothiols are biosynthesized by actinomycetes, fungi and many parasitic protozoa, respectively. Actinomycetes such as Mycobacterium tuberculosis produce mycothiol and ergothioneine as their principal low molecular mass thiols. It is only very …
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Application of Advanced Bioanalytical Techniques to Studies of Oxaliplatin Chemotherapy
… when given with OCT inhibitors (cimetidine or ergothioneine) for modulating oxaliplatin toxicities. To quantify intact oxaliplatin in human plasma, an ultraperformance liquid chromatographyinductively coupled plasma mass spectrometry bioanalytical method was developed and validated. This …
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Effects of ergothioneine on endothelial cell and macrophage characteristics, and markers of atherosclerosis risk under high lipid conditions
Ergothioneine (EGT) is an antioxidant and potential anti-inflammatory molecule that may have protective effects against the lipid-induced oxidative stress and inflammation that occurs in the vasculature of individuals with obesity and metabolic syndrome. This thesis addresses the hypothesis that …
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Effect of Dried Mushroom Powder on Thiol Content in Lyophilized and Native Bovine Myofibrillar Protein
… <em>P. ostreatus</em> contained 164% more ergothioneine than lyophilized <em>A. bisporus</em> and oven-dried <em>P. ostreatus</em> contained 70% more ergothioneine than oven-dried <em>A. bisporus</em>. Free thiols were higher in native myofibrillar protein with 0.1% added <em>P. …
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A Global and Targeted Proteomic Investigation of Aspergillus fumigatus
… with significant elevation in intracellular ergothioneine levels (p < 0.001). This study describes the first identification of ergothioneine in A. fumigatus and represents a target for future redox investigations.
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Applications of metabolomics to study the pathophysiology of adverse pregnancy outcomes
… analysis of plasma from experiments examining L-Ergothioneine treatment in the Reduced Uterine Perfusion Pressure (RUPP) rat model of pre-eclampsia. The effect of L-Ergothioneine (ET) treatment was explored using in vivo treatment in rats: Sham control (SC, n=5), RUPP control (RC, n=5), Sham + ET …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… acid sulfate [GCDCA-S], levocetirizine, ergothioneine, and atenolol) for the major renal uptake transporters (OAT1–4, OCT2, OCTN1/2) and for renal efflux transporters (P-gp, BCRP, MRPs, MATE1/2-K) using transporter-overexpressing HEK293 and MDCK-II cells and Sf9 membrane vesicles. …