Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ErbB-2"”.
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Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast Cancer
<p>The ErbB-2 gene is amplified and the resulting protein product overexpressed in 15-30% of breast tumors, and associated with aggressive behavior and poor overall survival. Currently, there are two FDA approved therapies targeting ErbB-2 for the treatment of ErbB-2 positive breast cancer: …
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Biomarcadores moleculares no esôfago de Barrett: análise comparativa da imunoexpressão tecidual do p53, c-erbB-2, E-caderina, COX-2 e KI-67, na esofagite por refluxo, no esôfago de Barrett e no adenocarcinoma associado ao esôfago de Barrett
… tecidual dos seguintes biomarcadores: p53, c-erbB-2, Ecaderina, COX 2 e Ki-67. As imunorreações qualitativas com p53, COX-2 e c-erbB-2 revelaram maior expressão no grupo III, contrastando com a positividade menor e decrescente dos grupos II e I (p<0,001; p=0,002; p<0,001, respectivamente). O …
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Biophysical characterization of high affinity engineered single chain Fv antibody fragments
… affinity modulation in proteins. First, anti-c-erbB-2 antibodies and their binding partner, the extracellular domain of the glycoprotein tumor antigen c-erbB-2, were examined. Thermodynamic studies were carried out on the originally identified human scFv and three higher affinity mutants. …
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Expressão de HER-2/neu e p53 em adenocarcinoma de esôfago e cárdia
A incidência de adenocarcinoma de esôfago e cárdia tem aumentado nas últimas décadas por razões ainda não conhecidas. São doenças da civilização ocidental. A incidência de adenocarcinoma de esôfago e carcinoma de cárdia ultrapassou a de carcinoma epidermóide de esôfago. O desenvolvimento da …