Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Epstein - Barr virus (EBV)"”.
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CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
Epstein-Barr virus (EBV) is a human herpesvirus that infects more than 95% of the world’s population by adulthood. Like other herpesviruses, EBV has a biphasic infection cycle which includes latent and lytic programs. Upon primary infection, the virus establishes a lifelong latency in memory B …
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Modulation of innate immune responses in nasopharyngeal epithelial cells by the Epstein-Barr virus (EBV)-encoded latent membrane proteins LMP2A and LMP2B
The Epstein-Barr virus (EBV)-encoded Latent membrane proteins (LMP) 2A and LMP2B are frequently expressed in a number of EBV-associated malignancies. Although the true function of these proteins remains to be elucidated, LMP2A appears to function as a surrogate B-cell receptor in B-cells, …
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An investigation of Epstein-Barr Virus (EBV) latency type and MYC gene aberrations in plasmablastic lymphoma diagnosed at Groote Schuur Hospital, Cape Town, South Africa
… understood, however association with the Epstein-Barr virus (EBV) and the MYC gene, have been identified as important pathogenic mechanisms. Aims and objectives: To characterise the EBV latency in a cohort of patients diagnosed with PBL at Groote Schuur Hospital (GSH), by means of …
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Atypical reactive lymphoid hyperplasia : a 5 year study with analysis of 10 cases for latent Epstein-Barr virus infection by in situ hybridization and immunohistochemistry
… up IN SITU HYBRIDIZATION (ISH) for detection of Epstein-Barr virus (EBV)-encoded RNA's (EBERs) in latently infected cells in selected cases, to determine if virus is present in ARLH. 3. To perform immunohistochemical analysis for the detection of EBY-derived latent membrane protein (LMP) in those …
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Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
Epstein-Barr virus (EBV) is a human B-cell tropic double-stranded DNA y-herpesvirus. To date, there are no antiviral agents proven to be clinically effective in the treatment of EBV infection or EBV-associated diseases. In the experiments contained in this thesis, we define the ability of …
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THE ROLE OF TYPE I INTERFERONS IN THE HOST CD8+ T CELL RESPONSE DURING GAMMAHERPESVIRUS INFECTION
The human gammaherpesvirus Epstein-Barr virus (EBV) is associated with multiple forms of cancer. Suppressing gammaherpesvirus reactivation and latency is a potential therapeutic target in the prevention or treatment of EBV-associated cancers. CD8+ T cells are crucial to the control of both lytic …
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A BIOMARKER ENRICHMENT PHASE II TRIAL OF 177LU-DOTATATE IN METASTATIC NASOPHARYNGEAL CANCER WITH A SAFETY RUN-IN
… found that SSTR2 expression is induced by the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via the NF-κB pathway and SSTR2 expression can be seen in vitro and in vivo in certain other EBV related cancers (NCT05581550). We also report the initial results of our phase 2 therapeutic …
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Humanized Mouse with a Diverse Polyclonal B Cell Repertoire as a Model for Neutralizing Antibody Responses against EBV and HIV
Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV) cause diseases of global health importance. However, it has been historically difficult to model human neutralizing B cell responses to these two viruses using small animals. I leveraged a transgenic mouse model that encodes a …
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TREATMENT AND MODELING OF EPSTEIN-BARR VIRUS POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER
Epstein-Barr virus (EBV) is the etiological agent of infectious mononucleosis and is associated with various diseases such as Burkitt’s lymphoma, nasopharyngeal carcinoma, and post-transplant lymphoproliferative disorder (PTLD). In all of these diseases, the expression of Epstein-Barr virus nuclear …
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CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation
… functions and cell differentiation. As Cytomegalovirus (CMV) infection influences CD8TL differentiation, Chapter 3 compared the mobilization of cytotoxic lymphocytes in CMV seropositive and seronegative individuals; CMV infection enhanced the stress reactivity of CD8TLs, CD4TLs and NKT-like cells. …
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Überexpression von s-Adenosylhomocystein-Hydrolase (SAH) in Zellen der Epstein-Barr Virus-Genom positiven Zell-Linie B95-8
The Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with tumors like Burkitt's lymphoma or Hodgkin's lymphoma. In this thesis, the overexpression of s-adenosylhomocystein hydrolase (SAH) was analyzed in EBV genome positive B95-8 cells. The focus of the examination has …
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A TOLL-LIKE RECEPTOR-INDUCIBLE AND B CELL-SPECIFIC ENHANCER REGULATES MURINE GAMMAHERPESVIRUS 68 LATENCY AND REACTIVATION
Murine Gammaherpesvirus 68 (MHV68) is a natural pathogen of rodents and is related to the human pathogens Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). MHV68, EBV, and KSHV are lymphotropic and are associated with a variety of lymphadenopathies, carcinomas, and …
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Control of the EBV growth transformation programme: the importance of the Bamhi W repeats
Epstein-Barr virus (EBV), a human gammaherpesvirus, possesses a unique set of latent genes whose constitutive expression in B cells leads to cell growth transformation. The initiation of this B-cell growth transformation programme depends on the activation of a viral promoter, Wp, present in each …
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The role of cellular micro-RNAs in Epstein-Barr virus induced cellular transformation and oncogenesis
… post-transcriptionally regulate gene expression. Epstein-Barr Virus (EBV) transforms resting B-cells in vitro to establish continuously proliferating lymphoblastoid cell lines (LCLs) and is aetiologically linked to lymphomas. Little is known about the contribution of miRNAs to the transformation …
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An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
Although Epstein–Barr virus (EBV) usually establishes a harmless infection in human memory B cells, it is implicated in the development of germinal centre (GC) B-cell-derived malignancies, including Hodgkin’s lymphoma (HL). I have shown using gene expression profiling that lymphoblastoid cell lines …
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Maus-Herpesvirus-68-(MHV-68)-Infektion : Modell für die Epstein-Barr Virus-Infektion des Menschen
Epstein-Barr virus (EBV) infection in children may cause severe central nervous system infection with neurological complications like epilepsia and enzephalitis. The well-established model of the EBV-related mouse herpes virus 68 (MHV 68), was not applicable for infections of the central nervous …
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Temporal Regulation of LMP1 and Apoptosis Resistance After Primary EBV Infection
<p>Epstein-Barr virus (EBV) is a ubiquitous human pathogen that establishes a lifelong latent infection in over ninety percent of all adult humans worldwide. While typically benign, EBV has been causally associated with a number of human malignancies in the settings of immune suppression, genetic, …
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Treatment outcomes of Epstein-Barr virus associated nasopharyngeal carcinoma with three-dimensional conformal radiotherapy: A retrospective review
Background: Data on treatment outcomes of Epstein-Barr virus (EBV) associated nasopharyngeal carcinoma (NPC) largely comes from endemic regions. There is limited literature available regarding the epidemiology and treatment outcomes of EBV associated NPC in South Africa. Aim: The primary aim of the …
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The role of latent membrane protein 2 in the pathogenesis of Epstein-Barr virus associated malignancy
Epstein-Barr virus (EBV) establishes a lifelong latent infection in host B cells and is associated with the development of various lymphoid and epithelial malignancies. Approximately half of Hodgkin's lymphomas (HL) are EBV positive where LMP2 is highly expressed. However, the contribution of LMP2 …
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Identification of Epstein-Barr virus proteins that inhibit the DNA damage response
Epstein-Barr virus (EBV) is a common herpesvirus that is the causative agent of mononucleosis and can also induce a variety of B cell lymphomas and carcinomas. To promote viral replication and cell survival, EBV is known to manipulate the cellular DNA damage response (DDR). To date there have only …
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