Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Eplerenone"”.
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
… of the mineralocorticoid receptor antagonist eplerenone, in a cohort of 100 patients admitted with AMI, with depressed LV ejection fraction (LVEF) but without HF or diabetes mellitus, using a gold standard modality for LV functional assessment and infarct imaging: late gadolinium-enhanced …
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Role of 11β-hydroxysteroid dehydrogenase type 2 in protection against inflammation during atherogenesis: studies in the Apoe-/- /11β-HSD2-/- double knockout mouse.
… DKO mice received either the MR antagonist eplerenone (200mg/kg/day) or vehicle in normal chow diet from 2 months of age for 12 weeks. Eplerenone significantly decreased atherosclerotic burden in brachiocephalic arteries of DKO mice, an effect that was accompanied by alterations in the …
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Renal Epithelial Sodium Channel (ENaC) Regulation of Pregnancy Mediated Hemodynamic Adaptations: Mechanistic Insights
… with the mineralocorticoid receptor antagonist, eplerenone. These findings demonstrate that the increased α ENaC subunit of pregnancy is associated with a mineralocorticoid-dependent increase in ENaC activity. The plasma volume increased progressively during pregnancy with the greatest plasma …
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Ο αποκλεισμός των υποδοχέων της αλδοστερόνης στην ασβέστωση της αορτικής βαλβίδας
Η ασβέστωση της αορτικής βαλβίδας σχετίζεται με αυξημένη νοσηρότητα και θνητότητα, ιδιαίτερα στους ηλικιωμένους. Μέχρι σήμερα η φαρμακευτική θεραπεία δεν έχει αποδειχθεί τόσο αποτελεσματική, όσο η χειρουργική. Στην παρούσα εργασία χρησιμοποιήθηκε μοντέλο υπερλιπιδαιμικών κονίκλων προκειμένου να …