Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Epitranscriptomics"”.
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Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
The epitranscriptome -- the naturally occurring system of chemical modifications on ribonucleic acid (RNA) --
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Modulation of RNA Cytosine-5 Methylation by Neuronal Activity and Methyl-donor Folate
RNA epigenetics or Epitranscriptomics has emerged as a new field for understanding the post-transcriptional regulation of gene expression by RNA modifications. Among numerous types of RNA modifications, RNA cytosine-5 methylation (5-mrC) is recognized as an important epitranscriptomic mark that …
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Evaluation of Computational and Experimental Parameters in RNA Bisulfite Sequencing Analysis and Applications in Brain Development Studies
Epitranscriptomics, the study of RNA modifications, has become a hotspot of research over the last decade. Over 170 unique modifications have been discovered with a widespread occurrence in a diverse range of RNAs. 5-methylcytosine, m5C, is an evolutionarily conserved and reversable modification …
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Role of N6-Methyladenosine (m6A) epitranscriptomic mechanisms in manganese-induced astrocyte inflammation
… writing, namely that of N6-methyladenosine (m6A) epitranscriptomics and its regulatory tiers that control the writing, erasing, and reading of m6A modified RNAs. We find that the global m6A modifications are significantly affected in Mn exposed astrocytes. More specifically, our findings suggest …
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Establishing new approaches to unveil regulatory functions of tRNAs and their interactors
The discovery of the genetic code transformed the life sciences by providing an analytical framework to study living systems. However, once the role of tRNAs was established in protein synthesis, the field moved on to other areas of the RNA world. With the mainstream application of systems-wide …
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Role of RNA methyltransferases in lung cancer
In recent years, RNA-modifying enzymes have gained significant attention because their activities are relevant to cancer biology, and they are therefore potential targets for novel therapeutic intervention. Here, I target validated two RNA methyltransferases. I performed a late-stage study of …
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Characterisation of RNA modifications in human cancer cells
Chemical modifications have been studied as key modulators of RNA biology for over 50 years. There are now 171 RNA modifications that have been discovered throughout the three kingdoms of life1. These chemical changes overlay the standard RNA information and have been linked to a wide range of …