Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 303 for “"Epitopes"”.
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Aspects of autoantibody epitopes in type 1 diabetes
… this thesis was to investigate the autoantibody epitopes of ZnT8 and NPY in newly diagnosed T1D patients as well as in patients with long-term T1D and T2D. Our data in paper I and IV suggests that the polymorphic 325 variant is a major determinant of a conformation-dependent ZnT8A epitope. …
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Expression of foreign epitopes in CS3 fimbriae / Bagher Yakhchali.
Aims to develop the CS3 pile of CFA/II+ of enterotoxigenic E. coli as a delivery system for the expression of foreign antigenic determinants to the bacterial cell surface, and to make an immunogenic ST toxoid as a step towards a vaccine against Enterotoxigenic E. coli.
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Elucidation of antigenic epitopes on the rubella virus E1 glycoprotein
… The mutants containing the functional epitopes were further studied by using synthetic peptides. HA epitope was mapped to amino acid residues E1214 to E12„ while two VN epitopes mapped to amino acid residues E1214 to E12, and E1219 to E1232. The potential use of the defined epitopes in …
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Use of peptide microarrays for mapping viral b cell epitopes
Entdeckung von Bindungsstellen für Antikörper, besonderes solcher, die Viren neutralisieren, ist von großem Nutzen zur Überprüfung eines Impfschutzes aber auch für die Entwicklung neuer Vakzinen und diagnostischer Reagenzien. Herzu wundern verschiedene Methoden benutzt, wie z.B. Phagen-Bibliotheken …
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Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition
… structural homology and that HAMLET targets epitopes shared by molecules critical for cell survival. By protoarray, HAMLET targets represent protein families critically involved in energy metabolism and cellular homeostasis including ATPases, kinases and small GTPases. In an in vitro kinase …
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Designing antibodies to defined epitopes: Immunoassays as structural and analytical probes
Dissertation (Ph.D.)--University of Kansas, Chemistry, 1995.
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New insights into molecular recognition of epitopes related to MUC1 human mucin by lectins
… have synthesized different representative MUC1 epitopes bearing Ser and Thr in their structure and we have detected differences between these two amino acids in terms of affinity to lectins. As a result, it is important to mention specifically the underlying amino acid in Tn antigen. We have …
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Investigation of the interplay of yellow fever virus structural protein epitopes and genetic diversity
… tropism was correlated with WT and vaccine epitopes as residues in EDI were critical to viscerotropism and WT mAb recognition and residues within EDIII were shown to be critical to neurotropism and vaccine mAb recognition. It was found that the attenuating processes of 17D were not …
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Systematic development of rationally designed antibodies targeting predetermined epitopes of interest and protein aggregation
… in establishing antibodies against pre-selected epitopes is the effectiveness of the target regions to behave as antigens. To address this problem, a method of rational design was recently established in our group to construct complementary peptides in the complementarity determining regions …
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In silico prediction of C57BL/6 mouse T-cell epitopes: enhancing immunogenicity assessment with PREDBL6
… MHC and recognized by T cells are called T-cell epitopes. MHC class I–restricted T cell epitopes play a crucial role in the immune surveillance of intracellular pathogens. As MHC binding is considered the most selective step in T cell recognition, many existing bioinformatics systems focus on …
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Recognition of hepatitis B epitopes by T cell receptors and T cell receptor-like antibodies
… specific for immuno-dominant hepatitis B virus epitopes, the core protein peptide 18-27 (Core18-27) and the envelope protein peptide 183-191 (Env183-191), both restricted by the human HLA-A*02:01 class I MHC. Both murine monoclonal antibodies exhibited specificity and high affinity for their …
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The screening of neutralising antibodies against a resistant HIV-1 strain to identify novel epitopes
… tested against it (which target various epitopes on the HIV-1 envelope). QH343.A10 is resistant to monoclonal antibodies (mAbs) b12 (anti-CD4-binding site), 2G12 (anti-V3/glycan), 2F5 and 4E10 (both anti-membrane proximal external region). Of note, the virus is resistant to the extremely …
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Incorporation of tumor antigen epitopes into cytokine signal peptides enhance the efficacy of immuno-gene therapy
… cytokine production by expression of antigen epitopes within cytokine signal peptides. We first investigated the possibility of modifying cytokine signal peptides with antigen epitopes without aborting function. We inserted the genes encoding the MHC class I restricted antigenic epitopes of …
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Identifying B-cell epitopes of African horse sickness virus serotype 4 recognised by antisera of immunised horses
… antigenic regions could be fused with T-cell epitopes, identified in a parallel study, to form a construct that might induce production of humoral and cellular immune responses.
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Structural and electrostatic analysis of HLA B cell epitopes: Inferences on immunogenicity and prediction of humoral alloresponses
… of multiple discrete regions, ostensibly epitopes, can further improve the prediction of the HLA alloimmune response.
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The localization of two epitopes recognized by the monoclonal antibody PCG-4 on toxin A of Clostridium difficile
… the MAb PCG-4 is binding to two or more similar epitopes on the toxin. The goal of this research project was to identify the neutralizing epitopes recognized by the MAb PCG-4 on the surface of the toxin A. To map the epitopes bound by the MAb PCG-4, a series of overlapping deletion clones were …
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CHARACTERIZATION OF CD4+ T CELL-INDUCING EPITOPES OF ISLETSPECIFIC GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT-RELATED PROTEIN (IGRP) THAT PREVENT AUTOIMMUNITY
… which contain MHC class Il-specific CD4+ T cell epitopes. Amino acid residues critical for the activity of P3 and P7 were determined by deletion mapping and alanine substitutions. Binding studies indicate that the affinity of P3 and P7 peptides for I-Ag7 correlates with their ability to prevent …
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Characterization of the alfalfa mosaic virus as expression, presentation, delivery and screening system for potential epitopes derived from the respiratory syncytial virus fusion protein
… was then used to screen for B- and T-cell epitopes. The data obtained was used to establish AlMV as a screening tool and evaluate its performance in different applications. This is the first study in which a plant virus has been used to identify potential B and T-helper cell epitopes for …
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Assessing TMV as an immunogenic particle : the expression of HIV-1 subtype C V3 loop neutralizing antibody epitopes on the surface of TMV virions
… to express recognized HIV neutralizing antibody epitopes. These epitopes were expressed on the surface of the TMV coat protein, which served as an ideal means of antigen display. This model antigen display system was capable of assembling into multivalent, highly repetitive structures thereby …
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