Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Epithelialization"”.
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Epidermis and Re-epithelialization in <i>Schmidtea mediterranea</i>
Epidermal layer is crucial for organism’s survival as its ability to close the wound is essential for tissue recovery. Planarian epidermis enables animal recovery and survival after virtually any body part amputation. Nevertheless, neither the epidermis nor the mechanisms endowing such a remarkable …
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Topical Antimicrobial and Bandaging Effects on Equine Distal Limb Wound Healing
… of healing parameter, rates of contraction and epithelialization were compared among groups using pair-wise analysis of least square means. The healing parameters and mean days to healing did not statistically differ between groups. Analysis of percent wound contraction and rate of …
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The Novel Role of Dnmbp In Kidney Development
… which requires transplant. During nephron epithelialization, the formation of stable cadherin-mediated adhesion junctions is essential for maintaining cell-cell contacts. To understand the cell behaviors underlying abnormalities in renal morphology and cyst formation and to facilitate the …
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Serine Metabolism Leverages the Integrated Stress Response to Direct Stem Cell Fate During Tissue Regeneration
… HFSCs skew their fate towards epidermal re-epithelialization while concomitantly limiting hair growth. Combining temporal single-cell RNA sequencing, loss-of-function genetics, and pharmacological intervention, I show that serine deficiency augments an injury-activated integrated stress …
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Mechanisms and dynamics of size regulation and lumen formation in mouse double embryos
… the embryonic tissue undergoes a process of epithelialization to form a lumen that later will become the pro-amniotic cavity, an essential morphogenetic event that is delayed in double embryos compared to normal-sized embryos. Mechanistic studies demonstrate that pro-amniotic cavity formation …
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Plasmacytoid Dendritic Cells Sense Skin Injury and Promote Wound Healing Through Type I Interferons
… the inflammatory response and delayed re-epithelialization of skin wounds. Thus we uncover a novel role of pDCs in sensing skin injury via TLR mediated recognition of nucleic acids and demonstrate their involvement in the early inflammatory process and wound healing response through the …
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Cell mechanics-based modelling and in toto imaging describe a new mode of lumen formation in chicken neural tube
… as an emergent property of cell differentiation (epithelialization) in the context of various tissue geometries such as plates and p. The aim of this model is to recapitulate lumen formation dynamics and test if a cohesive underlying set of cell behaviours are sufficient to tie primary and …
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The Columnar Lined Esophagus: aspects on the assessment of dysplasia and on the relationship with the esophageal submucosal glands
… counterparts of skin adnexa as a source of re-epithelialization, and conclude that in esophagus both neosquamous islands and columnar metaplasia originate in the submucosal gland unit.
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Gene therapy in a new model of delayed wound healing
… of fibroblasts or keratinocytes enhanced re-epithelialization in this new model of delayed wound healing. In study three, the beneficial effect of transplanting keratinocytes seen in study two was enhanced by transfecting keratinocytes with a plasmid coding for IGF-1. Results showed a …
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Collective migration of epithelial sheets
… barriers of the intestinal mucosae, as well re-epithelialization in the healing of wounds. Yet, considering their ubiquity and relevance, the basic origin of the collective motion of sheets has eluded a clear and quantitative interpretation in physical terms, prohibited by the lack of …
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Keratin Biomaterial Treatments For Burn Injury And Mechanisms Of Tissue Survival
… thermal stress model. The MKH showed a faster re-epithelialization rate and wound closure compared to other treatments. Finally, to investigate the potential clinical relevance to actual burn treatment, a delayed treatment thermal burn study was performed. These results showed that MKH was able to …
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Decellularized Cartilage for Airway Repair
… results demonstrated airway expansion, graft re-epithelialization, neocartilage formation, and integration with adjacent native laryngotracheal cartilage at 3 months. Notably, MEND implants performed better in all outcomes than autologous costal cartilage, the standard of care. No instances of …
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Novel hydrogels for keratoprosthesis
… in other core and skirt prostheses. However, epithelialization of this kind of solid, rigid optic material is clearly impossible. The approach to the development of a hydrogeJ for potential KPro use adopted in this work is to develop soft core material to mimic the properties of the natural …
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Preserved extracellular matrix in non-enzymatically detached cultured keratinocyte sheets bolsters the healing effects on grafted burn wounds
… wound healing was evidenced with a greater epithelialization rate and well defined dermal-epidermal junction with continuous and better-defined lamina densa and significantly higher numbers of hemi-desmosomes. Additionally, the wounds were more mature with T-KS treatment which was evidenced …
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The role of retinoids in the regeneration of the axolotl spinal cord
… suggested that the meninges could drive re-epithelialization of the reactive ependymal cells. Experiments to characterize this interaction show an unusual proliferation pattern: Proliferating Cell Nuclear Antigen (PCNA) labeling is present in intact and regenerating cord ependymal cells. …
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A Nuclear Mechanoresponse to Morphogenesis Drives Acquisition of Neuroectoderm Lineage Competence During Pluripotent Cell Differentiation
… the embryo undergo an apical constriction and epithelialization morphogenesis in parallel with a cell state transition to prepare for multilineage differentiation. I therefore hypothesized that pluripotency and subsequent cell fate specification involves nuclear mechanosensitivity to …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
… whereas A-P polarity, boundary formation, epithelialization or the later differentiation of somites appears to be affected. Such mutants have not been isolated so far in zebrafish, mice or chicken. Therefore, medaka class II somite mutants seem to be a novel group of mutants that opens new …
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Monitoring Tissue Function Dynamics in vitro with Bioelectronics: Towards Understanding Barrett’s Oesophagus Pathogenesis
… of the local keratinocytes results in re-epithelialization of the wound site by the BE progenitor cell type. Early-stage pathogenesis, characterised by tissue function dysregulation and epithelial erosion prior to ulceration, is considered a potential point of prophylactic application. …
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Characterisation of Cutaneous Wound Healing Process in Naked Mole Rats
… closure in NMR skin was achieved primarily by reepithelialization and granulation tissue formation, with only ~26% wound contraction, making them an excellent model to study human cutaneous wound healing. Similar to mice and human skin, changes in wound epithelial tongue included progressive …