Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 85 for “"Epithelial to mesenchymal transition (EMT)"”.
-
The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… the leading cause of cancer-related deaths due to conventional therapy resistance and metastatic disease, therefore understanding the mechanisms governing these biological functions is vital for improving patient survival. Approximately 30% of patients with the adenocarcinoma histologic subset …
-
Single-Cell Lineage Tracing Of Cancer Metastasis
… of cancer metastasis remain poorly understood, in part due to a lack of tools for probing their emergence at high resolution. Here we present macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder with highly efficient single-cell capture of both transcriptional and phylogenetic …
-
An examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumors
This thesis examines the connection between epithelial to mesenchymal transition (EMT) and cancer stem cells (CSC) in solid tumors. Epithelial to mesenchymal transition describes the conversion of cancer cells from an adherent, differentiated, and polar phenotype (epithelial) to a motile, plastic, …
-
Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
… artery development and are important mediators of myocardial pathogenesis. These cells form when a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and migrates into the myocardium. The pathways and mechanisms regulating epicardial derived cell (EPDC) …
-
Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
… relapse following surgery. Molecular and histological subtyping of CC has identified a poor-prognostic group of patients characterised by high levels of epithelial-to-mesenchymal transition (EMT) signalling and an abundance of stroma (particularly fibroblasts) in their tumour …
-
SOMATIC MUTATIONS AT FRAGILE ENHANCERS OF LINEAGE- IDENTITY EPITHELIAL GENES IN BREAST CANCER.
… Our lab identified paused RNA polymerase II and topoisomerase2B as key contributors to DSB formation at specific promoters, and further demonstrated that errors in end-joining during DSB repair lead to chromosome translocations observed in breast cancer patients. We hypothesized that specific …
-
Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer
… model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are hierarchical and only a rare subpopulation of cells, so-called “cancer stem cells” (CSCs), possess the unique biological properties …
-
Relationship between Processing Body Formation, Epithelial-to-Mesenchymal Transition, and Invasion in Lung Adenocarcinoma
… deaths in the United States, largely due to its ability to metastasize. Epithelial-to-mesenchymal transition (EMT) is a process that enhances the ability of cells to lose their cell-cell contacts, invade, and enter the blood stream which are essential during metastasis. Many …
-
Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt
… death in the United States due in part to the affinity of tumors to metastasize. Understanding the process which contributes to metastasis provides promise for the discovery of novel therapeutic targets. Epithelial-to-mesenchymal transition (EMT) is a proposed model for the initiation of …
-
The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… (S1P) is a bioactive lipid that has been shown to regulate hallmark cancer characteristics, one of which is Epithelial to Mesenchymal Transition (EMT). EMT is the mechanism by which an epithelial cell gains the motility to migrate throughout the body by shifting from a stationary epithelial …
-
Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… a highly metastatic breast cancer subtype. The epithelial-to-mesenchymal transition (EMT) of cancer cells is a key feature of the metastatic cascade and is not a binary process but often generates malignant cells with both epithelial (E) and mesenchymal (M) traits known as hybrid EM cells. …
-
The Effects of Atypical Protein Kinase C on TGFβ Signalling
The transforming growth factor beta (TGFβ) signalling pathway is an essential regulator of many cellular processes including epithelial growth control, epithelial to mesenchymal transition (EMT), apoptosis, and the establishment of developmental fate. Alterations in TGFβ signalling patterns are …
-
Maintenance of fetal membrane integrity by cyclic cellular transitions during gestation and parturition
… term is deemed ‘catastrophic’ and contributes to infection, preterm birth, and neonatal death. During gestation, membranes repair and remodel through a balanced collagenolytic process of the matrix. Individual sites of membrane remodeling have been identified and termed ‘microfractures.’ …
-
Molecular Drivers of Bladder Cancer Motility
… measured by the degree of tumor cell invasion into the bladder wall and dissemination to distant sites. The study of BC cell motility will both enable development of anti-invasion therapeutics to limit progression of early-stage disease and improve our understanding of the metastatic process …
-
Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
… induced by cigarette smoke. Pathology is linked to a series of inflammatory and fibrotic events in the small airways and lung parenchyma; including fibrosis, emphysema and mucus plugging. This work focuses on the inflammatory and fibrotic aspects of COPD pathology. Processes of fibrotic …
-
Defining and Targeting Epigenetic Rewiring During Tumor Progression
… critical for regulation of gene expression and to facilitate appropriate responses to environmental cues. However, it is increasingly appreciated that epigenetic dysregulation directly promotes therapeutic resistance and tumor progression. While genetic alterations have been shown to promote …
-
Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
… multiple isoforms that can be categorized into two main isoforms, TAp63 and ΔNp63, which are expressed in different cellular compartments and have distinct functions in many biological processes. While the Flores laboratory identified TAp63 as a tumor and metastasis suppressor, the precise …
-
Effects of TGF-β Inhibitor on Chemoresistance in Ovarian Cancer Models
… is the most fatal gynecological cancer, due to the aggressive, heterogeneous nature of the tumours. Despite an initially favourable treatment response, patients with HGSC often develop resistance to the first-line platinum-based chemotherapies. In addition, the few currently available second …
-
Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
… mortality in the United States and worldwide. Epithelial-to-mesenchymal transition (EMT) is a model for metastasis that results in loss of specialized epithelial cell contacts and acquisition of mesenchymal invasive capacity. Zinc finger E-box-binding homeobox 1 (ZEB1) recognizes and binds to …
Page 1 of 5