Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Epithelial homeostasis"”.
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… typically cause chronic infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role of two common viral targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the key components of epithelial …
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Understanding and Targeting Clearance of Persistent HPV Infections
… the great diversity of HPV types and tropism to epithelial sites (with associated diseases ranging from mild skin lesions to cancer), they share general genome organization and life strategy for long term infection after initial disease regression. Persistent infected cells form a viral …
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Krupple-Like Factor 4 Regulation in Intestinal Epithelial Differentiation, Proliferation and Polarity
… development, as well as the maintenance of epithelial homeostasis in the intestine. KLF4 is predominantly expressed in the epithelial cells that are fully differentiated in normal intestine. In colorectal cancer, KLF4 was identified as a tumor suppressor; it is also a stem cell factor that …
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Cigarette Smoke Exposure in Drosophila Reveals Wnt-Mediated Remodeling of Airway Structure and Systemic Physiology
… airflow limitation, chronic inflammation, epithelial injury, and impaired tissue repair, with cigarette smoke as its primary etiological factor. Increasing evidence implicates dysregulation of the Wnt signaling pathway in COPD pathogenesis, yet the distinct roles of canonical and …
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Molecular Mechanisms of Airway Epithelial Progenitor Cell Maintenance and Repair.
… airways are lined with a continuous layer of epithelial cells. Epithelial cells in the distal most part of the lung, the alveolar space, are specialized to facilitate gas exchange. Proximal to the alveoli is the airway epithelium, which provides an essential barrier and is the first line of …
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Development and Maintenance of the Thymic Epithelial Microenvironment
… self-tolerant T-cell population. Thymic epithelial cells play an essential role in the development of a naïve, self-tolerant T-cell population. Paradoxically thymus undergoes acute age-related involution, which in turn causes loss of functional T-cell populations. Involution reduces the …
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Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes
… E-cadherin serves as molecular Velcro in epithelial cells to maintain epithelial homeostasis. Despite passively bearing mechanical stress at cell-cell junctions, E-cadherin has been shown to actively respond to force to reinforce junction stability. However, classical E-cadherin …
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Modeling colorectal cancer initiation using human iPSC-derived intestinal organoids
… are known to contribute to neoplastic growth in epithelial tissue. However, Investigating the early molecular events associated with CRC continues to be an important topic of study. We generated inducible oncogenic mesenchyme-free hiPSC-derived HIOs to study the early molecular events associated …
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Identifying novel roles for basement membrane-associated proteins in the adult Drosophila intestinal epithelium
… the basal side of all epithelia, and to which epithelial cells adhere via various receptors. Despite their ubiquity, basement membranes are understudied and there remains much to understand regarding how their components and receptors impact epithelia. Using the adult *Drosophila* midgut as a …
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The gut microbiome: A key regulator of mucosal tolerance, barrier function, and vaccine response
… critical role of microbiota in both maintaining epithelial homeostasis and shaping immune responses in the context of immunization. Additionally, this work delves into the complex relationship between microbiota composition and mucosal tolerance, emphasizing how these interactions shape the …