Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"Epithelial cancer"”.
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Gonadotrophins and cytokines in ovarian epithelial cancer / John Alexander Latimer
This thesis compares the rates of mitotic activity of the ovarian surface epithelium (OSE) and the peritoneal mesothelium (PM) and the effects of ovarian hyperstimulation using a rodent model. The study provides also information about cytokine expression and production in benign and malignant …
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Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
Liver fibrosis and cancer metastasis remain significant health problems, with a mortality rate of nine million each year worldwide. Effective therapies for these problems are very limited due to lack of a clear understanding of the underlying mechanisms. Epithelial-mesenchymal-transition (EMT) is a …
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Cyclic AMP modulation and its effects on chemo-resistant colon cancer cell proliferation and survival
… of the major problems associated with colorectal cancer is resistance to cytotoxic chemotherapeutic agents. New strategies are therefore required to inhibit colon cancer proliferation and survival. Here I use modulators of cAMP pathways, including inhibitors of phosphodiesterase 4 (PDE4) enzymes, …
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Disrupting Tymp-Mediated Pathways to Block Lymph Node Metastasis in Ovarian Cancer
<p>Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. In epithelial ovarian cancer, the mechanisms driving lymph node (LN) metastasis are poorly understood, and it …
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CROSSTALK BETWEEN TUMOUR VASCULATURE AND OVARIAN CANCER STEM CELLS: THE ROLE OF L1CAM.
Ovarian cancer is the most lethal gynaecologic tumour, mainly due to relapse and chemoresistance, two events fuelled by ovarian cancer stem cells (OCSC). The tumour microenvironment (TME) is thought to act as a niche for OCSC, preserving stem cells properties and sustaining tumour recurrence. The …
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ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition
Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The Epithelial-Mesenchymal Transition (EMT) provides a model by which tightly …
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The Role of the Methyl DNA Binding Domain Protein 2 (MBD2) in Breast Cancer
… role of Methyl-Binding Domain Proteins (MBDs) in cancer, where repatterning of CpG methylation is common. In this dissertation I summarize and discuss observations made in the Ginder Lab linking MCBPs to the progression of neoplastic disease. It is clear from our work that the Methyl Binding …
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Uncovering The Zeb1 Interactome to Identify Novel Regulators of Metastatic Non-Small Cell Lung Cancer
<p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the United States, due in part to the robust affinity of lung cancer cells to metastasize. Understanding the processes that contribute to metastasis provides promise for the discovery of novel therapeutic targets. …
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Identification of mechanisms of gemcitabine resistance using a whole genome shRNA screen in a novel in vitro coculture model of pancreatic cancer.
… remains one of the most difficult to treat major cancers, with a 5-year survival of less than 5%, and little to no improvement in prognosis over the previous fifty years. The complexity and heterogeneity of the pancreatic tumour and its highly desmoplastic stromal microenvironment present major …
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Metastatic cell responses to anticancer therapy: The possible role of cancer stem cells
Metastasis is a multistep process, by which cancer cells dissociate from the initial site and travel to form new secondary tumours at distant sites. This process has been reported to require epithelial-mesenchymal transition (EMT), by which the epithelial cancer cells convert to a mesenchymal form, …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
<p>Breast cancer is classified based on the expression of three markers estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor (HER2). Breast cancers that express these targets are classified as hormone receptor (HR) positive breast cancer and the tumors that lack …
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Investigating the effects of EZH2 inhibitors on targeting epigenetic changes in head and neck squamous cell carcinoma
… E6 and E7 are the main causative agents for cancer progression in HPV positive HNSCC, due to their interactions with tumour suppressor proteins P53 and Rb and the HPV oncogene’s ability to inactivate them. Similarly, in HPV negative HNSCC mutations in the p53 and Rb tumour suppressors are …
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ASSESSMENT OF VARIABLE-DOSE SCHEDULING EFFECTS ON THE KINETICS AND HOMING OF ANTIGEN-SPECIFIC T CELLS IN CANCER VIA OPTICAL IMAGING
Ovarian Epithelial cancer is the most prevalent form of ovarian cancer overall. It is the leading cause of gynecologic cancer mortality, partly due to its lack of distinctive symptoms. The mainstay for treatment for metastatic ovarian cancer has largely been chemotherapeutics, but recently …
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Optical reflectance spectroscopy for cancer diagnosis : analysis and modeling
… is motivated by the detection of oral cancer, but some of the methods developed can be generalized to epithelial cancers of other sites. Two main topics are covered in this dissertation: Analysis and Modeling. For analysis, the focus is on developing algorithms to make diagnostic …
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Novel Cellular Targets of Aspirin in Chemoprevention studies on P53, G6PD and c-MYC
… pathways by which aspirin exerts its anticancer effects in epithelial cancer cell lines. We investigated the effect of aspirin on p53, glucose 6-phosphate dehydrogenase (G6PD), and c-Myc, all of which are known to play a major role in cancer development. p53 is a tumor suppressor protein, …
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PATHOLOGY OF THE UROGENITAL TRACT IN DOMESTIC ANIMALS
… is considered one of the main players in cancer development and progression and may influence the behaviour of cancer cells. Periostin (POSTN) is an extracellular matrix protein, and its main functions are induction of fibrillogenesis, fibroblastic cell proliferation and migration, …
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INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… processes, such as neo-angiogenesis and cancer spreading. Integrins are composed by an extracellular domain, a single transmembrane region and a short cytoplasmic tail. In particular, the cytoplasmic domain is crucial for the regulation of integrin activity and function. It controls the …