Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Epithelial barriers"”.
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Development of nanoparticles for oral delivery of insulin
… as well as allow targeted transport across the epithelial lining. An efficient NP based oral insulin delivery solution that can enable targeted transport of insulin across the GI tract must have (1) high insulin loading, (2) sub-100 nm size, (3) ability to release insulin before opsonization by …
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Role of matriptase in the regulation of epithelial barrier permeability studied using MDCK cells
… the!integrity!of!epithelial!barriers.!However,!the!molecular!mechanisms!underlying! the!role!of!matriptase!are!unknown.! To! study! these!mechanisms,! two!variants!of!MadinNDarby!canine!kidney!(MDCK)! cells!were! used,! together!with! the! “calciumNswitch”!model! …
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TLR4 expression on equine B lymphocytes: a clue to LPS sensitivity?
… by Toll-like receptor 4 (TLR4). In cases where epithelial barriers are compromised or breached LPS has the potential to enter circulation and cause the inflammatory symptoms seen with endotoxemia. The objective of this study was to determine TLR4 presence and functionality on equine B cells. …
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Lipid Signaling Under Microgravity Conditions
… tissues is compromised during Space missions. Epithelial barriers, whose primary role is the host defense, are among the first tissues to be affected by Space stressors. Intesti-nal epithelial cells (IECs), which form the intestinal lining, respond to environmental insults – including pathogens …
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CNS Remyelination and the Gut Microbiota
… microbes communicate with host cells at epithelial barriers, stimulate neural and endocrine axes and directly produce a plethora of long-range signalling molecules. Critically, the development and maintenance of the immune system depend on signals from the microbiota, and we know that a …
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Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications
… remains a significant challenge because of the barriers presented by the gastrointestinal tract. In particular, transport across the intestinal epithelium limits efficient oral delivery of NPs. The neonatal Fc receptor (FcRn) mediates IgG antibody transport across epithelial barriers. It was …
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Cellular and Molecular Mechanisms of Immunoregulation In Vivo
… response to maintain homeostasis including: epithelial barriers, innate responses, and adaptive responses. Programed death-1 (PD-1) is an inhibitory co-stimulatory molecule originally described to promote exhaustion or inhibit the function of effector T cells. PD-1 deficiency is associated …
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Developing bioelectronic sensors for 3D in vitro models at the air liquid interface: Innovative technology for biomedical and respiratory research.
… are characterized by aberrant immune and epithelial barrier function, leading to respiratory inflammation and tissue damage. Despite substantial progress in identifying therapeutic targets and drug candidates, the efficacy of novel treatments in clinical trials remains low. One of the …